Silver Oxide Based Nanoparticle Assisted Laser Desorption/Ionization Mass Spectrometry for the Detection of Low Molecular Weight Compounds

Abstract

A speci c property of silver oxide-based nanoparticles permits the ionization of an analyte, giving rise to various applications of a smart analytical methodology. e nanoparticles (d=6.7 nm) contained an Ag 2 O core. e detection of several model componds (a nucleobase and two hair growth promoters) via the use of silver oxide nanoparticles is described. Adducts were produced between the target molecules and the two silver stable isotopes (Ag 107 and Ag 109), resulting in the formation of speci c signals as well as a protonated signal. us, it was possible to easily determine whether the given signals were correlated with the target molecule or not.

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

“…For LDI experiments, silver nanoparticles in the methanolwater system containing citrates was mixed with 1 mM analyte citrate buffer solution and deposited on an indium tin oxide (ITO) conductive glass substrate. 40 Silver nanostructures for microbial analysis MALDI-MS with silver nanostructures was used for characterization of species of pathogenic bacteria, with silver nanoparticles used as affinity probes to capture whole microorganism cells. The peaks of p-aminothiophenol were found as clusters containing 1-3 silver ions/atoms and paminothiophenol molecules in contrast to the single peaks of the rhodamine 6G protonated adduct and cholesterol silver adduct.…”

“…44 The interactions of bacteria with nanostructures which are responsible for MALDI detection and identification of microbial compounds were also analyzed. 40,45,46 This problem may be partially solved with a surface-assisted laser desorption/ionization (SALDI) approach that was originally developed by Sunner et al 16 The SALDI desorption/ionization process is performed with the help of active surfaces and no 'traditional' organic matrix is used. 40,45,46 This problem may be partially solved with a surface-assisted laser desorption/ionization (SALDI) approach that was originally developed by Sunner et al 16 The SALDI desorption/ionization process is performed with the help of active surfaces and no 'traditional' organic matrix is used.…”

Nanoparticle-Assisted Laser Desorption/Ionization Mass Spectrometry (Nano-PALDI MS) with Py-Tag for the Analysis of Small Molecules

“…In previous reports, various analytes such as drugs, lipids, peptides, synthetic polymers and proteins could be ionized and imaged by Nano-PALDI MS. [1][2][3][4][5] e nanoparticles used in this study were synthesized by mixing aqueous solutions of 3d transition metal chlorides (MCl 2 ·nH 2 O) and 3-aminopropyltriethoxysilane in a single step, resulting in particles with a metal oxide core coated with a functionalized silicate sheet and are able to ionize analytes. e nano-PALDI method has problems associated with sensitivity although it is a suitable method for ionizing and detecting low molecular weight compounds.…”