Antidiabetic Potential of Medicinal Plants and Their Active Components

Salehi, Bahare; Ata, Athar; N, Anil Kumar; Sharopov, Farukh; Ramírez‐Alarcón, Karina; Ruíz-Ortega, Ana M.; Ayatollahi, Seyed Abdulmajid; Fokou, Patrick Valère Tsouh; Kobarfard, Farzad; Zakaria, Zainul Amiruddin; Iriti, Marcello; Taheri, Yasaman; Martorell, Miquel; Sureda, Antoni; Setzer, William N.; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Capasso, Raffaele; Ostrander, Elise Adrian; Atta-ur-Rahman, _; Choudhary, Muhammad Iqbal; Cho, William C.; Sharifi‐Rad, Javad

doi:10.3390/biom9100551

Cited by 394 publications

(277 citation statements)

References 814 publications

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“…Simpler and painless routes for insulin administration are still in demand to manage diabetes as conventional drug delivery systems still have numerous drawbacks, including improper and/or ineffective dosage, low potency, limited specificity for the target, which may result in adverse side effects in other organs/tissues. The use of natural products could be the potential to encounter the limitations of DM treatment [2,14,15]. To overcome the pharmacokinetic limitations of drugs, the novel drug delivery system has considered as an attractive option to deliver the drugs for treating several diseases and disorders [2,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

et al. 2020

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The antidiabetic, hypoglycemic and oral glucose tolerance test (OGTT) activities of zinc oxide nanoparticles (ZnONPs) were assessed in mice. ZnONPs were prepared by reacting Zn(NO3)2.6H2O and NaOH solution at 70°C with continuous stirring and then characterized by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) techniques. Diabetes was induced by the intraperitoneal injection of streptozotocin (STZ) in mice, and then the blood glucose levels were determined by the glucose oxidase method. The experimental results revealed that ZnONPs suggestively (p<0.001) declined the blood glucose levels (39.79%), while these reductions were 38.78% for the cotreatment of ZnONPs and insulin, and 48.60% for insulin, respectively. In the hypoglycemic study, ZnONPs (8 and 14 mg/kg b.w) reduced approximately 25.13 and 29.15% of blood glucose levels, respectively. A similar reduction was found in the OGTT test, which is also a dose- and time-dependent manner. Overall, ZnONPs possess a potential antidiabetic activity, which could be validated by further mechanistic studies.

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Section: Introductionmentioning

confidence: 99%

Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

et al. 2020

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“…In recent times, the use of conventional drugs for the treatment and management of diabetes has raised a lot concern from the general public because of their constitutive side effects, thus promoting the exploration of medicinal plants as alternative therapies [370,371]. A number of medicinal plants used in the management or treatment of diabetes in folk medicine have been proven to possess a large amount of bioactive components which elicit antihyperglycemic or antidiabetic activity [371,372]. In spite of all these great attributes and potentials ascribed to medicinal 11 Oxidative Medicine and Cellular Longevity Table 1: Plant extracts that elicited their antidiabetic potential using both alloxan and streptozotocin-induced diabetic rats.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Oxidative Medicine and Cellular Longevity [371]. It was also found that the administration of gliberclamide alone to 72 T2DM patients (49 men and 23 women) with elevated FBG levels did not ameliorate the blood glucose levels, whereas those administered 80% Aloe vera juice together with gliberclamide recorded a decline in the level of FBG in less than two weeks administration with no harm done in both the liver and kidney [371,380]. In addition, Aloe QDM complex or placebo was orally administered during a randomized control trial (8 weeks) to one hundred and thirty-six (136) participants who were randomly assigned to the sixty-eight (68) participants from each group.…”

Section: Zaleya Decandramentioning

confidence: 99%

“…The antidiabetic potentials of cinnamon are highly appreciated in Ayurvedic and Chinese medicine [382] with an increase in the number of discoveries about its insulin boosting potentials [383,384]. However, contradictory results have emerged from clinical trials using cinnamon as supplementation [371,385,386]. From the five clinical studies reviewed by Kirkham et al [385], one study involves a randomized, placebo-controlled clinical trial that investigated the effect of cinnamon on blood glucose levels using a total 311 participants (eight studies) which were divided into five type 2 diabetic and three nondiabetic groups, respectively.…”

Section: Zaleya Decandramentioning

confidence: 99%

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Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

Unuofin

Lebelo

2020

Oxidative Medicine and Cellular Longevity

152

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Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory responses and beta cell dysfunction. This ailment affects as many as 451 million people worldwide, and it is also one of the leading causes of death. In spite of the immense advances made in the development of orthodox antidiabetic drugs, these drugs are often considered not successful for the management and treatment of T2DM due to the myriad side effects associated with them. Thus, the exploration of medicinal herbs and natural products as therapeutic sources for the treatment of T2DM is promoted because they have little or no side effects. Bioactive molecules isolated from natural sources have been proven to lower blood glucose levels via regulating one or more of the following mechanisms: improvement of beta cell function, insulin resistance, glucose (re)absorption, and glucagon-like peptide-1 homeostasis. In recent times, the mechanisms of action of different bioactive molecules with antidiabetic properties and phytochemistry are gaining a lot of attention in the area of drug discovery. This review article presents an update of the findings from clinical research into medicinal plant therapy for T2DM.

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“…Mice in the APS and Ex + APS groups were fed oral AP (200 mg/kg weight) with a feeding needle one hour before the start of exhaustive exercise to allow enough time for potential AP effects to occur before exercise began (Ex + APS) or the pseudo start time (APS). We selected the dose based on previously published studies [12,13]. The AP used in this study was kindly provided by Amino Up Chemical Co., Ltd. (Sapporo, Japan).…”

Section: Experimental Animals and Sample Processingmentioning

confidence: 99%

Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle

2019

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The purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after exhaustive exercise. Exhaustive exercise also decreased liver glutathione (GSH). These results suggest that the exhaustive exercise used in this study induced tissue damage and oxidative stress. Contrary to our expectations, AP supplementation increased plasma AST and alanine aminotransferase activities, liver levels of TBARS, and protein carbonyls. Furthermore, AP supplementation decreased glutathione and glutathione peroxidase activity in the liver. On the other hand, AP supplementation decreased TBARS levels in skeletal muscle. These results suggest that oral high-dose AP administration decreased oxidative stress in skeletal muscle but induced oxidative stress in the liver and increased hepatotoxicity.

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Antidiabetic Potential of Medicinal Plants and Their Active Components

Cited by 394 publications

References 814 publications

Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle

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