Silver leaf nylon dressing to prevent radiation dermatitis in patients undergoing chemotherapy and external beam radiotherapy to the perineum

Vuong, T.; Franco, Eduardo L.; Lehnert, Shirley; Lambert, Christine; Portelance, Lorraine; Nasr, Elie; Faria, Sergio; Hay, John; Larsson, Stephan; Shenouda, George; Souhami, Luís; Wong, Frances; Freeman, Carolyn R.

doi:10.1016/j.ijrobp.2003.11.031

Cited by 49 publications

(30 citation statements)

References 44 publications

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“…Twenty-six of the preventive trials were rcts 2,16-25, 27-32,34-37, [41][42][43][44]46 , six were nonrandomized clinical trials 3,26,33,38,39,45 , and one was a retrospective trial 40 . Twenty-one of the trials were open 3,16,19,20,24-26, 28,29,32-35,37-43,45 , three were single-blind 17,22,27 , and nine were double-blind 2,18,21,23,30,31,36,44,46 .…”

Section: Resultsmentioning

confidence: 99%

“…Skin reactions were often assessed by one evaluator, which was commonly a radiation oncologist, dermatologist, research nurse, research assistant, radiation therapist, principal investigator, or other medical professional 3,17,20,21,24,26,27,32,33,35,39,44,46,50 . A few studies incorporated an inter-rater reliability measure by having more than one evaluator assess the skin reactions 23,34,36,45,49,51 ; the remaining studies did not describe who assessed the radiated area or areas 2,16,19,25,28,30,31,38,[41][42][43]47,48 .…”

Section: Resultsmentioning

confidence: 99%

“…Vuong et al 45 examined 15 patients receiving radiation to the perineum who were instructed to wear the dressing from the initiation of radiation until 2 weeks post radiation. Results were compared with data from historical controls.…”

Section: Dressingsmentioning

confidence: 99%

“…The evidence did not support the use of Aloe vera 22,23 or sucralfate cream 31,32 . There was some evidence to suggest that led treatment, pentoxifylline, silver-leaf dressings, washing with soap and water, and zinc supplements help to prevent radiation-induced skin reactions 3,17,[43][44][45] . A large multicentric rct comparing breast imrt with standard breast radiation treatment showed a significant reduction in moist desquamation in the imrt group.…”

Section: Prevention Of Acute Radiation-induced Skin Reactionsmentioning

confidence: 99%

“…The severity of the reaction is related to the dose per fraction, total dose delivered, use of bolus or other beam-modifying devices, size of the treatment field, site treated, use of concurrent chemotherapy or other agents, and individual susceptibility 8 . Areas of the body that contain skin folds, such as the groin, are at higher risk of developing a reaction because of a phenomenon called the "bolus effect"; these areas are more likely to receive a higher dose of radiation and more prone to bacterial contamination 9 . Prescribed treatment at low doses (<2000 cGy) in conventional fractionation at depth usually does not elicit a skin reaction, and consequently, patients receiving palliative treatment are not usually at risk 6 .…”

Section: Introductionmentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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Radiation therapy is a common treatment for cancer patients. One of the most common side effects of radiation is acute skin reaction (radiation dermatitis) that ranges from a mild rash to severe ulceration. Approximately 85% of patients treated with radiation therapy will experience a moderate-to-severe skin reaction. Acute radiation-induced skin reactions often lead to itching and pain, delays in treatment, and diminished aesthetic appearance-and subsequently to a decrease in quality of life.Surveys have demonstrated that a wide variety of topical, oral, and intravenous agents are used to prevent or to treat radiation-induced skin reactions. We conducted a literature review to identify trials that investigated products for the prophylaxis and management of acute radiation dermatitis. Thirty-nine studies met the pre-defined criteria, with thirty-three being categorized as prophylactic trials and six as management trials.For objective evaluation of skin reactions, the Radiation Therapy Oncology Group criteria and the U.S. National Cancer Institute Common Toxicity Criteria were the most commonly used tools (65% of the studies). Topical corticosteroid agents were found to significantly reduce the severity of skin reactions; however, the trials of corticosteroids evaluated various agents, and no clear indication about a preferred corticosteroid has emerged. Amifostine and oral enzymes were somewhat effective in preventing radiation-induced skin reactions in phase ii and phase iii trials respectively; further large randomized controlled trials should be undertaken to better investigate those products. Biafine cream (Ortho-McNeil Pharmaceuticals, Titusville, NJ, U.S.A.) was found not to be superior to standard regimes in the prevention of radiation-induced skin reactions (n = 6).In conclusion, the evidence is insufficient to support the use of a particular agent for the prevention and management of acute radiation-induced skin reactions. Future trials should focus on comparing agents and approaches that, in phase i and ii trials, suggest efficacy. These future phase iii randomized controlled trials must clearly distinguish between preventive and management strategies for radiation-induced dermatitis. Only then can evidence-based guidelines be developed, with the hope of standardizing the approach across centres and of improving the prevention and management of radiation-induced dermatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Dressingsmentioning

confidence: 99%

Section: Prevention Of Acute Radiation-induced Skin Reactionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles

Chen

et al. 2006

J of Applied Polymer Sci

206

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The poly(vinyl alcohol)/poly(N-vinyl pyrrolidone) (PVA-PVP) hydrogels containing silver nanoparticles were prepared by repeated freezing-thawing treatment. The silver content in the solid composition was in the range of 0.1-1.0 wt %, the silver particle size was from 20 to 100 nm, and the weight ratio of PVA to PVP was 70 : 30. The influence of silver nanoparticles on the properties of PVA-PVP matrix was investigated by differential scanning calorimeter, infrared spectroscopy and UV-vis spectroscopy, using PVA-PVP films containing silver particles as a model. The morphology of freeze-dried PVA-PVP hydrogel matrix and dispersion of the silver nanoparticles in the matrix was examined by scanning electron microscopy. It was found that a three-dimensional structure was formed during the process of freezing-thawing treatment and no serious aggregation of the silver nanoparticles occurred. Water absorption properties, release of silver ions from the hydrogels and the antibacterial effects of the hydrogels against Escherichia coli and Staphylococcus aureus were examined too. It was proved that the nanosilver-containing hydrogels had an excellent antibacterial ability.

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Preparation and characterization of crosslinked carboxymethyl chitosan–oxidized sodium alginate hydrogels

Fan

Pan

Zhou

et al. 2011

J of Applied Polymer Sci

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Oxidized sodium alginate (OSA) was prepared through an oxidation reaction of sodium alginate in the presence of sodium periodate. In situ crosslinked hydrogels were obtained through the crosslinking reaction between the active aldehyde of OSA and the amino of the carboxymethyl chitosan (CMCS). The effects of the addition of OSA on the structure and properties of the hydrogels are discussed. The structures of OSA, CMCS, and the hydrogels were analyzed by Fourier transform infrared spectroscopy, and the morphology of the hydrogels was characterized by X-ray diffraction and scanning electron microscopy. The results from the gelation time test show that the hydrogels had the shortest gelation time of 6.3 s when the addition of OSA was 8 mL. The results from the swelling degree determination test showed that the hydrogel swelling degree first increased and then decreased with the addition of OSA. With the introduction of nanosilver, the hydrogels showed a degree of antibacterial performance.

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Silver leaf nylon dressing to prevent radiation dermatitis in patients undergoing chemotherapy and external beam radiotherapy to the perineum

Cited by 49 publications

References 44 publications

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Preparation and antibacterial effects of PVA‐PVP hydrogels containing silver nanoparticles

Preparation and characterization of crosslinked carboxymethyl chitosan–oxidized sodium alginate hydrogels

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