“…Although the zeta potential values measured by different research groups may be different from each other, the experimental data of various nanoparticles collected in Table 1 could still give some general trends, especially for the potential of binding with the biological moelcules. As shown in Table 1, the HA nanoparticles with different morphologies, 14 Ag@HA, 30 F-Cl@HA, 31 and Au/Ag@ HA, 35 had negative zeta potentials, some of which were found to be efficiently taken up by A375 cells and MG-63 cells. The HA particles with several kinds of oxygencontaining addtives, such as, citric acid@HA, 32 oxalic acid@HA 33 and malic acid@HA 34 also exhibited negative zeta potentials, whose values were dependent on the pH values (Table 1), Similar to HA nanoparticles, some other nanoparticles including Au/Ag nanoparticles, 35 cerium oxide nanoparticles 76 and iron oxide nanoparticles 29 with negative zeta potentials were able to effectively absorbed on MG-63, A549, and HeLa cells.…”