Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity

Abstract

This study reports the synthesis, characterisation and antimicrobial activity of five novel silver N-heterocyclic carbene (Ag-NHC) complexes obtained by N-propylphthalimide and N-methyldioxane substituted benzimidazolium salts with silver oxide. The reactions were performed at room temperature for 24 h in the absence of light. The obtained complexes were identified and characterised by 1 H and 13 C NMR, FT-IR and elemental analysis techniques. The minimum inhibitory concentration (MIC) of the complexes was determined for E. coli, P. aeruginosa, E. faecalis, S. aureus, C. tropicalis and C. albicans in vitro through agar and broth dilution. The results indicated that these complexes exhibit antimicrobial activity. In particular, complex 3 presented the significant broad spectrum antimicrobial activity.

Novel N‐propylphthalimide‐ and 4‐vinylbenzyl‐substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes

“…These ligands are known as unique ligands for the synthesis of industrial catalysts. On the other hand, in recent years, numerous studies have been carried out on the biological applications of NHC ligands and their metal complexes . In the last few decades, studies on antimicrobial and anticancer properties of NHC complexes containing metals such as Ag, Pd, Ru, Pt, and Au have been reported.…”

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

“…All the complexes exhibited MIC values in the range of 25-200 μg/mL but the standard drugs showed MIC values in the range of 0.39-3.12 μg/mL. [130]…”

“…None of the compounds showed better activity compared to standard drugs (ampicillin, Ciprofloxacin, and Fluconazole). All the complexes exhibited MIC values in the range of 25–200 μg/mL but the standard drugs showed MIC values in the range of 0.39–3.12 μg/mL [130] …”

Yeni Metal Komplekslerinin Sentezi ve Sitotoksik Aktivite Değerlendirmesi

“…They have broad ranges of biological activity applications. For example, some metal complexes including zinc, cadmium, cobalt, palladium, silver or mercury have antimicrobial (Dorosti et al, 2019;İlkimen et al, 2016;Mallela et al, 2018;Sarı et al, 2016), antifungal (Biswas et al, 2014;Ghazal et al, 2019;Yousef et al, 2016), antioxidant (Fetoh et al, 2018;Yousef et al, 2016), and anticancer (Akkoç, 2019a;Ali et al, 2019;Aslan et al, 2020;Bahron et al, 2019;Yaghobi et al, 2019) activities. Furthermore, these type compounds have also many different properties such as catalytic activity, porosity, magnetism and conductivity (Pettinari et al, 2012;Correa-Ayala et al, 2019;Gangu et al, 2019;Madhupriya et al, 2014;Akkoç et al, 2014).…”