Silver ion post-column derivatization electrospray ionization mass spectrometry for determination of tetrabromobisphenol A derivatives in water samples

Tian, Yong; Liu, Aifeng; Qu, Guangbo; Liu, Chunxiao; Chen, Jian; Handberg, Eric; Shi, Jianbo; Chen, Huanwen; Jiang, Guibin

doi:10.1039/c4ra16166a

Cited by 32 publications

(17 citation statements)

References 40 publications

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“…3). These methods offered an alternative analytical choice for detection of TBBPA derivatives, especially, as they cannot be ionized through commercially available ionization sources [47,48]. However, the introduction of large concentrations of AgNO3 could increase the possibility of instrument damnification.…”

Section: Mass Spectrometrymentioning

confidence: 99%

Recent advances in the analysis of TBBPA/TBBPS, TBBPA/TBBPS derivatives and their transformation products

Liu

et al. 2016

TrAC Trends in Analytical Chemistry

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Section: Mass Spectrometrymentioning

confidence: 99%

Recent advances in the analysis of TBBPA/TBBPS, TBBPA/TBBPS derivatives and their transformation products

Liu

et al. 2016

TrAC Trends in Analytical Chemistry

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“…The post‐column derivatization is an established approach for online labeling of compounds and, thereby, modification of their properties. Particular objectives are an increase in ionization efficiency and reduction of matrix interferences . In addition, a post‐column reaction can be utilized for the generation of diagnostic products.…”

Section: Introductionmentioning

confidence: 99%

Localization of double‐bond positions in lipids by tandem mass spectrometry succeeding high‐performance liquid chromatography with post‐column derivatization

Jeck

Korf

Vosse

et al. 2018

Rapid Comm Mass Spectrometry

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Rationale: Lipids are a group of biomolecules known for their importance in a broad variety of biological tasks, which is attributed to the diversity of their molecular structures.The exact position of the double bond in a lipid affects its biological properties. Therefore, the determination of its position is highly important. Nevertheless, the unambiguous assignment is still a challenging task and requires the development of new approaches. Methods: A novel method for pinpointing double-bond positions in lipids is presented based on the photochemical Paternὸ-Büchi reaction. Therefore, the reaction was performed using a post-column derivatization by ultraviolet (UV) light irradiation (254 nm) and an additional constant flow of acetone. The acetone adduct was formed due to the reaction of acetone with the double bond resulting in an oxetane. Subsequent fragmentation experiments generated diagnostic fragments allowing the localization of double-bond positions. Results: Intending online hyphenation with high-performance liquid chromatography (HPLC)/tandem mass spectrometry (MS/MS), the reaction was optimized regarding parameters such as reaction time and the influence of trace oxygen as well as solvents. An additional separation of the reaction products by means of HPLC enabled further characterization of the chemical structures formed by UV irradiation. To demonstrate the applicability of the developed method, a mixture of the constitutional phospholipid isomers bis(monooleoylglycero) phosphate and dioleoyl-phosphatidylglycerol was analyzed regarding their double-bond positions, and lipids from an extract of the green alga Chlamydomonas reinhardtii were investigated. Conclusions: The successful hyphenation of HPLC/MS/MS with the online reaction was demonstrated for localization of double bonds in single lipids, lipid mixtures, and complex biological samples. Matrix effects can be reduced and further structural information, for example in case of constitutional isomers, can be obtained. This opens up new avenues for pinpointing lipid double-bond positions even in complex samples.

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“…With derivatization with AgNO 3 , ESI-MS can trigger the TBBPA derivatives formed complexes ([MþAg]NO 3 ) online, which could be effectively electrosprayed to generate ionic clusters ([MþAg] þ ) for mass analysis. But Ag þ is necessary for this approach, and the introduction of large concentrations of AgNO 3 could increase instrument contamination (Tian et al, 2014(Tian et al, , 2015.…”

Section: Introductionmentioning

confidence: 99%

Sensitive immunoassay for simultaneous determination of tetrabromobisphenol A bis(2-hydroxyethyl) ether and tetrabromobisphenol A mono(hydroxyethyl) ether: An effective and reliable strategy to estimate the typical tetrabromobisphenol A derivative and byproduct in aquatic environments

Zhang

Zhu

Huang

et al. 2017

Environmental Pollution

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a b s t r a c tTetrabromobisphenol A bis(2-hydroxyethyl) ether (TBBPA DHEE), as one of the TBBPA derivatives, is frequently applied as a flame retardant. To date, however, little evidence has been gathered regarding its environmental behavior and fate. This is mainly attributed to the lack of an analytical approach available to measure it. Mass spectrometry cannot determine levels of TBBPA DHEE. LC-MS could not ionize TBBPA DHEE to yield enough fragments, while GC-MS could not be applied for the analysis either, due to the thermal degradation of TBBPA DHEE. We here designed a novel hapten, then conjugated it with a carrier protein and produced a type of polyclonal antibody capable of recognizing TBBPA DHEE. Based on this approach, a sensitive and high-throughput indirect competitive enzyme-linked immunosorbent assay (ELISA) was established. The respective detection limit (LOD, based on 90% B/B 0 ) and IC 50 calculated from the standard curve were 0.702 and 9.868 ng/mL for TBBPA DHEE. And the established method showed good tolerance to various matrix interferents. Using our ELISA, we measured the concentrations of these substances from environmental water samples with no pretreatment other than filtration. We found the presence of TBBPA DHEE in environmental water samples collected in Jiangsu province, and the detected concentrations ranging from 1.5 to 7.7 ng/mL. Our proposed method here could be applied to completely and systematically investigate TBBPA DHEE and TBBPA MHEE concentrations in environmental samples.

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Silver ion post-column derivatization electrospray ionization mass spectrometry for determination of tetrabromobisphenol A derivatives in water samples

Abstract: A rapid and sensitive method was developed for the identification and quantitation of tetrabromobisphenol

Cited by 32 publications

References 40 publications

Recent advances in the analysis of TBBPA/TBBPS, TBBPA/TBBPS derivatives and their transformation products

Recent advances in the analysis of TBBPA/TBBPS, TBBPA/TBBPS derivatives and their transformation products

Localization of double‐bond positions in lipids by tandem mass spectrometry succeeding high‐performance liquid chromatography with post‐column derivatization

Sensitive immunoassay for simultaneous determination of tetrabromobisphenol A bis(2-hydroxyethyl) ether and tetrabromobisphenol A mono(hydroxyethyl) ether: An effective and reliable strategy to estimate the typical tetrabromobisphenol A derivative and byproduct in aquatic environments

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