Silver(I) complexes of mono- and bidentate N-heterocyclic carbene ligands: Synthesis, crystal structures, and in vitro antibacterial and anticancer studies

Silver coordination compounds: A new horizon in medicine

“…Similar but less significant results were obtained in antiproliferative tests on the same colon tumor cell line with another silver binuclear complex based on an analogous para-xylyl linked bis-benzimidazole ligand (Fig.2, 9) [59] and with a series of benzimidazole-based Ag-NHC complexes (Fig. 2, 10 a-b) [60].…”

“…The precursor benzimidazolium salts had no activity against the same strains of bacteria, even at higher concentrations compared to the relative complexes. This difference in efficacy was interpreted as being due to an increase of lipophilicity upon silver coordination [49]. The same complexes were tested for anticancer activity in HCT116 and HT29 cell lines, with the binuclear and the symmetrically substituted Ag complex recording many fold higher activity compared with the standard.…”

Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity

“…Ag + in low concentrations is non-toxic to humans, therefore a compound that releases Ag + to the environment in a steady rate make an effective antimicrobial agent [2][3][4][5][6][7][8][9][10] . The effectiveness of a silver complex as an antimicrobial agent depends on the bioavailability of Ag + when the compound is solubilised.…”

“…From investigations to date, many groups of researchers have synthesised and determined the biological activity of a broad range of Ag-NHC complexes [10][11][12] . Specifically, compounds derived from benzimidazole-based NHC ligands have shown promising antimicrobial activity 9,11,[13][14][15][16][17][18][19][20] and various studies have extended their research to anticancer activity 6,9,13,14 .…”

Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex

“…Many metal complexes with transition metals as center ions show excellent antibacterial and antitumor activities, such as Cu(II) [1][2][3], Zn(II) [4][5][6], Mn(II) [7][8][9], Ni(II) [10][11][12], Ag(I) [13][14][15], and so on. Meanwhile, hydrazone compounds also exhibit good biological activities and are a kind of good ligand [16][17][18].…”