Silver nanoprisms as plasmonic enhancers applied in the photodynamic inactivation of Staphylococcus aureus isolated from bubaline mastitis

Rodrigues, Cláudio Henrique; Araújo, Evanísia Assis Góes de; Almeida, Rômulo P.; Nascimento, Thiago Pajeú; Abbas, Ghulam; Nunes, Frederico; Lins, Emery C.; Nogueira, Mariane Cajubá de Britto Lira; Falcão, Juliana S. A.; Fontes, Adriana; Porto, Ana L.F.; Pereira, Goreti; Santos, Beate S.

doi:10.1016/j.pdpdt.2021.102315

Cited by 8 publications

(8 citation statements)

References 70 publications

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“…A similar behavior was observed by Rigotto-Caruso et al, 10 who reported a reduction of the ζ absolute value of AgNPs due to the presence of cationic phenothiazines. Likewise, Rodrigues et al 9 also observed a reduction in the ζ modulus when Ag nanoprisms were associated with the cationic dye methylene blue.…”

Section: Resultsmentioning

confidence: 84%

“…In this way, spectral changes may suggest that there was an interaction between ZnPs and AgNPs. 9 , 32–34 …”

Section: Resultsmentioning

confidence: 99%

“…2,3 In addition to the design of PSs with improved cellular interaction and photophysical properties, innovative approaches employing nanotechnology have also been explored to enhance PDI efficiency. [8][9][10][11] On this matter, silver nanoparticles (AgNPs) have been showing antimicrobial effect and ability to increase microbial photoinactivation when associated with PSs. 10,[12][13][14] Light can induce a collective oscillation of electrons of the conduction band of metallic NPs, known as the localized surface plasmon resonance (LSPR) effect.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Strategy Based on Zn(II) Porphyrins and Silver Nanoparticles to Photoinactivate Candida albicans

Raposo¹,

Souza²,

Santana³

et al. 2023

IJN

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Background Photodynamic inactivation (PDI) is an attractive alternative to treat Candida albicans infections, especially considering the spread of resistant strains. The combination of the photophysical advantages of Zn(II) porphyrins (ZnPs) and the plasmonic effect of silver nanoparticles (AgNPs) has the potential to further improve PDI. Here, we propose the novel association of polyvinylpyrrolidone (PVP) coated AgNPs with the cationic ZnPs Zn(II) meso -tetrakis( N -ethylpyridinium-2-yl)porphyrin or Zn(II) meso -tetrakis( N -n-hexylpyridinium-2-yl)porphyrin to photoinactivate C. albicans . Methods AgNPs stabilized with PVP were chosen to allow for (i) overlap between the NP extinction and absorption spectra of ZnPs and (ii) favor AgNPs-ZnPs interaction; prerequisites for exploring the plasmonic effect. Optical and zeta potential (ζ) characterizations were performed, and reactive oxygen species (ROS) generation was also evaluated. Yeasts were incubated with individual ZnPs or their respective AgNPs-ZnPs systems, at various ZnP concentrations and two proportions of AgNPs, then irradiated with a blue LED. Interactions between yeasts and the systems (ZnP alone or AgNPs-ZnPs) were evaluated by fluorescence microscopy. Results Subtle spectroscopic changes were observed for ZnPs after association with AgNPs, and the ζ analyses confirmed AgNPs-ZnPs interaction. PDI using ZnP-hexyl (0.8 µM) and ZnP-ethyl (5.0 µM) promoted a 3 and 2 log 10 reduction of yeasts, respectively. On the other hand, AgNPs-ZnP-hexyl (0.2 µM) and AgNPs-ZnP-ethyl (0.6 µM) systems led to complete fungal eradication under the same PDI parameters and lower porphyrin concentrations. Increased ROS levels and enhanced interaction of yeasts with AgNPs-ZnPs were observed, when compared with ZnPs alone. Conclusion We applied a facile synthesis of AgNPs which boosted ZnP efficiency. We hypothesize that the plasmonic effect combined with the greater interaction between cells and AgNPs-ZnPs systems resulted in an efficient and improved fungal inactivation. This study provides insight into the application of AgNPs in PDI and helps diversify our antifungal arsenal, encouraging further developments toward inactivation of resistant Candida spp.

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Section: Resultsmentioning

confidence: 84%

“…In this way, spectral changes may suggest that there was an interaction between ZnPs and AgNPs. 9 , 32–34 …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel Strategy Based on Zn(II) Porphyrins and Silver Nanoparticles to Photoinactivate Candida albicans

Raposo¹,

Souza²,

Santana³

et al. 2023

IJN

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“…Further augmentation of PDT activity was reported by Rodrigues et al for the use of MB with nanoprisms. 66 Macla et al described an Ag nanocube with 12× times more ROS generation than a spherical structure. 67 Moreover, different PDT efficiencies were reported for different Ag NP shapes.…”

Section: Plasmonic Nanoparticle-mediated Photodynamic Therapy Of Bact...mentioning

confidence: 99%

“…Santos et al constructed nano prisms and reported 30% more ROS produced at the prismatic tips when evaluated using MDR S. aureus . Further augmentation of PDT activity was reported by Rodrigues et al for the use of MB with nanoprisms . Macla et al described an Ag nanocube with 12× times more ROS generation than a spherical structure .…”

Section: Plasmonic Nanoparticle-mediated Photodynamic Therapy Of Bact...mentioning

confidence: 99%

Review of Photoresponsive Plasmonic Nanoparticles That Produce Reactive Chemical Species for Photodynamic Therapy of Cancer and Bacterial Infections

Singh

Mazumder

Vincy

et al. 2023

ACS Appl. Nano Mater.

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Increased use of classical drug therapy, including the administration of antibiotics and anticancer drugs, has led to multidrug resistance. Overcoming this resistance requires alternative therapies. Photodynamic therapy is used extensively to combat numerous ailments by killing cells by producing reactive chemical species (RCS). Plasmonic nanomaterials are excellent candidates for bactericidal and neoplastic agents due to their specialized optical properties and capacity to generate RCS. Plasmonic nanomaterials are in great demand for drug delivery, medical diagnostic applications, electronic semiconductors, biomolecular sensing, surface-enhanced Raman spectroscopy, enhancement of materials, and catalysis. This review focuses on plasmonic nanoparticle therapy for bacterial infections and cancers. In particular, mechanisms for RCS formation, toxicity, immunogenicity, and biodegradability of plasmonic nanomaterials are discussed. These materials may become important agents for treating bacterial infections and cancer in the near future, in combination with proper targeting agents and conjugation with biocompatible molecules.

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Strengthening collaborations at the Biology-Physics interface: trends in antimicrobial photodynamic therapy

et al. 2023

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Silver nanoprisms as plasmonic enhancers applied in the photodynamic inactivation of Staphylococcus aureus isolated from bubaline mastitis

Cited by 8 publications

References 70 publications

A Novel Strategy Based on Zn(II) Porphyrins and Silver Nanoparticles to Photoinactivate Candida albicans

A Novel Strategy Based on Zn(II) Porphyrins and Silver Nanoparticles to Photoinactivate Candida albicans

Review of Photoresponsive Plasmonic Nanoparticles That Produce Reactive Chemical Species for Photodynamic Therapy of Cancer and Bacterial Infections

Strengthening collaborations at the Biology-Physics interface: trends in antimicrobial photodynamic therapy

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