Silver-Coated Endotracheal Tubes Cleaned With a Mechanism for Secretion Removal

Pirrone, Massimiliano; Imber, David A.; Marrazzo, Francesco; Pinciroli, Riccardo; Bry, Lynn; Delaney, Mary L.; DuBois, Andrea M.; Thomas, John G.; Nistico, Laura; Melton-Kreft, Rachael; Bittner, Edward A.; Kacmarek, Robert M.

doi:10.4187/respcare.06222

Cited by 12 publications

(6 citation statements)

References 33 publications

(43 reference statements)

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“…Thus, it is logical to combine the 2 measures as in the study by Pirrone and colleagues. 16 As clearly acknowledged by the authors, the absence of a statistically significant impact of the combined intervention could be related to the small number of subjects studied. Another explanation could be the fact that only biofilm prevention was targeted in this study, and no specific measures were used to reduce microaspiration of gastric and oropharyngeal secretions.…”

Section: See the Original Study On Pagementioning

confidence: 93%

Improved Endotracheal Tubes for Prevention of Ventilator-Associated Pneumonia: Better Than Silver and Gold?

2018

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Section: See the Original Study On Pagementioning

confidence: 93%

Improved Endotracheal Tubes for Prevention of Ventilator-Associated Pneumonia: Better Than Silver and Gold?

2018

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“…84,86 The use of the mucus shaver might also prevent the loss of antimicrobial activity of tube coatings, as demonstrated by preclinical data; however, a recent small clinical trial conducted with a similar cleaning device failed to show any benefit. 87,88 In summary, current evidence support the use of an ETT cleaning device to preserve patency and possibly facilitate weaning by reduced airway resistance; a direct impact of VAP rate is still to be demonstrated.…”

Section: Ett Cleaningmentioning

confidence: 98%

Non-Pharmacological Interventions to Prevent Ventilator-Associated Pneumonia: A Literature Review

Coppadoro

Bellani

2019

Respir Care

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Ventilator-associated pneumonia (VAP) is a well-known complication of invasive mechanical ventilation in critically ill patients. The presence of an endotracheal tube (ETT) is one of the major culprits for VAP development: air flow moves pathogens toward the distal airways, while clearance of the trachea is blunted due to reduced tracheal ciliary movement and impaired cough. Several measures are recognized as being useful to prevent VAP, and these are usually grouped in a VAP bundle (ie, avoiding intubation or re-intubation whenever possible; head of bed elevation; hand hygiene; shortening ventilation through sedation interruptions, spontaneous breathing trials, or thromboembolic prophylaxis). However, other interventions have been proposed to reduce VAP rate; some of these interventions have been reported in large clinical trials to be effective, some have been evaluated in small observational studies, and still others at a pre-clinical stage. Some strategies aim to improve the ETT design via a subglottic drainage system, with treatment of the ETT surface to reduce pathogen activity, or by modification of the cuff shape or cuff material to provide a better seal. Another proposed strategy is improving airway care through control of cuff pressure, cleaning the ETT, or use of closed suction systems. Other interventions target a patient's position in the bed to reduce aspiration of digestive content in the airways, or the use of probiotics to modulate gastric flora. Some of these measures are supported by strong evidence, but the impact on relevant outcomes such as duration of ventilation or mortality, as well as cost-benefit ratio, is still unclear, resulting in lack of widespread use.

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“…Still, the regular removal of airway secretions did not reduce bacterial colonization of ETs compared to standard aspiration, nor did it reduce airway colonization. 57 …”

Section: Progress In Research On Antimicrobial Materials For Tracheal...mentioning

confidence: 99%

Antimicrobial Coating: Tracheal Tube Application

Chen¹,

Ling²,

Liu³

et al. 2022

IJN

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Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in mechanically ventilated patients, increasing mortality, prolonging the patient length of stay, and increasing costs. In recent years, extensive studies on ventilator-associated pneumonia have shown that tracheal intubation plays an essential role in the pathogenesis of VAP, with the primary mechanism being the rapid colonization of the tracheal intubation surface by microbiota. Antibiotics do not combat microbial airway colonization, and antimicrobial coating materials offer new ideas to solve this problem. This paper reviews the current research progress on the role of endotracheal tube (ET) biofilms in the pathogenesis of VAP and antimicrobial coating materials.

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Silver-Coated Endotracheal Tubes Cleaned With a Mechanism for Secretion Removal

Abstract: In 39 critically-ill subjects intubated with silver-coated ETTs, periodical cleaning maneuvers did not decrease bacterial colonization of the ETTs and did not lower respiratory tract colonization compared to the standard suctioning.

Cited by 12 publications

References 33 publications

Improved Endotracheal Tubes for Prevention of Ventilator-Associated Pneumonia: Better Than Silver and Gold?

Improved Endotracheal Tubes for Prevention of Ventilator-Associated Pneumonia: Better Than Silver and Gold?

Non-Pharmacological Interventions to Prevent Ventilator-Associated Pneumonia: A Literature Review

Antimicrobial Coating: Tracheal Tube Application

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