Silver-containing bioactive glasses for tissue engineering applications

Diba, Mani; Boccaccını, Aldo R.

doi:10.1533/9780857099051.2.177

Cited by 20 publications

(12 citation statements)

References 66 publications

(105 reference statements)

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“…Basically, there are three common ways to dope BGs: (i) by adding a compound during the glass‐melting route, (ii) by adding a compound during the sol‐gel synthesis process or (iii) by incorporating certain ions into the glass structure via an ion‐exchange process. Less common strategies include coatings on the glass structure or the compound as the disperse phase within glass matrices (Diba and Boccaccini ). Once incorporated, generally, the metal‐doped glass gradually dissolves (in aqueous medium) depending on its dissolution rate.…”

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

“…). These strategies have been used to synthesize Ag‐doped BGs (Diba and Boccaccini ). Ag 2 O‐doped BGs from sol‐gel or melt‐derived synthesis origin (Ag‐BGs) present bacteriostatic and bactericidal properties against various pathogen bacteria such as Escherichia coli , P. aeruginosa and S. aureus (Bellantone et al .…”

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

“…Although some reports have shown that BGs containing Ag (in different architectures) release Ag ions at a rate high enough to be bactericidal but not cytotoxic to bone cells (Catauro et al . ), the cytotoxicity of Ag is still a controversial issue (Mozafari and Moztarzadeh ; Diba and Boccaccini ). Nevertheless, other antibacterial doping agents, such as copper, have also been investigated (see below).…”

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

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Bioactive glasses as delivery systems for antimicrobial agents

Rivadeneira

Gorustovich

2017

J Appl Microbiol

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Summary Most biomaterial‐associated infections are caused by opportunistic pathogens and bacteria that are regularly found within the microflora of the implant site. In addition, a biomaterial implant or device remains at risk of infection by hematogenous spread of bacteria disseminated from infections elsewhere in the body or from infected peri‐implant tissue in revision surgery. The resulting infections are frequently accompanied by patient morbidity and discomfort and can lead to surgical replacement of the implant after lengthy, unsuccessful attempts to mitigate infections with antibiotic treatments. Therefore, extensive study is aiming to find new infection‐resistant antimicrobial biomaterials and coatings for implants and devices to effectively reduce the incidence of biomaterial‐associated infections. An overview of the in vitro and in vivo antimicrobial efficacies of the numerous biomaterials currently available is beyond the scope of this review. Herein, we provide a comprehensive review of bioactive glasses as biomaterial delivery systems for antimicrobial agents.

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Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

Section: Bioactive Glasses As Biomaterials Delivery Systems For Antimimentioning

confidence: 99%

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Bioactive glasses as delivery systems for antimicrobial agents

Rivadeneira

Gorustovich

2017

J Appl Microbiol

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“…The glasses and glass composites with AgNP can be prepared both with sol-gel and melt quenching methods by adding the Ag component [ 131 ] or can be introduced as AgNP in the structure of the composite [ 111 , 132 , 133 ]. The conventional melt quenching method applies silver nitrate (AgNO 3 ) or silver oxide (Ag 2 O) as the precursor.…”

Section: Metallic Nanoparticles In Composites With Bioactive Glassmentioning

confidence: 99%

Surface Plasmon Resonance or Biocompatibility—Key Properties for Determining the Applicability of Noble Metal Nanoparticles

et al. 2017

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Metal and in particular noble metal nanoparticles represent a very special class of materials which can be applied as prepared or as composite materials. In most of the cases, two main properties are exploited in a vast number of publications: biocompatibility and surface plasmon resonance (SPR). For instance, these two important properties are exploitable in plasmonic diagnostics, bioactive glasses/glass ceramics and catalysis. The most frequently applied noble metal nanoparticle that is universally applicable in all the previously mentioned research areas is gold, although in the case of bioactive glasses/glass ceramics, silver and copper nanoparticles are more frequently applied. The composite partners/supports/matrix/scaffolds for these nanoparticles can vary depending on the chosen application (biopolymers, semiconductor-based composites: TiO2, WO3, Bi2WO6, biomaterials: SiO2 or P2O5-based glasses and glass ceramics, polymers: polyvinyl alcohol (PVA), Gelatin, polyethylene glycol (PEG), polylactic acid (PLA), etc.). The scientific works on these materials’ applicability and the development of new approaches will be targeted in the present review, focusing in several cases on the functioning mechanism and on the role of the noble metal.

