Silybum marianum (L.) Gaertn: the Source of Silymarin

Corchete, Purificación

doi:10.1007/978-3-540-74603-4_6

Cited by 39 publications

(33 citation statements)

References 110 publications

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“…The most common compound in milk thistle is silymarin, which is an isomeric mixture of flavonolignans (silybin, silychristin, and silydanin) present in S. marianum (L). Silymarin acts as a strong anti-hepatotoxic, which has been used for chronic inflammatory liver disease and liver cirrhosis 15 . Milk thistle is hepatoprotectants for Cancer Patients.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Silybum marianum (L).

Padma¹,

Ganesan²,

Jayaseelan³

et al. 2019

J. Drug Delivery Ther.

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Objective: To investigate the phytochemicals and GC-MS analysis of ethanol extracts of Silybum marianum. Methods: The air-dried leaves were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, ethanol to obtain an ethanolic extract. Then, each of the extracts was further subjected to gas chromatography-mass spectrometry. Results: Qualitative determination of the different biologically active compounds from crude extracts of Silybum marianum using gas chromatography-mass spectrometry revealed different types of high and low molecular weight chemical entities with varying amounts present in each of the extracts. These chemical compounds are considered biologically and pharmacologically important. Conclusions:The study established the chemical composition and anticancer activity of the plant.

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Section: Introductionmentioning

confidence: 99%

Phytochemical screening and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Silybum marianum (L).

Padma¹,

Ganesan²,

Jayaseelan³

et al. 2019

J. Drug Delivery Ther.

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“…The most common compound in milk thistle is silymarin, which is an isomeric mixture of flavonolignans (silybin, silychristin, and silydanin). Silymarin acts as a strong anti-hepatotoxic, which has been used for chronic inflammatory liver disease and liver cirrhosis [2].…”

Section: Introductionmentioning

confidence: 99%

In vitro Production of Silymarin from Silybum marianum L.

Al-Hawamdeh¹,

Shibli

Al-Qudah³

2014

Med Aromat Plants

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“…Silybum marianum (milk thistle) seeds have been used as medicine for over 2000 years. Theophrastus (4 th century BCE) described it under the name "Pternix" and Dioscorides used the name "Sillybom" in Materia Medica [1 th century CE] and prescribed the use of its tea for snake bites (Corchete, 2008). Silymarin is the main active ingredient of the milk thistle seeds.…”

Section: Introductionmentioning

confidence: 99%

“…The inflorescences are solitary large heads located at the apex of the stem, or at the primary and secondary branches. The florets are hermaphrodite, tubular in shape, with a red-purple or white corolla (Gresta et al, 2006;Corchete, 2008;Vaknin et al, 2008). Milk thistle is predominantly a self-pollinator (Hetz et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Breeding Objectives and Selection Criteria for Milk Thistle [<i>Silybum marianum</i> (L.) Gaertn.] Improvement

Alemardan

Karkanis

Salehi

2013

Not Bot Hort Agrobot Cluj

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Milk thistle [Silybum marianum (L.) Gaertn.] is an important medicinal-industrial plant. The medicinal compounds of milk thistle are derived from its seeds. The plant is commercially cultivated for the production of silymarin. Cultivation offers the opportunity to optimise achene yield and silymarin content. Furthermore, efforts should be made to develop new cultivars. The main objective of milk thistle breeding is to develop high yielding cultivars with elevated silymarin content. There are few developed cultivars of milk thistle (e.g. Argintiu, Budakalaszi, Szibilla, Khoreslo, Babak Castle, Mirel, Silma and Silyb). Different genotypes of milk thistle have variable amount of silymarin e.g. a 'Royston' genotype is rich in silymarin (6-10%). Further progress can be made by using the genetic diversity available in abundance in different genotypes. The main concern of the breeder should be to increase the yield and silymarin contents of the seeds. Asynchronous flowering and seed shedding are also major problems in milk thistle cultivation. At the time of harvest, the plants have flower heads at all stages of development resulting non-uniform maturation of seeds. Therefore, a breeding effort in milk thistle should be planned to obtain plants with simultaneous flowering and reduced crop losses. The developed cultivar Argintiu is characterised by simultaneous seed maturation in flower heads. The wild populations, as valuable gene pools, could be exploited for the improvement of milk thistle crop.

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Silybum marianum (L.) Gaertn: the Source of Silymarin

Cited by 39 publications

References 110 publications

Phytochemical screening and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Silybum marianum (L).

Phytochemical screening and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Silybum marianum (L).

In vitro Production of Silymarin from Silybum marianum L.

Breeding Objectives and Selection Criteria for Milk Thistle [<i>Silybum marianum</i> (L.) Gaertn.] Improvement

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