Silk protein-based hydrogels: Promising advanced materials for biomedical applications

Kapoor, Sonia; Kundu, Subhas C.

doi:10.1016/j.actbio.2015.11.034

Cited by 393 publications

(256 citation statements)

References 203 publications

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“…Generally, silk can be extracted from the cocoons or silk glands of silkworms and is mainly composed of two classes of proteins as fibroinand sericin [196][197][198][199][200]. It shows the great potential for tissue engineering applications [201]. Mandal …”

Section: Silkmentioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

368

161

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Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed. GRAPHICAL ABSTRACTDownloaded by [University of Sussex Library] at 08:36 28 June 2016 2

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Section: Silkmentioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

368

161

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“…Silk is a natural occurring material, referring to protein fibres produced by several insects and spiders [25]. It is mainly Silk Fibroin that is being used to create hydrogels.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…The gelation time can be shortened with the aid of physical changes as lowering the pH [27], increasing the Temperature [28], sonication [29] or by adding chemical crosslinking agents [30]. Silk is a good material for bioprinting, as it has good mechanical stability [25,31], and has shown to allow cells to attach and proliferate [32]. Jose et al show that mechanical properties, such as viscosity, yield stress, and solubility can be modified with the addition of non-toxic polyols, creating more possibilities for use in printing [33].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Current developments in 3D bioprinting for tissue engineering

Cornelissen

Faulkner-Jones

Shu

2017

Current Opinion in Biomedical Engineering

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This version is available at https://strathprints.strath.ac.uk/61660/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTCurrent developments in 3D bioprinting for tissue engineering AbstractThe field of 3-dimensional (3D) bioprinting have enjoyed rapid development in the past few years for the applications in tissue engineering and regenerative medicine. In this review, we summarize the most updated developments in 3D bioprinting for the applications in the tissue engineering with a focus on the printable biomaterials used as bioinks. These developments include 1) novel printing regimes have been enabled by the use of fugitive inks for the creation of intricate structures e.g. vascularized tissue constructs; 2) mechanical strength of printed constructs can be enhanced by co-printing soft and hard biomaterials; 3) bioprinted in-vitro models for drug testing applications are closer to reality. We conclude that the research and application of new bioinks will remain the key highlights of the future developments in 3D bioprinting for tissue engineering.

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“…Innovative fibroin biomaterials, such as hydrogels, films, non-woven silk mats, porous silk sponges, screws, scaffolds and plates, are widely used in orthopedics, craniofacial surgery, dental applications, reconstruction of damaged vessels and nerves by injury or disease [8,[13][14][15][16]. Silk fibroin has been also investigated for many other biomedical applications, including osteoblast, hepatocyte and fibroblast cell support matrixes, as well as for ligament tissue engineering [17], urologic tissue engineering and functional tissue engineering of the corneal epithelium [18,19].…”

Section: Silk Fibre Proteinsmentioning

confidence: 99%

The Mulberry Silkworm—A New Source of Bioactive Proteins

Łochyńska¹

2015

JAST-A

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Abstract:Beyond the commonly known proteins built silk fibres-fibroin and sericin, there are almost 300 bioactive proteins in the silkworm haemolymph. The aim of this work was to present bioactive compounds obtained from the silk fibre and isolated from the body of this insect, which may be used in medical and pharmacological applications. The most important are bioactive proteins. However, the juvenile stages of mulberry silkworm possess other very valuable active substances.

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Silk protein-based hydrogels: Promising advanced materials for biomedical applications

Cited by 393 publications

References 203 publications

PVA-based hydrogels for tissue engineering: A review

PVA-based hydrogels for tissue engineering: A review

Current developments in 3D bioprinting for tissue engineering

The Mulberry Silkworm—A New Source of Bioactive Proteins

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