Silver Nanoparticles: Mechanism of Action and Probable Bio-Application

Михайлова, Е. О.

doi:10.3390/jfb11040084

Cited by 310 publications

(208 citation statements)

References 239 publications

(149 reference statements)

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“…Although the antimicrobial mechanism of biogenic AgNPs and chemically synthesized AgNPs is still unknown, several mechanisms can play a role in their biological activities. When synthesized with various plant extracts, AgNPs can physically attach to bacteria and even eukaryotic cell surfaces and disrupt their integrity [51]. Internalization of the cytoplasm, interaction with cellular organelles and macromolecules, and finally production of reactive oxygen species (ROS) are the main biological mechanisms of biogenic AgNPs in the literature [52].…”

Section: Antibacterial Effects Against a Baumanniimentioning

confidence: 99%

Antibacterial Effects of Green-Synthesized Silver Nanoparticles Using Ferula asafoetida against Acinetobacter baumannii Isolated from the Hospital Environment and Assessment of Their Cytotoxicity on the Human Cell Lines

Abootalebi

Mousavi

Hashemi

et al. 2021

Journal of Nanomaterials

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Acinetobacter baumannii (A. baumannii) is a dangerous nosocomial pathogen in intensive care units, causing fatal clinical challenges and mortality. In this study, the green synthesis of silver nanoparticles (AgNPs) using the extract of Ferula asafetida and the chemical synthesis of AgNPs were carried out to evaluate their effects on A. baumannii bacterial strain and a human adenocarcinoma cell line. The NPs were characterized using several techniques, including field emission-scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectrometry, UV-visible spectroscopy, and Fourier-transform infrared spectroscopy. After synthesis, the arrangement of AgNPs was confirmed based on the maximum absorption peak at 450 nm. The results showed that the AgNPs had a hexagonal structure. The antimicrobial activity of biogenic NPs significantly increased and reached a minimum inhibitory concentration of 2 μg/mL. The nanomaterials did not exhibit any toxic effects on the human cell line at certain concentrations and showed improvements compared to chemically synthesized AgNPs. However, at higher concentrations (100 μg/mL), the cytotoxicity increased. Finally, it was concluded that biosynthesized AgNPs had significant antimicrobial effects on A. baumannii isolated from intensive care units.

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Section: Antibacterial Effects Against a Baumanniimentioning

confidence: 99%

Antibacterial Effects of Green-Synthesized Silver Nanoparticles Using Ferula asafoetida against Acinetobacter baumannii Isolated from the Hospital Environment and Assessment of Their Cytotoxicity on the Human Cell Lines

Abootalebi

Mousavi

Hashemi

et al. 2021

Journal of Nanomaterials

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“…A range of AgNPs, including nanowires, pyramids, octahedral, tabular prisms and cubes, can be obtained by using many objects for the creation of NPs. AgNPs’ shape and size mainly depend on the response variables such as pH, temperature and concentration of Ag; meanwhile, in biological synthesis, they largely depend on the materials used for the production of AgNPs [ 9 ]. The concept of “green chemistry” has been expanding since the mid-1990s and researchers are seeking greener and more sustainable methods of AgNP synthesis.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Biosynthesis, Characterization, Antimicrobial Activities, Applications, Cytotoxicity and Safety Issues: An Updated Review

et al. 2021

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Rapid advances in nanotechnology have led to its emergence as a tool for the development of green synthesized noble metal nanoparticles, especially silver nanoparticles (AgNPs), for applications in diverse fields such as human health, the environment and industry. The importance of AgNPs is because of their unique physicochemical and antimicrobial properties, with a myriad of activities that are applicable in various fields, including the pharmaceutical industry. Countries with high biodiversity require the collection and transformation of information about biological assets into processes, associations, methods and tools that must be combined with the sustainable utilization of biological diversity. Therefore, this review paper discusses the applicable studies of the biosynthesis of AgNPs and their antimicrobial activities towards microorganisms in different areas viz. medicine and agriculture. The confirmed antiviral properties of AgNPs promote their applicability for SARS-CoV-2 treatment, based on assimilating the virus’ activities with those of similar viruses via in vivo studies. In this review, an insight into the cytotoxicity and safety issues of AgNPs, along with their future prospects, is also provided.

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“…There are also nanoparticles embedded in the structure of other metals [ 6 ]. Silver nanoparticles (AgNPs) have a diameter not exceeding 100 nm and consist of about 20–15,000 atoms [ 7 , 8 ]. Nanoparticles smaller than 10 nm penetrate cell membranes easier and faster [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Silver nanoparticles (AgNPs) have a diameter not exceeding 100 nm and consist of about 20–15,000 atoms [ 7 , 8 ]. Nanoparticles smaller than 10 nm penetrate cell membranes easier and faster [ 6 , 8 ]. The unique design of the Ag crystal unit cell (cube with 4 Ag atoms) allows oxygen adsorption, which can be released into the environment [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

All That Glitters Is Not Silver—A New Look at Microbiological and Medical Applications of Silver Nanoparticles

Kowalczyk

Szymczak

Maciejewska

et al. 2021

IJMS

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Silver and its nanoparticles (AgNPs) have different faces, providing different applications. In recent years, the number of positive nanosilver applications has increased substantially. It has been proven that AgNPs inhibit the growth and survival of bacteria, including human and animal pathogens, as well as fungi, protozoa and arthropods. Silver nanoparticles are known from their antiviral and anti-cancer properties; however, they are also very popular in medical and pharmaceutical nanoengineering as carriers for precise delivery of therapeutic compounds, in the diagnostics of different diseases and in optics and chemistry, where they act as sensors, conductors and substrates for various syntheses. The activity of AgNPs has not been fully discovered; therefore, we need interdisciplinary research to fulfil this knowledge. New forms of products with silver will certainly find application in the future treatment of many complicated and difficult to treat diseases. There is still a lack of appropriate and precise legal condition regarding the circulation of nanomaterials and the rules governing their safety use. The relatively low toxicity, relative biocompatibility and selectivity of nanoparticle interaction combined with the unusual biological properties allow their use in animal production as well as in bioengineering and medicine. Despite a quite big knowledge on this topic, there is still a need to organize the data on AgNPs in relation to specific microorganisms such as bacteria, viruses or fungi. We decided to put this knowledge together and try to show positive and negative effects on prokaryotic and eukaryotic cells.

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Silver Nanoparticles: Mechanism of Action and Probable Bio-Application

Abstract: This review is devoted to the medical application of silver nanoparticles produced as a result of “green” synthesis using various living organisms (bacteria, fungi, plants). The proposed mechanisms of AgNPs synthesis and the action mechanisms on target cells are highlighted.

Cited by 310 publications

References 239 publications

Antibacterial Effects of Green-Synthesized Silver Nanoparticles Using Ferula asafoetida against Acinetobacter baumannii Isolated from the Hospital Environment and Assessment of Their Cytotoxicity on the Human Cell Lines

Antibacterial Effects of Green-Synthesized Silver Nanoparticles Using Ferula asafoetida against Acinetobacter baumannii Isolated from the Hospital Environment and Assessment of Their Cytotoxicity on the Human Cell Lines

Silver Nanoparticles Biosynthesis, Characterization, Antimicrobial Activities, Applications, Cytotoxicity and Safety Issues: An Updated Review

All That Glitters Is Not Silver—A New Look at Microbiological and Medical Applications of Silver Nanoparticles

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