Silver-zinc oxide nanocomposite: From synthesis to antimicrobial and anticancer properties

Kouhi, Seyed Mousa Mousavi; Beyk-Khormizi, Abdollah; Amiri, Mohammad Sadegh; Mashreghi, Mohammad; Yazdi, Mohammad Ehsan Taghavizadeh

doi:10.1016/j.ceramint.2021.04.160

Cited by 84 publications

(24 citation statements)

References 66 publications

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“…45 The anti-proliferative effect has been noted as one of the anticancer mechanisms attributed to cell cycle and apoptosis induction in cancer cells. 46 We here showed that the CeO 2 -NPs significantly modulated the expressions of apoptotic genes in the cancerous A2780 cell line, as shown by RT-PCR. Among the key agents contributing to apoptosis regulation is Bcl-2, as well as other processes such as cytochrome C and caspase-9 activation.…”

Section: Discussionmentioning

confidence: 54%

Apoptotic Genes’ Expression in an Ovarian Cancer Cell Line (A2780) Exposed to Green Synthesized Cerium Oxide Nanoemulsion

Ashna

Es‐haghi

Soltani

2021

Int J Basic Sci Med

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Introduction: Cancer can be defined as an illness of reformed gene expression. There are numerous agents affecting gene expression and altering cellular activities. Nanotechnology has offered the possibility of modulating tumor suppressor genes’ expression, improving kinetics of gene-targeted therapeutics, and simplifying drug delivery to tumors and across bio-complexes.Methods: Gene expressions of caspase3, 8 and 9, Bax and Bcl2 were assessed after RNA extraction and cDNA synthesis by real-time polymerase chain reaction (PCR) in an ovarian cancerous cell line (A2780). Real-time PCR was employed to determine the change fold of apoptotic genes in the cells exposed to the biosynthesized CeO2-NPs (cerium oxide nanoparticles) at the dose of 0, 7, 9, and 11 μg/mL after 24 hours of incubation. Results: Our findings displayed a significant increase in the antioxidant genes’ expression in the A2870 cells. The results exhibited that the biosynthesized CeO2-NPs could enhance the Bax/Bcl2 ratio in a dose-dependent way. Also, the expression of caspase3, 8, and 9 up-regulated significantly under the dose of 11 μg/mL.Conclusion: Considering the effects of the bio-fabricated CeO2-NPs on the expression of apoptotic genes in ovarian cancerous cell lines, these nanoparticles (NPs) may be employed in pharmacology to develop new anti-cancer medications.

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Section: Discussionmentioning

confidence: 54%

Apoptotic Genes’ Expression in an Ovarian Cancer Cell Line (A2780) Exposed to Green Synthesized Cerium Oxide Nanoemulsion

Ashna

Es‐haghi

Soltani

2021

Int J Basic Sci Med

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“…The stability, electrostatic and dynamic behavior of nano and micron-sized particles are studied using DLS analysis. 51 The particle size distribution and zeta potential of charged colloids can be determined based on light scattering. Due to Brownian motion, the local density of suspended particles fluctuates temporarily in a colloid.…”

Section: Resultsmentioning

confidence: 99%

Highly efficient, bioactive, and bifunctional sorbent p–n–p visible light heterogeneous photocatalyst utilizing ultra-fine ZnS nanoparticles embedded in a polymeric nanocomposite

et al. 2022

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“…Because of more cellular absorption and withholding of plant-based silver-zinc oxide alloy nanoparticles, these NPs induce more toxic effects against HepG-2 cell line than normal cells like NIH-3T3 which was certainly time and quantity dependent. The nanometer size of particles showed the best toxic effect on human cervical cancer cells (HeLa), which can readily enter cells, generating reactive oxygen species resulting in cell mortality [ 99 ]. Justicia adhatoda derived silver/zinc oxide-based nanoparticles that positively charged silver, zinc metal ion produces more injuries as compared to negatively charged ion, because of ionic contact with cell membrane which is negatively charged.…”

Section: Plant-derived Ag/zno Nps: Usesmentioning

confidence: 99%

Plant-Based Bimetallic Silver-Zinc Oxide Nanoparticles: A Comprehensive Perspective of Synthesis, Biomedical Applications, and Future Trends

Ehsan

Waheed

Ullah

et al. 2022

BioMed Research International

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The universal emphasis on the study of green nanotechnology has led to biologically harmless uses of wide-ranged nanomaterials. Nanotechnology deals with the production of nanosized particles with regular morphology and properties. Various researches have been directed on nanomaterial synthesis by physical, chemical, and biological means. Understanding the safety of both environment and in vivo, a biogenic approach particularly plant-derived synthesis is the best strategy. Silver-zinc oxide nanoparticles are most effective. Moreover, these engineered nanomaterials via morphological modifications attain improved performance in antimicrobial, biomedical, environmental, and therapeutic applications. This article evaluates manufacturing strategies for silver-zinc oxide nanoparticles via plant-derived means along with highlighting their broad range of uses in bionanotechnology.

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Silver-zinc oxide nanocomposite: From synthesis to antimicrobial and anticancer properties

Cited by 84 publications

References 66 publications

Apoptotic Genes’ Expression in an Ovarian Cancer Cell Line (A2780) Exposed to Green Synthesized Cerium Oxide Nanoemulsion

Apoptotic Genes’ Expression in an Ovarian Cancer Cell Line (A2780) Exposed to Green Synthesized Cerium Oxide Nanoemulsion

Highly efficient, bioactive, and bifunctional sorbent p–n–p visible light heterogeneous photocatalyst utilizing ultra-fine ZnS nanoparticles embedded in a polymeric nanocomposite

Plant-Based Bimetallic Silver-Zinc Oxide Nanoparticles: A Comprehensive Perspective of Synthesis, Biomedical Applications, and Future Trends

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