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“…One trend in the development of bioactive glasses is the incorporation of several ions able to enhance physical and therapeutic properties of the bioactive glasses [16], such as antibacterial activity (Ag [17,18], Ga [19,20]), stimulation of bone development and maintenance (Mg [21], Mn [22,23], Cu [24], Sr [25], Zn [26,27], Co [28]), fluorapatite precipitation (F [29,30]), mechanical properties (K [31]), reduction of local oxidative stress (Ce [32], Sr [33]) and magnetic local heater for tumours treatment (Fe [34]).…”

Section: Introductionmentioning

confidence: 99%

Composition and morphology effects on catalase mimetic activity of potential bioactive glasses

Malavasi

Lusvardi

2020

Ceramics International

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The catalase mimetic activity (CMA) of potential bioactive glasses based on Hench-45S5 Bioglass® (46.1%SiO 2-24.4%Na 2 O-26.9%CaO-2.6P 2 O 5 mol%, called H), Kokubo bioactive glass (50%SiO 2-25%Na 2 O-25%CaO mol%, called K) and mesoporous bioactive glass (80%SiO 2-15%CaO-5%P 2 O 5 mol%, called MBG) modified by the introduction of metal oxide (MO, M = Ti, V, Mn, Fe, Co, Cu, Zr and Ce) was tested in order to verify how their composition, morphology and synthesis procedure influence the ability to inhibit oxidative stress in terms of decomposition of hydrogen peroxide (H 2 O 2), a common reactive oxygen species (ROS). The characterization was achieved on the glasses before and after the soaking in H 2 O 2 in order to obtain information about the kinetic order, the rate and the type of mechanism related to the decomposition H 2 O 2 process. In fact, the H 2 O 2 decomposition can follow a radical mechanism (with the formation of OH% radical) or a peroxide-complex mechanism. Tests in SBF solutions were performed in order to verify the bioactivity in term of hydroxyapatite (HA) formation. The introduction of metal oxide into the glass composition promotes the CMA and the better catalytic activities were gained for the Co-, Mn-, Cu-, Ce-and Fe-containing glasses. All these glasses follow a 1st order kinetics but only in the case of Ce-containing glasses (H_4.0Ce) we observe a peroxide-complex mechanism. The Ce-containing glasses preserve their catalytic activity also coated with alginate and the reduction of glass powder dimension enhances the rate of H 2 O 2 decomposition. Mesoporous glasses with a high specific surface area show a higher H 2 O 2 decomposition rate with respect to that of melt-quenched derived glasses. The introduction of Ce, Cu, V, Ti, Zr and Fe do not modify the bioactivity in terms of HA formation during SBF tests (respect to H bioactive glass) and the alginate coating delay the HA formation without inhibiting its formation. H_5.3Co and H_5.3Mn showed the best catalytic performance (highest k value) but they seem not bioactive until 28 days of SBF soaking. By the data analysis obtained in this manuscript, we can affirm that the Ce-containing glasses are the most promising potential bioactive glasses with antioxidant properties.

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Silver-containing bioactive glasses for tissue engineering applications

Cited by 20 publications

References 66 publications

Bioactive glasses as delivery systems for antimicrobial agents

Bioactive glasses as delivery systems for antimicrobial agents

Surface Plasmon Resonance or Biocompatibility—Key Properties for Determining the Applicability of Noble Metal Nanoparticles

Composition and morphology effects on catalase mimetic activity of potential bioactive glasses

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