Silver Nanoparticles: Synthesis and Application for Nanomedicine

Lee, Sang Hun; Jun, Bong‐Hyun

doi:10.3390/ijms20040865

Cited by 994 publications

(630 citation statements)

References 143 publications

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“…The commonly used disinfectant povidone iodine is reported to have similar adverse effects and incorporates triiodide ions for the release of free iodine [48][49][50]. Silver nanoparticles have antimicrobial effects and are incorporated increasingly in many products, including surgical sutures [58,59]. Sustainability and cytotoxicity can be minimized by reducing AgNP content through combinations with other antimicrobials.…”

Section: Discussionmentioning

confidence: 99%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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Section: Discussionmentioning

confidence: 99%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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“…The SEM images also demonstrated the non-homogeneity of the particles in terms of their shape and size. All the possible spherical and irregular shapes such as truncated hexagonal, cylindrical, triangular, prismatic shapes of Ag NPs with varying particle sizes were found in the micrograph [31].…”

Section: Morphological and Compositional Analysis By Sem-edaxmentioning

confidence: 99%

Electrochemical properties of biogenic silver nanoparticles synthesized using Hagenia abyssinica (Brace) JF. Gmel. medicinal plant leaf extract

Murthy¹,

Desalegn²,

Ravikumar³

et al. 2020

Mater. Res. Express

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The biogenic/green silver nanoparticles (g-Ag NPs) were synthesised by using the extract of indigenous medicinal plant of Ethiopia, Hagenia abyssinica (Brace) JF. Gmel. leaf extract for the first time, to investigate the synergistic effect of biomolecules towards the enhancement of electrochemical properties of NPs. The synthesized g-Ag NPs were characterized by UV-visible, UV-DRS, FT-IR, XRD, SEM, EDXA, TEM, HRTEM and SAED techniques. The maximum absorbance, λ max was found to be 461 nm for g-Ag NPs due to surface plasmon resonance. The energy gap, E g of NPs, was found to be 2.31 eV. FTIR spectrum confirmed the presence of bioactive compounds responsible for possible capping and stabilisation of g-Ag NPs. The XRD analysis revealed that the g-Ag NPs are highly crystalline exhibiting sharp peaks for (111), (200), (220) and (311) planes in the diffraction pattern. SEM and TEM micrographs showed differently shaped Ag particles in addition to spherical shape. The average particle size of NPs was found to be 24.08 nm using imageJ analysis. EDX analysis confirmed the presence of Ag in the g-Ag NPs. In addition, the SAED pattern of g-Ag NPs presented concentric patterns for 4 major planes of crystalline silver. The d-spacing values of 0.2428 nm, 0.2126 nm, 0.1483 nm and 0.1263 nm corresponds to d 111 Ag, d 200 Ag, d 220 Ag and d 311 Ag lattice fringes respectively. The cyclic voltammetry (CV) results suggest that g-Ag NPs possess better electrochemical properties due to its lower charge transfer resistance value of 17 Ω. EIS studies too revealed better stability of g-Ag NPs as electrode materials.

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“…Among various inorganic compounds, applications of silver nanoparticles in the biomedical field is widespread and ever-increasing due to its low-cost, abundance, and fascinating properties 46,47 . As a consequence, silver nitrate was utilized in this study to embody GO's peroxidase-like and natural or carbocatalytic oxidation capabilities with inorganic compounds.…”

Section: Discussionmentioning

confidence: 99%

Preparation of graphene nanocomposites from aqueous silver nitrate using graphene oxide’s peroxidase-like and carbocatalytic properties

Garg

Papponen

Johansson

et al. 2020

Sci Rep

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the present study evaluates the role of graphene oxide's (Go's) peroxidase-like and inherent/ carbocatalytic properties in oxidising silver nitrate (AgNO 3 ) to create graphene nanocomposites with silver nanoparticles (GO/Ag nanocomposite). Activation of peroxidase-like catalytic function of Go required hydrogen peroxide (H 2 o 2 ) and ammonia (nH 3 ) in pH 4.0 disodium hydrogen phosphate (na 2 Hpo 4 ). Carbocatalytic abilities of GO were triggered in pH 4.0 deionised distilled water (ddH 2 O). Transmission electron microscope (TEM), scanning electron microscope (SEM), cyclic voltammetry (CV) and UV-Vis spectroscopy aided in qualitatively and quantitatively assessing GO/Ag nanocomposites. teM and SeM analysis demonstrated the successful use of Go's peroxidase-like and carbocatalytic properties to produce GO/Ag nanocomposite. UV-Vis analysis indicated a higher yield in optical density values for GO/Ag nanocomposites created using GO's carbocatalytic ability rather than its peroxidaselike counterpart. Additionally, CV demonstrated that GO/Ag nanocomposite fabricated here is a product of an irreversible electrochemical reaction. Our study outcomes show new opportunities for GO as a standalone catalyst in biosensing. We demonstrate a sustainable approach to obtain graphene nanocomposites exclusive of harmful chemicals or physical methods.Remarkable optical, thermal, mechanical, and electrical properties of graphene have captivated the imaginations of scientists worldwide 1-4 . Graphene is an ideal composite counterpart to create flexible electronics 5,6 , design batteries with enhanced storage capability 7 , prevent steel corrosion 8 , and shield aircraft from heat 9 . Real-world graphene applications have originated across several industries like the Inov-8 running trainers that employ thermal and mechanical qualities of graphene to improve their durability 10 . The famous sports equipment manufacturer, HEAD applied graphene to create stronger tennis rackets with lighter weight distribution 10 . The BAC-Mono formula racing car also uses graphene to boost strength and reduce the mass of its body parts by 20% 11 . Miniaturization of biochemical assays using graphene-based sensors for research and clinical purposes is now a reality with AGILER100 12

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Silver Nanoparticles: Synthesis and Application for Nanomedicine

Cited by 994 publications

References 143 publications

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Electrochemical properties of biogenic silver nanoparticles synthesized using Hagenia abyssinica (Brace) JF. Gmel. medicinal plant leaf extract

Preparation of graphene nanocomposites from aqueous silver nitrate using graphene oxide’s peroxidase-like and carbocatalytic properties

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