Silver nanoparticles as a new generation of antimicrobials

Rai, Mahendra; Yadav, Alka; Gade, Aniket

doi:10.1016/j.biotechadv.2008.09.002

Cited by 4,923 publications

(2,911 citation statements)

References 55 publications

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“…The main metal and metal oxide nanoparticles are based on silver, copper, copper oxide and zinc oxide (Moritz and Geszke-Moritz 2013). Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, silver sulfadiazine for the treatment of burns, wounds and several bacterial infections (Rai et al 2009). However, silver nanoparticles have some risks as the exposure to silver can cause agyrosis (Rai et al 2009) and it is toxic to mammalian cells (Gong et al 2007) unless if used in minute concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, silver sulfadiazine for the treatment of burns, wounds and several bacterial infections (Rai et al 2009). However, silver nanoparticles have some risks as the exposure to silver can cause agyrosis (Rai et al 2009) and it is toxic to mammalian cells (Gong et al 2007) unless if used in minute concentrations. Copper and its compounds have also been used for centuries as effective antibacterial, antifungal and antiviral agents (Ingle et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Assessing the efficacy of zinc oxide nanoparticles against Penicillium expansum by automated turbidimetric analysis

2017

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Public concerns about food safety have triggered a worldwide implementation of new legislations aimed at banning many of the most popular food conventional antifungal treatments. There is therefore an urgent need to identify novel and safer solutions to prevent fungal contamination of food. The antifungal effect of zinc oxide nanoparticles (ZnO NPs) against the postharvest pathogenic fungus Penicillium expansum has been investigated in this study. An automated turbidimetric assay, with a standard 96-well microplate, has been developed and optimised regarding the selection of the inoculum size in order to collect sequential optical density measurements. Data were processed by the updated version of the Lambert Pearson model to estimate the minimum inhibitory concentration and the non-inhibitory concentration values which were found to be 9.8 and 1.8 mM (i.e. 798 and 147 ppm), respectively. The current results show that turbidimetry is a reliable technique for assessing the antifungal activity of metal nanoparticles and that zinc oxide (ZnO) is an effective fungicide which can be potentially used to control food safety.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing the efficacy of zinc oxide nanoparticles against Penicillium expansum by automated turbidimetric analysis

2017

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“…One promising alternative which has been proposed is nanosilver [23]. Metallic nanoparticles in general have been reported to have broad spectrum activity against both Gram-positive and Gram-negative bacteria including antibiotic resistant bacteria like MRSA and MRSE [2,18,20].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of nano-silver: A cautionary approach to ionic interference

Sheehy¹,

Casey²,

Murphy³

et al. 2015

Journal of Colloid and Interface Science

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a b s t r a c tHypothesis: Metallic nanoparticles such as nano-silver have found many applications as alternative antimicrobials in recent years. However methods for determining their proposed antimicrobial activity have received little attention to date. The disk diffusion assay is commonly used as a demonstration of antimicrobial properties and is a regular feature in synthetic nanoparticle papers. The aim of this study was to assess its effectiveness in demonstrating the ''nanoparticle specific'' antimicrobial properties in the absence of ionic contributions from unreacted reducing agents and or impurities. Experiments: The disk diffusion assay was carried out on a range of silver nanoparticles, both in-house synthesised and commercially available, using Escherichia coli ATCC 25922 as a model organism. Results: Capped and purified nanoparticles show no antimicrobial activity despite claims to the contrary for this assay. Results will be discussed in terms of the need for researchers without a background in microbiology to understand the mechanism of antimicrobial action before choosing an assay. Also discussed is the importance understanding the physiochemical characteristics of when interpreting results. Finally the relevance of the results in terms establishing protocols for method development for 'nanoparticle specific' antimicrobial properties will also be considered.

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“…They get attached to the cell membrane and also penetrate inside the bacteria. The membrane of bacteria includes sulfur-containing proteins and the SNPs interact with these as well as with the phosphorus containing compounds similar to DNA (Rai et al 2009;Nabikhan et al 2010). The mechanism of the inhibitory effects of SNPs on microorganisms is partially known.…”

Section: Antibacterial Activity Of Snpsmentioning

confidence: 99%

Evaluation of plant-mediated Silver nanoparticles synthesis and its application in postharvest Physiology of cut Flowers

Solgi

2014

Physiol Mol Biol Plants

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Today the use of silver nanoparticles is becoming increasingly widespread due to their wide applications as antimicrobial agent. Green synthesis of silver nanoparticles (SNPs) using the petal extract of saffron (Crocus sativus) as a reducing agent from 5 mM AgNO 3 has been investigated in this work. Diverse petal extracts quantities and reaction times were used for the synthesis of SNPs. The resulting SNPs were characterized by means of UV-Vis, XRD and FTIR techniques. SNPs were synthesized rapidly within 30 min of incubation period and synthesized SNPs showed an absorption peak at 380-400 nm in the UV-Vis spectrum. XRD spectrum confirmed the formation of metallic silver, too. Green synthesized SNPs were used as antimicrobial agent against three bacterial genera of Bacillus, Pseudomonas and Acinetobacter which contaminate preservative solution of cutflowers, too. According to the results biosynthesized SNPs using saffron petals successfully controlled these bacteria and have made them promising candidates as new generation of antimicrobials. This route is rapid, simple without any hazardous chemicals and economical to synthesized SNPs.

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Silver nanoparticles as a new generation of antimicrobials

Cited by 4,923 publications

References 55 publications

Assessing the efficacy of zinc oxide nanoparticles against Penicillium expansum by automated turbidimetric analysis

Assessing the efficacy of zinc oxide nanoparticles against Penicillium expansum by automated turbidimetric analysis

Antimicrobial properties of nano-silver: A cautionary approach to ionic interference

Evaluation of plant-mediated Silver nanoparticles synthesis and its application in postharvest Physiology of cut Flowers

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