Silver nanocubes monolayers as a SERS substrate for quantitative analysis

Zhou, Ziang; Bai, Xiuhui; Li, Peishen; Wang, Changzheng; Guo, Ming; Zhang, Yang; Ding, Peiren; Chen, Shaowei; Wu, Yonggang; Wang, Qiang

doi:10.1016/j.cclet.2020.10.021

Cited by 28 publications

(9 citation statements)

References 34 publications

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“…The RSD values obtained were 10.49% and 4.01% for the protein peaks, 9.38% and 3.1% for lipid peaks, and 7.19% and 7.62% for nucleic acid peaks, respectively. Conventional noble metal-based sensors do not usually offer high reproducibility required for a biosensor. − We were able to eliminate this drawback by using 3D multilayered networks of Ni-NiO-based nanostructures. All the RSD values measured were below 10%, indicating distinctive SERS signal reproducibility.…”

Section: Resultsmentioning

confidence: 99%

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

et al. 2022

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Brain cancers, one of the most fatal malignancies, require accurate diagnosis for guided therapeutic intervention. However, conventional methods for brain cancer prognosis (imaging and tissue biopsy) face challenges due to the complex nature and inaccessible anatomy of the brain. Therefore, deep analysis of brain cancer is necessary to (i) detect the presence of a malignant tumor, (ii) identify primary or secondary origin, and (iii) find where the tumor is housed. In order to provide a diagnostic technique with such exhaustive information here, we attempted a liquid biopsy-based deep surveillance of brain cancer using a very minimal amount of blood serum (5 μL) in real time. We hypothesize that holistic analysis of serum can act as a reliable source for deep brain cancer surveillance. To identify minute amounts of tumor-derived material in circulation, we synthesized an ultrasensitive 3D nanosensor, adopted SERS as a diagnostic methodology, and undertook a DEEP neural network-based brain cancer surveillance. Detection of primary and secondary tumor achieved 100% accuracy. Prediction of intracranial tumor location achieved 96% accuracy. This modality of using patient sera for deep surveillance is a promising noninvasive liquid biopsy tool with the potential to complement current brain cancer diagnostic methodologies.

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Section: Resultsmentioning

confidence: 99%

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

et al. 2022

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“…The SPR characteristics of Ag NPs are a wide range of use for sensing and imaging research. Due to their obvious surface plasmon resonance (SPR), electromagnetic solid field enhancement, strong optical response and strong SRES activity, Ag NPs can enhance the weak medical detection signal (such as tumor cells), which can be used to detect tumor cells [34] . 3D highly ordered Ag NPs coated silica nanoparticles are exploited as novel SERS substrate [35] .…”

Section: Caner Theranosticsmentioning

confidence: 99%

“…Due to their obvious surface plasmon resonance (SPR), electromagnetic solid field enhancement, strong optical response and strong SRES activity, Ag NPs can enhance the weak medical detection signal (such as tumor cells), which can be used to detect tumor cells. [34] 3D highly ordered Ag NPs coated silica nanoparticles are exploited as novel SERS substrate. [35] Ag NPs can enhance signals of SERS to use for monitoring the targeted objects without any dye labeled.…”

Section: Surface-enhanced Raman Scattering-based Detectionmentioning

confidence: 99%

Silver Mesoporous Silica Nanoparticles: Fabrication to Combination Therapies for Cancer and Infection

Chen

Chang

et al. 2022

The Chemical Record

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The integration of silver nanoparticles (Ag NPs) with mesoporous silica nanoparticles (MSNs) protects the former from aggregation and promotes the controlled release of silver ions, resulting in therapeutic significance on cancer and infection. The unique size, shape, pore structure and silver distribution of silver mesoporous silica nanoparticles (Ag-MSNs) embellish them with the potential to perform combined imaging and therapeutic actions via modulating optical and drug release properties. Here, we comprehensively review the recent progress in the fabrication and application of Ag-MSNs for combination therapies for cancer and infection. We first elaborate on the fabrication of star-shaped structure, core-shell structure, and Janus structure Ag-MSNs. We then highlight Ag-MSNs as a multifunctional nanoplatform to surface-enhanced Raman scattering-based detection, non-photo-based cancer theranostics and photo-based cancer theranostics. In addition, we detail Ag-MSNs for combined antibacterial therapy via drug delivery and phototherapy. Overall, we summarize the challenges and future perspectives of Ag-MSNs that make them promising for diagnosis and therapy of cancer and infection.

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“…This indicates that the self-assembled Ag-NCs are effective as SERS substrates used in the analysis of complex molecular systems. The dyes R6G and CV generate characteristic SERS signals with varying intensities, which enables the simultaneous detection of double molecules [ 103 ]. Ag-NCs deposited on the surface of a quartz substrate can operate using the technique demonstrated by Mahmoud et al [ 104 ].…”

Section: Assemblies Of Noble Anisotropic Nanoparticlesmentioning

confidence: 99%

Recent Advances in Metallic Nanoparticle Assemblies for Surface-Enhanced Spectroscopy

Tim

Błaszkiewicz

Kotkowiak

2021

IJMS

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Robust and versatile strategies for the development of functional nanostructured materials often focus on assemblies of metallic nanoparticles. Research interest in such assemblies arises due to their potential applications in the fields of photonics and sensing. Metallic nanoparticles have received considerable recent attention due to their connection to the widely studied phenomenon of localized surface plasmon resonance. For instance, plasmonic hot spots can be observed within their assemblies. A useful form of spectroscopy is based on surface-enhanced Raman scattering (SERS). This phenomenon is a commonly used in sensing techniques, and it works using the principle that scattered inelastic light can be greatly enhanced at a surface. However, further research is required to enable improvements to the SERS techniques. For example, one question that remains open is how to design uniform, highly reproducible, and efficiently enhancing substrates of metallic nanoparticles with high structural precision. In this review, a general overview on nanoparticle functionalization and the impact on nanoparticle assembly is provided, alongside an examination of their applications in surface-enhanced Raman spectroscopy.

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Silver nanocubes monolayers as a SERS substrate for quantitative analysis

Cited by 28 publications

References 34 publications

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy

Silver Mesoporous Silica Nanoparticles: Fabrication to Combination Therapies for Cancer and Infection

Recent Advances in Metallic Nanoparticle Assemblies for Surface-Enhanced Spectroscopy

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