Silver Mesoporous Silica Nanoparticles: Fabrication to Combination Therapies for Cancer and Infection

He, Xuan; Chen, Fangman; Chang, Zhimin; Waqar, Kasim; Hu, Hanze; Zheng, Xiao; Wang, Yingshuai; Dong, Wen‐Fei; Yang, Chao

doi:10.1002/tcr.202100287

Cited by 10 publications

(5 citation statements)

References 110 publications

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“…Mesoporous silica nanoparticles are another important platform as inorganic drug delivery carriers for tumor treatment. They have the advantages of low side effects, good biocompatibility and stability, relatively uniform size and a large specific surface area [ 307 , 308 ]. For example, Jang and colleagues developed hybrid mesoporous silica nanoparticles functionalized with β-cyclodextrin and 4-(phenylazo) benzoic acid for improved on-demand drug release.…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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“…Noble metal NPs have made promising progress in areas including bioimaging, 124,125 photothermal tumor ablation, [126][127][128] PDT, 20,129,130 radiotherapy sensitization, 131,132 and recently developed nanozyme-based catalytic therapy, [133][134][135] due to their tunable optical properties, excellent catalytic activity and good biocompatibility. Among those noble metal NPs, ruthenium (Ru), 136 palladium (Pd), 137,138 silver (Ag), 139,140 platinum (Pt), 141,142 and gold (Au) 143,144 been reported to be loaded into MSNs to form various noble metal NPs/MSNs nanocomposites for biomedical applications (Fig. 4b).…”

Section: Msns-based Nanocompositesmentioning

confidence: 99%

Multifunctional mesoporous silica nanoparticles for biomedical applications

Xu,

Li,

Shi

et al. 2023

Sig Transduct Target Ther

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Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. Over the past two decades, researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques, demonstrating their adaptability to various biomedical application scenarios. With the continuous breakthroughs of MSNs in the fields of biosensing, disease diagnosis and treatment, tissue engineering, etc., MSNs are gradually moving from basic research to clinical trials. In this review, we provide a detailed summary of MSNs in the biomedical field, beginning with a comprehensive overview of their development history. We then discuss the types of MSNs-based nanostructured architectures, as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional components. Subsequently, we summarize the primary purposes of surface-functionalized modifications of MSNs. In the following, we discuss the biomedical applications of MSNs, and highlight the MSNs-based targeted therapeutic modalities currently developed. Given the importance of clinical translation, we also summarize the progress of MSNs in clinical trials. Finally, we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field.

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“…Moreover, unlike traditional antibiotics, which lead to several side effects, MSNs show a broad antimicrobial spectrum and are not easily prone to drug resistance [44]. These nanoparticles are now recognized as a desirable choice of antibiotics and potential alternatives for multi-drug resistance (MDR) microbial contamination [45,46].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Oxidized Mn-Ca Nanoparticles as Potential Antimicrobial Agents for Wound Healing

He,

Yuan,

et al. 2024

Molecules

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Managing chronic non-healing wounds presents a significant clinical challenge due to their frequent bacterial infections. Mesoporous silica-based materials possess robust wound-healing capabilities attributed to their renowned antimicrobial properties. The current study details the advancement of mesoporous silicon-loaded MnO and CaO molecules (HMn-Ca) against bacterial infections and chronic non-healing wounds. HMn-Ca was synthesized by reducing manganese chloride and calcium chloride by urotropine solution with mesoporous silicon as the template, thereby transforming the manganese and calcium ions on the framework of mesoporous silicon. The developed HMn-Ca was investigated using scanning electron microscopy (SEM), transmission electron microscope (TEM), ultraviolet-visible (UV-visible), and visible spectrophotometry, followed by the determination of Zeta potential. The production of reactive oxygen species (ROS) was determined by using the 3,3,5,5-tetramethylbenzidine (TMB) oxidation reaction. The wound healing effectiveness of the synthesized HMn-Ca is evaluated in a bacterial-infected mouse model. The loading of MnO and CaO inside mesoporous silicon enhanced the generation of ROS and the capacity of bacterial capture, subsequently decomposing the bacterial membrane, leading to the puncturing of the bacterial membrane, followed by cellular demise. As a result, treatment with HMn-Ca could improve the healing of the bacterial-infected wound, illustrating a straightforward yet potent method for engineering nanozymes tailored for antibacterial therapy.

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Silver Mesoporous Silica Nanoparticles: Fabrication to Combination Therapies for Cancer and Infection

Cited by 10 publications

References 110 publications

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Multifunctional mesoporous silica nanoparticles for biomedical applications

Mesoporous Oxidized Mn-Ca Nanoparticles as Potential Antimicrobial Agents for Wound Healing

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