Silo-Filler's Disease

Douglas, W. W.; Hepper, Norman G.; Colby, Thomas V.

doi:10.1016/s0025-6196(12)65249-5

Cited by 97 publications

(45 citation statements)

References 30 publications

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“…Increased concentration and duration cause symptoms such as cyanosis, vomiting, vertigo, and a loss of consciousness. In individuals with more severe exposure, acute respiratory distress syndrome (ARDS), an acute lung injury pattern, laryngeal spasm, bronchiolar spasm, reflex respiratory arrest, or asphyxia, may develop, resulting in death [25].…”

Section: F Oxides Of Nitrogen (No X )mentioning

confidence: 99%

Acute Inhalation Injury

Görgüner

Akgün

2010

EAJM

104

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Inhaled substances may cause injury in pulmonary epithelium at various levels of respiratory tract, leading from simple symptoms to severe disease. Acute inhalation injury (AII) is not uncommon condition. There are certain high risk groups but AII may occur at various places including home or workplace. Environmental exposure is also possible. In addition to individual susceptibility, the characteristics of inhaled substances such as water solubility, size of substances and chemical properties may aff ect disease severity as well as its location. Although AII cases may recover in a few days but AII may cause long-term complications, even death.We aimed to discuss the eff ects of short-term exposures (minutes to hours) to toxic substances on the lungs.

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Section: F Oxides Of Nitrogen (No X )mentioning

confidence: 99%

Acute Inhalation Injury

Görgüner

Akgün

2010

EAJM

104

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“…En la Tabla 4 se describen las principales causas de bronquiolitis obliterante, destacando los casos asociados a enfermedades colágeno-vasculares (ej: artritis reumatoidea de larga evolución), exposición a gases irritantes, trasplantes de médula ósea y pulmón, drogas y colitis ulcerosa. A continuación, se describen las principales causas de bronquiolitis obliterante: d1) Bronquiolitis obliterante por inhalación de gases irritantes: Se produce infl amación severa y ulceración de la mucosa que ocasiona bronquiolitis constrictiva 15,[22][23][24] . El cuadro clínico suele ser de inicio agudo, de magnitud variable, con síntomas que afectan la vía aérea superior hasta cuadros de daño alveolar difuso o síndrome de distrés respiratorio agudo.…”

Section: D) Bronquiolitis Obliteranteunclassified

“…El cuadro clínico suele ser de inicio agudo, de magnitud variable, con síntomas que afectan la vía aérea superior hasta cuadros de daño alveolar difuso o síndrome de distrés respiratorio agudo. Luego de un período de latencia puede seguir un curso crónico, irreversible, caracterizado por tos, disnea y signos de obstrucción bronquial [22][23][24] . La distribución y extensión del daño bronquiolar dependen de la concentración del agente, duración de la exposición, solubilidad y reactividad biológica del agente y susceptibilidad individual.…”

Section: D) Bronquiolitis Obliteranteunclassified

Evaluación clínico-radiológica y clasificación de la bronquiolitis del adulto

et al. 2011

Rev. méd. Chile

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puc.cl L a enfermedad bronquiolar o bronquiolitis corresponde a un proceso inespecífi co, infl amatorio o fi brótico, de múltiples orígenes que involucra a los bronquiolos y alvéolos, se manifi esta por síntomas respiratorios inespecífi cos y compromiso funcional variable, que difi eren en su evolución, gravedad y pronóstico [1][2][3] . Desde el punto de vista anatómico, las diferentes entidades clínicas se manifi estan por cambios infl amatorios de magnitud variable y morfología distintiva centrados en la vía aérea pequeña, constituida por los bronquiolos menores de 2 mm de diámetro que no contienen tejido cartilaginoso de sostén en su pared 3-5 . La bronquiolitis puede presentarse en diversos escenarios clínicos, como enfermedad primaria (bronquiolitis obliterante, por exposición a polvos minerales o gases irritantes, infección viral, etc), como parte de una enfermedad intersticial (neumonitis por hipersensibilidad, bronquiolitis

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“…Constrictive bronchiolitis is a predictable consequence of the inhalation of many toxic fumes and gases which reach the small airways [46]. It has been most frequently described following nitrogen dioxide inhalation (silo-filler9s disease) [47]. Epithelial injury, notably to ciliated cells, is almost invariable following exposure to any oxidant gas or hot smoke, so that bronchiectasis readily seen on CT usually accompanies this type of obliterative bronchiolitis [48].…”

Section: Constrictive (Obliterative) Bronchiolitismentioning

confidence: 99%

Small airways diseases: detection and insights with computed tomography

Dm¹

2001

Eur Respir J

145

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Diseases affecting the small airways are difficult to detect by traditional diagnostic tests. Widespread involvement is needed before symptoms and abnormalities on pulmonary function testing or chest radiography become apparent. Obstruction of the bronchioles may be detected indirectly by computed tomography (CT) because regional under-ventilation results in reduced perfusion which in turn is shown as a mosaic attenuation pattern of the lung parenchyma. When there is inflammation of the bronchioles with accompanying exudate, the airways may become directly visible on CT, for example in cases of diffuse panbronchiolitis.Quantification of the various morphological features of small airways disease is possible from CT images and this increased precision has aided investigations of structure/function relationships.An understanding of the pathology and microscopic distribution of disease in relation to the airways allows some prediction of the likely computed tomography appearances in this wide spectrum of conditions, and thus helps to refine the differential diagnosis.

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Silo-Filler's Disease

Cited by 97 publications

References 30 publications

Acute Inhalation Injury

Acute Inhalation Injury

Evaluación clínico-radiológica y clasificación de la bronquiolitis del adulto

Small airways diseases: detection and insights with computed tomography

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