Silver nanoparticles modified nanocapsules for ultrasonically activated drug delivery

Sundaramurthy, Anandhakumar; Mahalakshmi, V.; Raichur, Ashok M.

doi:10.1016/j.msec.2012.07.006

Cited by 41 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, the capsules without NPs were only deformed after sonication. For a homogenous distribution of NPs, in situ synthesis of silver NPs in PAH/ DS capsules has also been reported [149]. The burst release of FITC-dextran within 5 s was observed upon exposure to ultrasonic irradiation of 170 W and 50 Hz.…”

Section: Laser Light Irradiationmentioning

confidence: 89%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

View full text Add to dashboard Cite

Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine, theranostics and gene therapy. The most essential attributes of a drug delivery system are considered to be multi-functionality and stimuli responsiveness against a range of external and internal stimuli. Apart from the highly explored strong polyelectrolytes, weak polyelectrolytes offer great versatility with a highly controllable architecture, unique stimuli responsiveness and easy tuning of the properties for intracellular delivery of cargo. This review describes the progress in the preparation, functionalization and applications of capsules made of weak polyelectrolytes or their combination with biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in potential applications.

show abstract

Section: Laser Light Irradiationmentioning

confidence: 89%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

View full text Add to dashboard Cite

show abstract

“…As a consequence of the difficulty encountered during AgNP synthesis and the concerns regarding the toxicity and reduced stability of nanosilver-based systems when functionalized according to conventional salt-aging techniques, silver is not extensively used in nanoparticle-based drug-delivery applications, instead being replaced with gold or other nanomaterials [ 88 ]. An excellent triggerable and tunable nanosystem for drug-delivery applications should be easy to develop from readily available components, exhibit optimal responsiveness, and be compatible with more than one trigger [ 89 ]. Moreover, such a particular drug-delivery [ 90 ] platform should not only provide suitable and adjustable drug loading and releasing profiles, but should also enable [ 70 ] maximal therapeutic efficiency at concentrations below that of the sole biosubstance with side-effect minimization [ 91 , 92 ].…”

Section: Silver Nanoparticles For Drug-delivery Systemsmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

View full text Add to dashboard Cite

During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

show abstract

“…This trend was preserved for all samples, indicating no visible carrier effect on the morphology of the silver nanoparticles deposited on the nanofibers. 1 BET surface area, calculated using experimental points at relative pressures of (P/P0) 0.035-0.31, where P and P0 denote the equilibrium and saturation pressures of nitrogen, respectively; 2 Total pore volume calculated from the nitrogen volume adsorbed at P/P0 = 0.99; 3 Pore-size distribution curves were obtained from the adsorption branch using the Barrett-Joyner-Halenda (BJH) model with cylindrical pores.…”

Section: Microstructural Characterization Of Ag/cs/silica Nanofibersmentioning

confidence: 99%

“…Hybrid nanocomposites are an important platform for the preparation of new materials with advanced properties [1][2][3][4][5][6][7][8]. Noble metal nanostructures encapsulated within or deposited on biopolymers are of particular interest for human [9,10], sensing [11,12], and catalytic applications [13][14][15][16], as these types of materials combine the physicochemical features of noble metal nanostructures and the biological features of polymers [17,18].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

View full text Add to dashboard Cite

A simple, low-cost, and reproducible method for creating materials with even silver nanoparticles (AgNP) dispersion was established. Chitosan nanofibers with silica phase (CS/silica) were synthesized by an electrospinning technique to obtain highly porous 3D nanofiber scaffolds. Silver nanoparticles in the form of a well-dispersed metallic phase were synthesized in an external preparation step and embedded in the CS/silica nanofibers by deposition for obtaining chitosan nanofibers with silica phase decorated by silver nanoparticles (Ag/CS/silica). The antibacterial activity of investigated materials was tested using Gram-positive and Gram-negative bacteria. The results were compared with the properties of the nanocomposite without silver nanoparticles and a colloidal solution of AgNP. The minimum inhibitory concentration (MIC) of obtained AgNP against Staphylococcus aureus (S. aureus) ATCC25923 and Escherichia coli (E. coli) ATCC25922 was determined. The physicochemical characterization of Ag/CS/silica nanofibers using various analytical techniques, as well as the applicability of these techniques in the characterization of this type of nanocomposite, is presented. The resulting Ag/CS/silica nanocomposites (Ag/CS/silica nanofibers) were characterized by small angle X-ray scattering (SAXS), X-ray diffraction (XRD), and atomic force microscopy (AFM). The morphology of the AgNP in solution, both initial and extracted from composite, the properties of composites, the size, and crystallinity of the nanoparticles, and the characteristics of the chitosan fibers were determined by electron microscopy (SEM and TEM).

show abstract

Silver nanoparticles modified nanocapsules for ultrasonically activated drug delivery

Cited by 41 publications

References 26 publications

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Contact Info

Product

Resources

About