Silver nanoparticles induce oxidative stress, apoptosis and impaired steroidogenesis in ovarian granulosa cells of cattle

Tabandeh, Mohammad Reza; Samie, Kosar Abbasi; Mobarakeh, Erfan Sadeghi; Khadem, Mohammad Darvish; Jozaie, Sadegh

doi:10.1016/j.anireprosci.2021.106908

Cited by 10 publications

(5 citation statements)

References 35 publications

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“…Therefore, the new connection established in the HFRT-AOP network may represent an emergent path in DEHP-induced female reproductive dysfunction. We have also found that this possible DEHP emergent path is supported by several lines of evidence showing a concomitant increase in oxidative stress and a decrease in E2 production in granulosa cells (Cui et al 2022;Tabandeh et al 2022;Tripathi et al 2019a;Zaidi et al 2021). Secondly, this pathway implicates oxidative stress as a potential MIE of DEHP-induced human female reproductive toxicity.…”

Section: Mapping Dehp To the Hfrt-aop Networksupporting

confidence: 79%

Mapping DEHP to the adverse outcome pathway network for human female reproductive toxicity

et al. 2022

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Adverse outcome pathways (AOPs) and AOP networks are tools for mechanistic presentation of toxicological effects across different levels of biological organization. These tools are used to better understand how chemicals impact human health. In this study, a four-step workflow was used to derive the AOP network of human female reproductive toxicity (HFRT-AOP) from five AOPs available in the AOP-Wiki and ten AOPs obtained from the literature. Standard network analysis identified key events (KEs) that are point of convergence and divergence, upstream and downstream KEs, and bottlenecks across the network. To map di-(2-ethylhexyl) phthalate (DEHP) to the HFRT-AOP network, we extracted DEHP target genes and proteins from the Comparative Toxicogenomic and the CompTox Chemicals Dashboard databases. Enriched GO terms analysis was used to identify relevant biological processes in the ovary that are DEHP targets, whereas screening of scientific literature was performed manually and automatically using AOP-helpFinder. We combined this information to map DEHP to HFRT-AOP network to provide insight on the KEs and system-level perturbations caused by this endocrine disruptor and the emergent paths. This approach can enable better understanding of the toxic mechanism of DEHP-induced human female reproductive toxicity and reveal potential novel DEHP female reproductive targets for experimental studies.

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Section: Mapping Dehp To the Hfrt-aop Networksupporting

confidence: 79%

Mapping DEHP to the adverse outcome pathway network for human female reproductive toxicity

et al. 2022

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“…As for the use of higher doses of nanosilver in calves, it is necessary to take into account its negative effect, which can be manifested in a decrease in mobility, viability and violation of the integrity of the membrane of spermatozoa, as well as cause histopathological changes in the epithelia of the testicles, inflammatory processes of the epididymis and hyperplasia of the prostate gland in males nanosilver in high, close to toxic, doses also accumulates in the ovaries and uterus of females, causing polycystic ovarian changes, follicular atresia, inflammation, apoptosis and necrosis (Dianová etal., 2022), and also disrupts the synthesis of steroid hormones and the function of the reproductive system (Tabandeh et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

The effect of colloidal silver on clinical, morphological parameters and mineral composition of blood of calves

