Silver nanoparticles synthesised by using Iranian <i>Mentha pulegium</i> leaf extract as a non-cytotoxic antibacterial agent

Gholami, Maryam; Azarbani, Farideh; Hadi, Faranak

doi:10.1080/10667857.2021.1906390

Cited by 9 publications

(16 citation statements)

References 33 publications

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“…Figure B shows the TEM image for biosynthesized AgNPs, which are mainly spherical in shape and have good dispersion and scattering in nature for a large proportion of the particles. It is obviously that the biosynthesized AgNPs have diameters roughly in the range of 10–20 nm basically in accordance with DLS results (15.7 ± 0.1 nm), which are smaller than those synthesized using Mentha pulegium extract under acidic condition. , …”

Section: Resultsmentioning

confidence: 71%

“…The IC 50 values of AgNPs against HCT116, HepG2, and HeLa cancer cell lines were determined by fitting the curve of the cell viability using the GraphPad Prism 8.0 software package, and the values were 9.0, 14.5, and 31.5 μg·mL –1 , respectively. The AgNPs synthesized by the Mentha pulegium extract herein displayed a higher anticancer activity than the AgNPs synthesized by Hadi Faranak using Iranian Mentha pulegium (∼100 μg·mL –1 for Hela and MCF-7), 46 and other traditional medicines with an anticancer effect, such as Iresine herbstii ( 60 ) (51 μg·mL –1 for Hela) and Cornus officinalis ( 31 ) (20.68 and 69.72 μg·mL –1 for HCT116 and HepG2, respectively). Additionally, these values were also comparable to those of Sea buckthorn ( 30 ) (8.77, 14.59, and 27.98 μg·mL –1 for HCT116, HepG2, and HeLa, respectively), indicating that the AgNPs biosynthesized using Mentha pulegium extract could be acted as candidate for anticancer drugs.…”

Section: Resultsmentioning

confidence: 89%

“…It is obviously that the biosynthesized AgNPs have diameters roughly in the range of 10–20 nm basically in accordance with DLS results (15.7 ± 0.1 nm), which are smaller than those synthesized using Mentha pulegium extract under acidic condition. 45 , 46 …”

Section: Resultsmentioning

confidence: 99%

“… 41 − 44 It is possible to fabricate AgNPs with superior bioactivities using Mentha pulegium . On this basis, Abdol-Khalegh Bordbar 45 and Hadi Faranak 46 have successfully synthesized AgNPs using Mentha pulegium leaf extract, which revealed significant inhibition of bacterial strains as well as the cancer cell lines but no cytotoxicity for human peripheral blood mononuclear cells (PBMCs). We noticed that both Abdol-Khalegh Bordbar and Hadi Faranak used the primary extract of the Mentha pulegium leaf, which is an acidic solution.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that Mentha pulegium contains a range of bioactive chemicals like essential oils, isomenthone, menthoacetate, peppermint isoflavourin, and rosmarinic acid, which exhibit a wide spectrum of antioxidant, antimicrobial, and anticancer activities. − It is possible to fabricate AgNPs with superior bioactivities using Mentha pulegium . On this basis, Abdol-Khalegh Bordbar and Hadi Faranak have successfully synthesized AgNPs using Mentha pulegium leaf extract, which revealed significant inhibition of bacterial strains as well as the cancer cell lines but no cytotoxicity for human peripheral blood mononuclear cells (PBMCs). We noticed that both Abdol-Khalegh Bordbar and Hadi Faranak used the primary extract of the Mentha pulegium leaf, which is an acidic solution.…”

Section: Introductionmentioning

confidence: 99%

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Green Fabrication of Bioactive Silver Nanoparticles Using Mentha pulegium Extract under Alkaline: An Enhanced Anticancer Activity

Wang

Wei

2021

ACS Omega

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Fabrication of silver nanoparticles (AgNPs) using Chinese herbal medicine is popular as the bioactive components included in them would generate potential synergistic effect with the metal nanoparticles. The leaf of Mentha pulegium , whose extract contains a range of phytochemicals and exhibits a wide spectrum of bioactivities, is used as Chinese herbal medicine after drying naturally. Thus, the green synthesis of AgNPs using Mentha pulegium has aroused interests from analysts. However, the biosynthesis of AgNPs under alkaline conditions and the biological activities remain elusive, where alkaline conditions may influence the physicochemical properties and the biological activities of biosynthesized AgNPs. In this study, we were stimulated to fabricate bioactive AgNPs using Mentha pulegium extract under alkaline conditions, accompanied by a systematic evaluation on the effect of biosynthesis parameters on the formation, average size, and polydispersity of AgNPs. Our results showed that alkaline conditions could accelerate the formation of AgNPs with a small average size but at a disadvantage to the polydispersity. Additionally, the as-prepared AgNPs had a hexagonal structure and spherical shape with an average size of 15.7 ± 0.1 nm, existing in the monodispersed form and revealing a high degree of stability. The AgNPs exhibited potent antioxidant and significant inhibitory activity for both bacterial and cancer cell lines. The MIC values of AgNPs for Staphylococcus aureus and Escherichia coli were both 50.0 μg·mL –1 , and the IC 50 values for HCT116, HepG2, and HeLa cells were 9.0, 14.5, and 31.5 μg·mL –1 , respectively. The AgNPs biosynthesized using M. pulegium under alkaline conditions, which had a smaller size and more surface loads, are entirely different with those synthesized under acidic conditions, and the anticancer activity increased significantly. The internalization of AgNPs inside these five cells displayed a variant trend with variable AgNPs concentrations, suggesting the different mechanism of cell death. For two pathogens, HCT116 and HepG2 cancer cell lines, both cell wall and intracellular damage may be responsible for the cell death. However, for Hela cell line the cell death may be rooted in oxidative stress or intracellular penetration. These results confirmed that the AgNPs biosynthesized from M. pulegium extract under alkaline conditions would act as better anticancer agents in biomedicine.

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Section: Resultsmentioning

confidence: 71%