Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes

Dash, Rupesh; Mandal, Mahitosh; Ghosh, Sudip Kumar; Kundu, Subhas C.

doi:10.1007/s11010-008-9702-z

Cited by 136 publications

(104 citation statements)

References 29 publications

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“…Seo et al (2011) reported that the cholesterol and blood glucose lowering effect of silk was enhanced by increasing the sericin content. Dash et al (2008) reported that silk sericin from the tasar silkworm inhibits ultraviolet B (UVB)-induced apoptosis in human skin keratinocytes. These findings indicate that silk sericin is an important biomaterial in the cosmetic, functional health food, and biomedical industries.…”

Section: Ftir Measurements and Determination Of The Crystallinity Indexmentioning

confidence: 99%

The Effect of Extraction Conditions and Film Side on the Molecular Conformation of Silk Sericin Film

Jo¹,

Bae²,

Um³

2013

International Journal of Industrial Entomology

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In this study, silk sericin films were prepared using different extraction methods, and the molecular conformation of sericin was examined using Fourier-transform infrared spectroscopy with attenuated total reflection geometry. Additionally, the effect of the film side (air-facing side or plate-facing side) on the molecular conformation of the sericin films was investigated. Interestingly, the molecular conformation of the sericin film depended on the film side. The molecular conformation of air-facing side of the sericin film was significantly influenced by extraction solution and time. The b-sheet crystallization and the crystallinity index of the sericin film markedly increased with an increase in the extraction time in hot water. The order of the crystallinity indices for the sericin films obtained with different extraction solutions was as follows: citric acid solution > urea solution >> hot water. In contrast, no remarkable differences were observed in the molecular conformation of the plate-facing side of the sericin film after extraction in hot water for different time periods. Urea and citric acid solution extractions showed remarkably higher crystallinity indices for sericin than those obtained after hot water extraction. However, no significant differences were observed in the crystallinity index of sericin between urea and citric acid solution extraction in plate-facing side of the film. IntroductionSilk is a naturally occurring material from silkworms and consists of fibroin and sericin. Silk has been used as a high quality textile material for a long time. Sericin is usually removed from silk through a degumming process that significantly improves the luster and touch feeling of silk fiber.

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Section: Ftir Measurements and Determination Of The Crystallinity Indexmentioning

confidence: 99%

The Effect of Extraction Conditions and Film Side on the Molecular Conformation of Silk Sericin Film

Jo¹,

Bae²,

Um³

2013

International Journal of Industrial Entomology

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“…Sericin-containing food relives constipation, suppresses development of colon tumors and bowel cancer [2]. Sericin inhibits lipid peroxidation in in vitro rat brain homogenate [3] and inhibits UV-induced apoptosis in human skin keratinocytes [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silk Silver Nanoparticles form Silkworm Cocoons and Their Antibacterial Activity on Methicillin Resistant Staphylococcus aureus (MRSA) and Escherichia coli

A¹,

Venkatappa²

2017

J Nanomed Nanotechnol

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“…Nagai et al (2009) revealed that sericin can promote wound healing. Dash et al (2008) reported that tasar silk sericin inhibits ultraviolet-B-induced apoptosis in human skin keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

Effect of centrifugation on the structure and properties of silk sericin

Park¹,

Um²

2016

International Journal of Industrial Entomology

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Recently, silk sericin has been studied extensively for biomedical and cosmetic applications because of its unique properties, including UV resistance and wound healing ability. For use in applications, sericin is fabricated in various forms including films and gels. However, the mechanical properties of sericin are too weak. In this basic study on improving the mechanical properties of sericin, a silk sericin aqueous solution was separated into two layers by centrifugation. The solution viscosity, molecular conformation, and mechanical properties of each separation layer of the sericin were examined. Sericin from the lower layer had a higher solution viscosity and film mechanical properties (strength and strain) than that from the upper layer, implying that sericin from the lower layer had a higher molecular weight than that from the upper layer. The molecular conformation of the sericin films varied depending on the casting solvent. In aqueous solution, the sericin film from the lower layer showed a b-sheet conformation, whereas that from the upper layer displayed a random coil conformation. All the sericin films showed a highly b-sheet-crystallized state when cast in formic acid, regardless of the separation layer.

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Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes

Cited by 136 publications

References 29 publications

The Effect of Extraction Conditions and Film Side on the Molecular Conformation of Silk Sericin Film

The Effect of Extraction Conditions and Film Side on the Molecular Conformation of Silk Sericin Film

Synthesis of Silk Silver Nanoparticles form Silkworm Cocoons and Their Antibacterial Activity on Methicillin Resistant Staphylococcus aureus (MRSA) and Escherichia coli

Effect of centrifugation on the structure and properties of silk sericin

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