Silver-containing nanoparticles in the research of new antimicrobial agents against ESKAPE pathogens

Borthagaray, Graciela; Mondelli, Melina; Facchin, Gianella; Torre, Marı́a H.

doi:10.1016/b978-0-12-813661-4.00008-0

Cited by 9 publications

(5 citation statements)

References 236 publications

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“…Multiple strategies, such as monoclonal antibodies [which bind to the specific epitope of the bacterial cell targeting the conserved pathogenesis pathway and initiate immunological response leading to a second line of defense ( Chames et al., 2009 )], vaccines as a prophylactic tool to prevent the infection, and fecal microbiota transplant [one of the current trends where the stool from the healthy volunteer is transplanted into the patient helps in reversing the microbiome dysbiosis ( Leshem et al., 2019 )], are developed by tailoring specific drugs that target the rivals ( Woodworth et al., 2019 ; Bekeredjian-Ding, 2020 ; Zurawski and McLendon, 2020 ). Consigning all-rounders like metal nanoparticles augments the team’s strength by targeting multiple mechanisms simultaneously ( Borthagaray et al., 2018 ). There are multiple reports on the use of nanoparticles—metal, metal oxides, and polymeric—as a potential therapy to overcome the problem of resistance ( Sharmin et al., 2021 ).…”

Section: Alternate Strategies: a Way Of Escaping From Eskape Pathogensmentioning

confidence: 99%

Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Venkateswaran,

Vasudevan,

David

et al. 2023

Front. Cell. Infect. Microbiol.

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The human–bacterial association is long-known and well-established in terms of both augmentations of human health and attenuation. However, the growing incidents of nosocomial infections caused by the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) call for a much deeper understanding of these organisms. Adopting a holistic approach that includes the science of infection and the recent advancements in preventing and treating infections is imperative in designing novel intervention strategies against ESKAPE pathogens. In this regard, this review captures the ingenious strategies commissioned by these master players, which are teamed up against the defenses of the human team, that are equally, if not more, versatile and potent through an analogy. We have taken a basketball match as our analogy, dividing the human and bacterial species into two teams playing with the ball of health. Through this analogy, we make the concept of infectious biology more accessible.

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Section: Alternate Strategies: a Way Of Escaping From Eskape Pathogensmentioning

confidence: 99%

Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Venkateswaran,

Vasudevan,

David

et al. 2023

Front. Cell. Infect. Microbiol.

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“…The application of an electric field and the movement of nanoparticles (electrophoretic mobility) in a sample is measured by laser Doppler velocimetry as part of Zeta potential measurements. (Clogston and Patri, 2011;Borthagaray et al, 2018). The Zeta potential is used to study the interactions between colloids and electrolytes of the same or opposite charge (Rajpoot et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Bead milling liberates the antioxidant properties of nanosized tubers of Vernonia guineensis Benth (Asteraceae)

Eya'ane Meva,

Djomaha,

Nasim

et al. 2023

J. Bioresour. Environ. Sci.

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Vernonia guineensis Benth. (Asteraceae), locally known as ‘African ginseng’, is an herbaceous plant with various therapeutic properties, sold by herbalists, and used in several traditional African preparations. Nanosizing has the capability to potentiate those preparations in their pharmacological properties. Premilling and extensive grinding using a planetary ball mill were used to reduce the size of V. guineensis tubers towards antioxidant studies. Water was used as an environmental friendly, cost effective solvent and dispersant to generate a nanocolloidal suspension of V. guineensis tubers. Size and size distribution were determined via photon correlation spectroscopy at room temperature which allows discussion on stability by Zeta potential and polydispersity index. Phytochemical screening shows presence of alkaloids, coumarins, polyphenol, saponins, tanins, terpenes, and anthraquinones. The distribution curve in water shows a polydispersed system with large hydrodynamic particles of size close to 1000 nm and a Z-average of 484.5 nm. The preparation separate in two phases with polydispersity index 0.217 for the supernatant and 0.543 for the suspension. In the supernatant and suspension, the particles zeta potential were -12.3 mV and -13.7mV respectively. The Mastersizer analysis indicates that there are smaller particles in volume in the supernatant than in the suspension. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity shows an increase in antioxidant activity, compared to that of ascorbic acid, in the nanoformulated state. These findings allow us to conclude on the potential of size reduction when compared to solvent extraction in pharmacologic preparations.

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“…Some of the mechanisms of the antimicrobial mode of action of MNPs are summarized in Figure 1B. In the search for new antimicrobials to treat the ESKAPE pathogens, silver has been highlighted as a potential candidate to treat infectious diseases (Borthagaray et al, 2018). Silver nanoparticles (AgNPs) possess antimicrobial activity, and they act by disturbing cell membrane permeability, interacting with sulfur-and phosphorous-containing compounds including DNA, in addition to their ability to release silver ions, contributing to the antibacterial effect (Morones et al, 2005;Morones-Ramirez et al, 2013).…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

The Demand for New Antibiotics: Antimicrobial Peptides, Nanoparticles, and Combinatorial Therapies as Future Strategies in Antibacterial Agent Design

et al. 2020

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Silver-containing nanoparticles in the research of new antimicrobial agents against ESKAPE pathogens

Cited by 9 publications

References 236 publications

Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Bead milling liberates the antioxidant properties of nanosized tubers of Vernonia guineensis Benth (Asteraceae)

The Demand for New Antibiotics: Antimicrobial Peptides, Nanoparticles, and Combinatorial Therapies as Future Strategies in Antibacterial Agent Design

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