Silver doped-silica nanoparticles reinforced poly (ethylene glycol) diacrylate/hyaluronic acid hydrogel dressings for synergistically accelerating bacterial-infected wound healing

Huang, Lin; Li, Wenqiang; Guo, Mingtao; Huang, Zhiguan; Chen, Yuhui; Dong, Xueping; Li, Yuhe; Zhu, Lin

doi:10.1016/j.carbpol.2022.120450

Cited by 26 publications

(15 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A hydrothermal method was used for the preparation of MSN. 25 As shown in Figure 1A,B, TEM was adopted to observe the morphology and particle size of the MSN. TEM showed that the MSN nanoparticles were spherical with clear and uniform dendritic mesopores and a uniform particle size.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Injectable and In Situ Formed Dual-Network Hydrogel Reinforced by Mesoporous Silica Nanoparticles and Loaded with BMP-4 for the Closure and Repair of Skull Defects

Zhan,

Yang,

Zhao

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

Bone defects are a common and challenging orthopedic problem with poor self-healing ability and long treatment cycles. The difficult-to-heal bone defects cause a significant burden of medical expenses on patients. Currently, biomaterials with mechanical stability, long-lasting action, and osteogenic activity are considered as a suitable way to effectively heal bone defects. Here, an injectable double network (DN) hydrogel prepared using physical and chemical cross-linking methods is designed. The first rigid network is constructed using methylpropenylated hyaluronic acid (HAMA), while the addition of chitosan oligosaccharide (COS) forms a second flexible network by physical cross-linking. The mesoporous silica nanoparticles (MSN) loaded with bone morphogenetic protein-4 (BMP-4) were embedded into DN hydrogel, which not only enhanced the mechanical stability of the hydrogel, but also slowly released BMP-4 to achieve long-term skull repair. The designed composite hydrogel showed an excellent compression property and deformation resistance. In vitro studies confirmed that the HAMA/COS/MSN@BMP-4 hydrogel had good biocompatibility and showed great potential in supporting proliferation and osteogenic differentiation of mouse embryo osteoblast precursor (MC3T3-E1) cells. Furthermore, in vivo studies confirmed that the DN hydrogel successfully filled and closed irregular skull defect wounds, effectively promoted bone regeneration, and significantly promoted bone repair compared with the control group. In addition, HAMA/COS/MSN@BMP-4 hydrogel precursor solution can quickly form hydrogel in situ at the wound by ultraviolet light, which can be applied to the closure and repair of wounds of different shapes, which provides the new way for the treatment of bone defects.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Adhesive strength was quantified with lap shear adhesion. 25 First, 0.1 mL of hydrogel precursor was dropped on one side of the glass sheet, covered with another glass sheet, and placed in the UV box for photocuring for 3 min. The adhesion strength was obtained by the shear force at breaking divided by the covered area.…”

Section: Adhesion Performancementioning

confidence: 99%

Injectable and In Situ Formed Dual-Network Hydrogel Reinforced by Mesoporous Silica Nanoparticles and Loaded with BMP-4 for the Closure and Repair of Skull Defects

Zhan,

Yang,

Zhao

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…10a). 79 This DN gel displayed improved compressive and tensile properties (Fig. 10b and c), as well as pH-responsive release of Ag, which has antibacterial properties.…”

Section: Hyaluronic Acid-based Dn Gelsmentioning

confidence: 93%

Recent advances in double network hydrogels based on naturally-derived polymers: synthesis, properties, and biological applications

Sinad,

Ebubechukwu,

Chu

2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Huang et al prepared the hydrogel PEGDA/C-HA-AMSN using polyethylene glycol diacrylate (PEGDA), catechol-modified hyaluronic acid (C-HA), and Ag-doped mesoporous silica nanoparticles (AMSN) (Figure 10C). 129 The AMSN framework is able to dissociate under acidic conditions, resulting in an acidresponsive release of Ag. Under neutral conditions, the drug release time of the hydrogel could only be maintained for 20 h, and the drug release amount was approximately 20%.…”

Section: Stimuli-responsive Adhesive Hydrogelsmentioning

confidence: 99%

Functional adhesive hydrogels for biological interfaces

Liu,

Peng,

et al. 2023

Smart Medicine

View full text Add to dashboard Cite

Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel adhesives is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive hydrogel without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments in the fabrication of functional adhesive hydrogels, which are suitable for a variety of application scenarios, particularly those that occur underwater or on tissue/organ surface conditions. The design strategies for a multifunctional adhesive hydrogel with desirable properties including underwater adhesion, self‐healing, good biocompatibility, electrical conductivity, and anti‐swelling are discussed comprehensively. We then discuss the challenges faced by adhesive hydrogels, as well as their potential applications in biological interfaces. Adhesive hydrogels are the star building blocks of bio‐interface materials for individualized healthcare and other bioengineering areas.

show abstract

Silver doped-silica nanoparticles reinforced poly (ethylene glycol) diacrylate/hyaluronic acid hydrogel dressings for synergistically accelerating bacterial-infected wound healing

Cited by 26 publications

References 49 publications

Injectable and In Situ Formed Dual-Network Hydrogel Reinforced by Mesoporous Silica Nanoparticles and Loaded with BMP-4 for the Closure and Repair of Skull Defects

Injectable and In Situ Formed Dual-Network Hydrogel Reinforced by Mesoporous Silica Nanoparticles and Loaded with BMP-4 for the Closure and Repair of Skull Defects

Recent advances in double network hydrogels based on naturally-derived polymers: synthesis, properties, and biological applications

Functional adhesive hydrogels for biological interfaces

Contact Info

Product

Resources

About