Silver carboxylate-doped titanium dioxide-polydimethylsiloxane coating decreases Cutibacterium acnes adherence and biofilm formation on polyether ether ketone

Silver Carboxylate as an Antibiotic-Independent Antimicrobial: A Review of Current Formulations, in vitro Efficacy, and Clinical Relevance

“…Preventing microbial adherence through compatibility with commonly used coatings and materials, such as implant materials, sutures, and surgical dressings, could also allow for a wider applicability of new antimicrobials. 19 – 23 Augmentation of penetration into areas where persister cells and biofilms thrive due to inaccessibility, such as pilosebaceous glands where pathogens like Cutibacterium acnes reside, would also enhance efficacy. 20 , 24 , 25 Lastly, as previously discussed, the ability of the antimicrobial agent to be effective against persister cells and biofilm formation, in addition to general antibiotic resistance, is key to addressing the growing problem.…”

“… 26 , 28 To address these concerns, silver carboxylate, a more novel formulation, has emerged as a likely safer and more efficacious alternative, especially as it potentially possesses several of the key novel antimicrobial traits mentioned previously. 20 , 22 , 23 , 29 – 32 Several studies on the formulation of silver matrices, antimicrobial activity, and cytotoxicity are currently being conducted to evaluate silver carboxylate as an effective clinical tool. 22 , 23 …”

“… 20 , 22 , 23 , 29 – 32 Several studies on the formulation of silver matrices, antimicrobial activity, and cytotoxicity are currently being conducted to evaluate silver carboxylate as an effective clinical tool. 22 , 23 …”

“…Silver also has significant potential for the treatment of multidrug-resistant (MDR) pathogens. A proprietary formulation of silver carboxylate (AgCar) that has undergone extensive validation 20 , 22 , 23 , 30 has emerged as a promising antimicrobial silver formulation due to a matrix chemistry that allows for a controlled and predictable loading and release of silver carboxylate. 29 – 31 This modification has been reported to result in an increase in duration of action, a decrease in toxicity and is a potential solution to maintaining longer bactericidal activity with an improved safety profile.…”

“…Recent work has investigated the efficacy of AgCar in a TiO 2 /PDMS matrix as an antimicrobial coating for commonly used orthopedic implant materials and prosthetic liners. 22 , 23 , 29 Tran et al (2013) initially investigated the cytotoxic effects of silver carboxylate in a titanium/siloxane coating on both in vitro osteoblasts and in vivo intramedullary nails in a goat model. For the in vitro experiments, osteoblast proliferation and viability were assessed using the WST-1 assay (Roche Applied Science, Indianapolis, IN, USA) and Staphylococcus aureus growth was assessed via optical density.…”