Silk sericin microcapsules with hydroxyapatite shells: protection and modification of organic microcapsules by biomimetic mineralization

Li, Wenhua; Cai, Yurong; Zhong, Qiwei; Yang, Ying; Kundu, Subhas C.; Yao, Juming

doi:10.1039/c5tb02328a

Cited by 38 publications

(22 citation statements)

References 37 publications

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“…Sericin/CaP composites can be designed as microsystems with a good loading and release capability for bioactive molecules to be applied in TE or as an anti-tumor therapeutic system ( Table 1). The drug release potential of sericin/CaP microcapsules was studied in a paper by Li et al (2016), by incubating sericin microcapsules with a supersaturated calcium phosphate solution containing citric acid. The CaP shell protected the inner sericin structure, and consequently the stored bioactive molecules until a pH change occurs.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

et al. 2020

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Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its recovery after being associated with numerous biological properties such as antioxidant, antibacterial, anti-coagulation and regenerative activities. In the past years, sericin has also demonstrated to be suitable as a template for CaP mineralization. The present review focuses on the recent developments for the production of sericin/CaP composites, exploring their potential applications in bioengineering and opening new avenues in other research fields such as in the cosmetic, food and environmental sectors. In addition, this paper can also be useful as a guideline to design future research based on sericin/CaP biomaterials.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

et al. 2020

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“…Yue X et al prepared AgNPs using SS as a reducing agent [1]. SS is one of the pollutants in silk processing process [15,16], and large amounts of SS emissions cause great pollution [17]. Compared with silk, SS has poor mechanical properties but a high degradation rate.…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Behavior and Super-Antibacterial Properties of Cotton Fabrics Modified with a Sercin-NIPAAm-AgNPs Interpenetrating Polymer Network Hydrogel

et al. 2018

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Poly(N-isopropylacrylamide) (PNIPAAm), sericin (SS), and silver nitrate were combined to prepare an interpenetrating network (IPN) hydrogel having dual functions of temperature sensitivity and antibacterial properties. The structure and size of AgNPs in such an IPN hydrogel were characterized by the Fourier Transform Infrared spectrum (FT-IR), X-ray powder diffraction (XRD) and Transmission Electron Microscope (TEM), and the thermal properties of the IPN hydrogel were characterized by Differential Scanning Calorimetry (DSC). Based on XRD patterns, Ag+ was successfully reduced to Ag0 by SS. It was observed by TEM that the particle size of silver particles was lower than 100 nm. The glass transition temperature (Tg) of IPN hydrogel was better than that of the PNIPAAm/AgNPs hydrogels, and lower critical solution temperature (LCST) values of the IPN hydrogel were obtained by DSC i.e. 31 °C. The thermal stability of the IPN hydrogel was successfully determined by the TGA. This IPN hydrogel was then used to modify the cotton fabrics by the “impregnation” method using glutaraldehyde (GA) as the cross-linking agent. The structures and properties of IPN hydrogel modified cotton fabric were characterized by scanning electron microscopy (SEM), FT-IR, and the thermogravimetry analysis (TGA). The results show that NIPAAm was successfully polymerized into PNIPAAm, and that there were neglected new groups in the hydrogel IPN. The IPN hydrogel was then successfully grafted onto cotton fabrics. SEM observations showed that the IPN hydrogel formed a membrane structure between the fibers, and improved the compactness of the fibers. At the temperature close to LCST (≈31 °C), the entire system was easily able to absorb water molecules. However, the hydrophilicity tended to decrease when the temperature was higher or lower than the LCST. The antibacterial rates of the modified cotton fabric against S. aureus and E. coli were as high as 99%.

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“…Nonetheless, for BSA desorption induced by PSB buffer solutions, it may be postulated that there is competition to the membrane surface between BSA and phosphate ions. Both chitosan and sericin have good affinity to phosphate, and this may explain the favourable release of desorbed BSA from the membrane surface. More in‐depth mechanistic studies on the protein desorption are needed to have a better understanding of protein elutability.…”

Section: Resultsmentioning

confidence: 99%

Chitosan/sericin blend membranes for adsorption of bovine serum albumin

Feng

2017

Can J Chem Eng

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Chitosan/sericin blend membranes for adsorption of bovine serum albumin (BSA) were investigated. A preliminary screening test was carried out to identify a suitable chitosan/sericin blend ratio. The blend membrane with a chitosan/sericin mass ratio of 4:1 was found to have a maximum adsorption capacity (qm) of 25.3 g/m2, which is 45 % greater than the maximum adsorption capacity of the pure chitosan membrane. The adsorption‐desorption cycle studies showed that the chitosan/sericin blend affinity membrane could be reused, and over 80 % of the original adsorption capacity was retained after regeneration. Compared to other affinity membranes for BSA adsorption, the chitosan/sericin membrane exhibited a significantly high adsorption capacity with a comparable adsorption rate.

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Silk sericin microcapsules with hydroxyapatite shells: protection and modification of organic microcapsules by biomimetic mineralization

Abstract: Silk protein sericin based organic–inorganic hybrid microcapsules are fabricated by incubating sericin microcapsules with a supersaturated calcium phosphate solution containing citric acid.

Cited by 38 publications

References 37 publications

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

Thermosensitive Behavior and Super-Antibacterial Properties of Cotton Fabrics Modified with a Sercin-NIPAAm-AgNPs Interpenetrating Polymer Network Hydrogel

Chitosan/sericin blend membranes for adsorption of bovine serum albumin

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