Silver-nanoparticles as plasmon-resonant enhancers for eumelanin's photoacoustic signal in a self-structured hybrid nanoprobe

Silvestri, Brigida; Armanetti, Paolo; Sanità, Gennaro; Vitiello, Giuseppe; Lamberti, Annalisa; Calı̀, Gaetano; Pezzella, Alessandro; Luciani, Giuseppina; Menichetti, Luca; Luin, Stefano; d’Ischia, Marco

doi:10.1016/j.msec.2019.04.066

Cited by 32 publications

(56 citation statements)

References 57 publications

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“…Non-organic nanoparticles also can poses the core-shell structure by coating with other metals or polymers for additional stabilisation/functionality to use , for example, in drug delivery [57], imaging techniques [58], medicine [59] etc. Overall, the effects of surface topology and non-uniform charge distribution becomes very important on the nanometre length scale.…”

Section: Experimental Studies Of Nano-particle Interactionsmentioning

confidence: 99%

Interactions between nanoparticles in nanosuspension

Kovalchuk

Johnson

Соболев

et al. 2019

Advances in Colloid and Interface Science

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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Section: Experimental Studies Of Nano-particle Interactionsmentioning

confidence: 99%

Interactions between nanoparticles in nanosuspension

Kovalchuk

Johnson

Соболев

et al. 2019

Advances in Colloid and Interface Science

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“…To fully utilize this potential, a series of photoabsorbing agents including noble metal nanocrystals, polymer nanoparticles, and 2D nanosheets have been developed as PA contrast agents . For instance, metal Ag nanoparticles conjugated with bioavailable melanin were synthesized as biocompatible hybrid nanoprobes to greatly enhance PA imaging, demonstrating high potential for cancer diagnosis and therapy . Among them, monoelemental nanoparticles, consisting of single element, have received particular attention.…”

Section: Introductionmentioning

confidence: 99%

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Miao

Liu

Wang

et al. 2019

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Elemental tantalum is a well‐known biomedical metal in clinics due to its extremely high biocompatibility, which is superior to that of other biomedical metallic materials. Hence, it is of significance to expand the scope of biomedical applications of tantalum. Herein, it is reported that tantalum nanoparticles (Ta NPs), upon surface modification with polyethylene glycol (PEG) molecules via a silane‐coupling approach, are employed as a metallic photoacoustic (PA) contrast agent for multiwavelength imaging of tumors. By virtue of the broad optical absorbance from the visible to near‐infrared region and high photothermal conversion efficiency (27.9%), PEGylated Ta NPs depict high multiwavelength contrast capability for enhancing PA imaging to satisfy the various demands (penetration depth, background noise, etc.) of clinical diagnosis as needed. Particularly, the PA intensity of the tumor region postinjection is greatly increased by 4.87, 7.47, and 6.87‐fold than that of preinjection under 680, 808, and 970 nm laser irradiation, respectively. In addition, Ta NPs with negligible cytotoxicity are capable of eliminating undesirable reactive oxygen species, ensuring the safety for biomedical applications. This work introduces a silane‐coupling strategy for the surface engineering of Ta NPs, and highlights the potential of Ta NPs as a biocompatible metallic contrast agent for multiwavelength photoacoustic image.

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“…Self-assembly into multi-cluster architectures of Ag in a hybrid melanin-silica phase resulted in an enhanced photoacoustic contrast of great promise for PAI application. Furthermore, the hybrid phase is a versatile chemical platform which can be easily functionalized with a large set of bioactive molecules ( Silvestri et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism

Sanità

Armanetti

Silvestri

et al. 2020

Front. Bioeng. Biotechnol.

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Bioconjugation of a recently developed photoacoustic nanoprobe, based on silica-templated eumelanin-silver hybrid nanoparticles (MelaSil_Ag-NPs), with human serum albumin (HSA) is disclosed herein as an efficient and practical strategy to improve photostability and to perform SPARC mediated internalization in breast cancer cells. Modification of NPs with HSA induced a slight viability decrease in breast cancer cells (HS578T) and normal breast cells (MCF10a) when incubated with HSA-NPs up to 100 μg/mL concentration for 72 h and a complete suppression of hemotoxicity for long incubation times. Uptake experiments with MelaSil_Ag-HSA NPs indicated very high and selective internalization via SPARC in HS578T (SPARC positive cells) but not in MCF10a (SPARC negative cells), as evaluated by using endocytosis inhibitors. The binding of SPARC to HSA was confirmed by Co-IP and Dot-blot assays. Additional studies were performed to analyze the interaction of MelaSil_Ag-HSA NPs with protein corona. Data showed a dramatic diminution of interacting proteins in HSA conjugated NPs compared to bare NPs. HSA-coated MelaSil_Ag-NPs are thus disclosed as a novel functional nanohybrid for potential photoacoustic imaging applications.

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Silver-nanoparticles as plasmon-resonant enhancers for eumelanin's photoacoustic signal in a self-structured hybrid nanoprobe

Cited by 32 publications

References 57 publications

Interactions between nanoparticles in nanosuspension

Interactions between nanoparticles in nanosuspension

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism

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