Silver complexes of ligands derived from adamantylamines: Water-soluble silver-donating compounds with antibacterial properties

Jimenez, Jorge; Chakraborty, Indranil; Rojas‐Andrade, Mauricio D.; Mascharak, Pradip K.

doi:10.1016/j.jinorgbio.2016.12.009

Cited by 43 publications

(26 citation statements)

References 34 publications

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“…In this regard, the Schiff bases and their metal complexes play an important role in the bioinorganic chemistry due to their structural diversity and wide spectrum of their biological activities. A number of copper and silver complexes with Schiff bases have been already studied for antibacterial activity [4][5][6][7][8][9][10][11][12][13][14]. Actually, there is not a drug that incorporates a copper in their structure, but is available only one product with silver, silver sulfadiazine (SSD).…”

Section: Introductionmentioning

confidence: 99%

Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Cifuentes-Vaca

Andrades-Lagos

Campanini-Salinas

et al. 2019

Inorganica Chimica Acta

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By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF 3 SO 3)(L)PPh 3 ] (1) or [ML 2 ]A (M = Ag, Cu; A = CF 3 SO 3 , ClO 4 or BF 4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL 2 ]ClO 4 (4) and [Ag(L)(PPh 3) 2 ](CF 3 SO 3) (6), which confirms the chelate nature of L and the presence of Ag•••H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes. Highlights 1. The synthesis of a new Schiff base with fluorene is described. 2. Coordination to silver and copper complexes has been carried out

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Section: Introductionmentioning

confidence: 99%

Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Cifuentes-Vaca

Andrades-Lagos

Campanini-Salinas

et al. 2019

Inorganica Chimica Acta

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“…In comparison with free L morph and the interesting reported silver complexes, coordination of L morph to Ag(I) improved the toxicity (MIC = 12.3 n m ) against S. aureus, P. aeruginosa, A. baumannii, C. albicans and C. neoformans giving rise to active species against bacteria resistant drugs. The free L morph and 2 showed superior antibacterial activity against E. coli and S. aureus, respectively, compared to silver sulfadiazine (MIC = 4, 8 and 8 µ m for E. coli, P. aeruginosa and S. aureus) . The toxicity cannot be simply discussed in terms of chelation, other factors such as size of the receptor sites, and diffusion, should be considered.…”

Section: Resultsmentioning

confidence: 99%

Structural Studies, Antimicrobial Activity and Protein Interaction of Photostable Terpyridine Silver(I) Complexes

Mansour

Radacki

2019

Eur J Inorg Chem

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Photostable mono-and binuclear silver(I) complexes derived from terpyridine ligands (4′-(2-pyridyl)-2,2′:6′,2′′-terpyridine (L PY ) (1), 4′-(4-phenyl morpholine)-2,2′:6′,2′′-terpyridine (L morph ) (2) and 1,4-bis (2,2′:6′,2′′-terpyridin-4′yl) benzene (L DB ) (3)) were synthesized and fully characterized in the solution and solid-state including [ 1 H-15 N] heteronuclear multiple bond coherence (HMBC) NMR analysis and single-crystal X-ray analysis of five-coordinates [Ag 2 (L PY ) 2 (CH 3 CN) 2 ](SO 3 CF 3 ) 2 . Based on the NMR and ESI-MS data, complex 1 exists as dimeric species, formed by head-to-tail interaction, while monomeric species [a]

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“…In light of this information, the antimicrobial activities of 1-4 were also tested against four gram-positive bacteria and five gram-negative bacteria. The experiments were conducted in triplicate to prevent possible errors, and SCF [Sulbactam (30 µg) + Cefoperazone (75 µg)] was used as a standard drug 53,92,93 . Results were 4 > 2 > 3 > SCF > 1 > KCN for antibacterial activities while for S. enteridis, and S. gallinarum were 4 > SCF > 1 > KCN sequence of antibacterial effects (Tables 4 and 5).…”

Section: Ihc Investigation Of Slides Treated By Ag(i) Molecules Immumentioning

confidence: 99%

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Karadağ

Korkmaz

Aydın

et al. 2020

Sci Rep

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Four new dicyanoargentate(I)-based complexes 1-4 were synthesized from certain metal ions with a tetradentate ligand [N, N-bis (2-hydroxyethyl)-ethylenediamine; N-bishydeten] and determined by diverse procedures (elemental, thermal, FT-IR, ESI-MS for 1-3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by [Cd(N-bishydeten) 2 ] 2+ cations and [Ag(CN) 2 ] − anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1-4) and anticancer effects (2-4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively. Despite the current advances in cancer therapy, the death rate from cancer and therapeutic agents are still increasing 1. A significant number of studies have focused on the synthesis and design of a new antiproliferative agent to reduce the risk of drug resistance and cell toxicity 2-4. Some of these studies are related to metallo compounds which constitute a significant part of agents with potent pharmacological activities, and their medicinal availability has been still explored 5,6. For example, some macrocyclic polyamines containing Ni, Cu, and Ru could recognize TAR RNA molecules and cleave them, and affect the interaction of Tat-RNA 7. Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells.

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Silver complexes of ligands derived from adamantylamines: Water-soluble silver-donating compounds with antibacterial properties

Cited by 43 publications

References 34 publications

Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Structural Studies, Antimicrobial Activity and Protein Interaction of Photostable Terpyridine Silver(I) Complexes

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

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