Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF‐β1/Smad signaling

Meng, Songyan; Yang, Fan; Wang, Yueqiu; Qin, Ying; Xian, Huimin; Che, Hui; Wang, Lihong

doi:10.1002/cbin.11079

Cited by 32 publications

(30 citation statements)

References 40 publications

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“…It has nephroprotective effects in T2DM and can reduce blood glucose levels [982]. Currently, Meng et al [983] showed that silymarin ameliorates diabetic cardiomyopathy through the inhibition of TGF-β1/Smad signaling, suggesting that silymarin could have a potential role in diabetic cardiomyopathy treatment.…”

Section: Phytochemicals With Antidiabetic Potentialmentioning

confidence: 99%

Antidiabetic Potential of Medicinal Plants and Their Active Components

et al. 2019

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Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.

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Section: Phytochemicals With Antidiabetic Potentialmentioning

confidence: 99%

Antidiabetic Potential of Medicinal Plants and Their Active Components

et al. 2019

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“…Thus, this study points towards the potential of silymarin in improving diabetic cardiomyopathy by inhibiting TGF-β1/SMAD signaling. Silymarin can be a potential new candidate for the treatment of diabetic cardiomyopathy ( Meng et al, 2019 ).…”

Section: Role Of Tgf-β Signaling In Diabetesmentioning

confidence: 99%

Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights

et al. 2020

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Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechanisms of diabetes still need to be explored. This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-b signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. Dysregulated autophagy in pancreatic b cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. Consequently, several therapeutic agents such as adiponectin, ezetimibe, GABA tea, geniposide, liraglutide, guava extract, and vitamin D were shown to inhibit diabetes and its complications through modulation of the autophagy pathway. Another pathway, TGF-b signaling pathway, appears to play a part in the progression of diabetes, insulin resistance, and autoimmunity in both type 1 and 2 diabetes and complications in diabetes. Subsequently, drugs that target TGF-b signaling, especially naturally derived ones such as resveratrol, puerarin, curcumin, hesperidin, and silymarin, as well as Propolis, Lycopus lucidus, and Momordica charantia extracts, may become promising alternatives to current drugs in diabetes treatment. This review provides keen insights into novel therapeutic strategies for the medical care of diabetes.

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“…T2DM-induced accumulation of extracellular matrix (ECM) proteins in the heart, also known as myocardial fibrosis, is the most marked histopathological change associated with DCM [8,14,15,[80][81][82][83][84]. Myocardial fibrosis leads to structural and functional changes in the heart through collagen deposition, interstitial fibrosis, and perivascular fibrosis [14].…”

Section: Myocardial Fibrosismentioning

confidence: 99%

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Seo

Jang

et al. 2019

IJMS

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Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

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Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF‐β1/Smad signaling

Cited by 32 publications

References 40 publications

Antidiabetic Potential of Medicinal Plants and Their Active Components

Antidiabetic Potential of Medicinal Plants and Their Active Components

Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

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