Silylation with the Generation of a Fixed Charge for the Analysis of Alcohols by MALDI and SALDI Mass Spectrometry

An asymmetric Salamo-based Zn complex supported on Fe3O4 MNPs: a novel heterogeneous nanocatalyst for the silyl protection and deprotection of alcohols under mild conditions

“…Besides, R 3 SiCl, MeSiN ¼ C(Me)OSiMe, Me 3 SiCl, or Me 3 SiOTf in the presence of base are the reagents applied in the traditional and conventional processes. 12,[21][22][23][24][25][26][27][28][29] Moreover, hexamethyldisilazane (HMDS) is a stable, commercially available and inexpensive reagent that can be used for the protection of hydroxy bearing compounds to trimethylsilyl ethers. [30][31][32] Its handling does not require special precautions, and the workup is not timeconsuming because the by-product of the reaction is ammonia, which is easily removed from the reaction medium.…”

Molecular insights into symbiosis—mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation

“…However, because of poor ion yields, the analysis of neutral sterols like cholesterol or phytosterols is challenging with these techniques. Therefore, different derivatisation techniques have been introduced, based on Girards hydrazine reagents like Girard T reagent used to target keto groups [ 20 – 22 ], silylation [ 23 ], or pyridine sulfur trioxide [ 22 ], to significantly increase ion yields. Upon use of on-tissue derivatisation, these techniques have also been translated to the field of mass spectrometry imaging (MSI).…”

Recent advances in catalytic silylation of hydroxyl‐bearing compounds: A green technique for protection of alcohols using Si–O bond formations

“…[39] Besides, R 3 SiCl, MeSiN=C (Me)OSiMe, Me 3 SiCl, or Me 3 SiOTf in the presence of base can be considered as reagents applied in the traditional and conventional processes. [40][41][42][43][44][45][46][47][48][49] It is worth mentioning that there are some specific demerits afflicting these methods, that is, lack of reactivity, long reaction times, and difficult-to-remove by-products and co-bases during the reaction. Generating only the ammonia gas as the by-product, hexamethyldisilazane (HMDS) that is cheap, noncorrosive, and easy to handle can be used to form trimethylsilyl ether.…”