Шевченко

2023

Acta fytotechn zootechn

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Licensed under a Creative Commons Attribution 4.0 International LicenseThe problem of the calf livestock to be preserved under the use restriction conditions of the antibiotics in case of the infectious diseases requires the search for alternative antimicrobial agents, to which the nanocompounds of the noble metals are belonged. The influence of the colloid silver solution on the indicators of the clinical condition, mineral turnover and morphological composition of the blood of the black-pied Holstein calves aged from birth to 30 days had been analyzed. It had been established that the calf rearing with the colloid silver solution composed of colostrum (milk) at a dose of 1.0 and 2.0 mg/l from the 1 to the 10 day every twenty-four hours, from the 11 to the 30 day, which is carried out once a decade, does not influence on the indicators of the clinical condition, but dose-dependently contributes to the increasing silver content in the blood. Nanosilver at a dose of 2.0 mg/l of colostrum causes the increasing iron and zinc accumulation in the blood of the calves on the 3 day after birth. With the increasing calf age up to 30 days as well as with the increasing oral use interval of the colloid silver solution, its influence on the exchange of zinc, iron and copper in the blood is decreased. On the 3 and 10 day after the calf rearing with the colloid silver solution at a dose of 1.0 mg/l, the erythrocyte number reduction in their blood was found by 15.0% and 12.3%, the dose of nanosilver of 2.0 mg/l of colostrum causes a similar influence only on the 10 day. On the 30 day after the increasing interval of the calf rearing the erythrocyte number in the blood of both studied groups had been equal with the control one. The leukocyte number in the blood of the healthy calves practically did not depend on the dose of the colloid silver, as well as on its use period. The dose of the colloid silver equal to 1.0 mg/l of colostrum (milk) influences on the blood leukogram in a lesser extent than the dose equal to 2.0 mg/l, but both drug doses for 30 day increase the lymphocyte percentage in the blood of the healthy calves. The obtained results make it possible to select an effective dose and interval of nanosilver application to the calves, taking into account the indicators of their clinical condition, mineral turnover and morphological composition of the blood, as well as to consider it as a prophylactic agent in case of the infectious diseases.

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“…Similar results were also obtained in experiments on pigs; moreover, the cytotoxicity of AgNPs was found to increase as the particle size decreased [ 221 ]. Silver nanoparticles may also induce oxidative stress, apoptosis, and the disruption of steroidogenesis in bovine granulosa cells [ 222 ]. Cadmium-based quantum dots (QD705) induced persistent inflammation and formation of granulomas in mouse lungs; pegylation of those NPs did not prevent the side effects [ 223 , 224 ].…”

Section: Risks and Hazards Of Nanotechnology Applications In Veterina...mentioning

confidence: 99%

Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine

Danchuk,

Levchenko,

da Silva Mesquita

et al. 2023

Pharmaceutics

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In recent decades, nanotechnology has been rapidly advancing in various fields of human activity, including veterinary medicine. The review presents up-to-date information on recent advancements in nanotechnology in the field and an overview of the types of nanoparticles used in veterinary medicine and animal husbandry, their characteristics, and their areas of application. Currently, a wide range of nanomaterials has been implemented into veterinary practice, including pharmaceuticals, diagnostic devices, feed additives, and vaccines. The application of nanoformulations gave rise to innovative strategies in the treatment of animal diseases. For example, antibiotics delivered on nanoplatforms demonstrated higher efficacy and lower toxicity and dosage requirements when compared to conventional pharmaceuticals, providing a possibility to solve antibiotic resistance issues. Nanoparticle-based drugs showed promising results in the treatment of animal parasitoses and neoplastic diseases. However, the latter area is currently more developed in human medicine. Owing to the size compatibility, nanomaterials have been applied as gene delivery vectors in veterinary gene therapy. Veterinary medicine is at the forefront of the development of innovative nanovaccines inducing both humoral and cellular immune responses. The paper provides a brief overview of current topics in nanomaterial safety, potential risks associated with the use of nanomaterials, and relevant regulatory aspects.

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Silver nanoparticles induce oxidative stress, apoptosis and impaired steroidogenesis in ovarian granulosa cells of cattle

Cited by 10 publications

References 35 publications

Mapping DEHP to the adverse outcome pathway network for human female reproductive toxicity

Mapping DEHP to the adverse outcome pathway network for human female reproductive toxicity

The effect of colloidal silver on clinical, morphological parameters and mineral composition of blood of calves

Meeting Contemporary Challenges: Development of Nanomaterials for Veterinary Medicine

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