Silk fibroin/poly(vinyl alcohol) photocrosslinked hydrogels for delivery of macromolecular drugs

Kundu, Joydip; Poole-Warren, Laura A.; Martens, Penny J.; Kundu, Subhas C.

doi:10.1016/j.actbio.2012.01.004

Cited by 125 publications

(75 citation statements)

References 46 publications

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“…Hydrogels have received a considerable attention for use in tissue engineering scaffolds (with gelatin methacrylamide/PEG [72], silk fibroin/poly(vinyl alcohol) [73], silk fibroin/gelatin [74] or others [75]), cartilage tissue engineering (with poly (ethylene glycol)/agarose [76]), vascular tissue engineering (dextran/gelatin [77]). Mechanically enhanced properties (e.g., Young's moduli) rivaling those of natural load-bearing tissues was found in a poly (acrylic acid)/end-linked poly (ethylene glycol) crosslinked material [78].…”

Section: Examples Of Final Properties For Photochemically Produced Ipnsmentioning

confidence: 99%

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Fouassier

Lalevée

2014

Polymers

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Abstract:In this paper, we propose to review the ways to produce, through photopolymerization, interpenetrating polymer networks (IPN) based, e.g., on acrylate/epoxide or acrylate/vinylether blends and to outline the recent developments that allows a one-step procedure (concomitant radical/cationic polymerization), under air or in laminate, under various irradiation conditions (UV/visible/near IR; high/low intensity sources; monochromatic/polychromatic sources; household lamps/laser diodes/Light Emitting Diodes (LEDs)). The paper illustrates the encountered mechanisms and the polymerization profiles. A short survey on the available monomer systems and some brief examples of the attained final properties of the IPNs is also provided.

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Section: Examples Of Final Properties For Photochemically Produced Ipnsmentioning

confidence: 99%

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Fouassier

Lalevée

2014

Polymers

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“…41 The use of hydrogels in oral drug delivery has been investigated 42 for small molecules such as fluorescein (Schoener et al, 2011), 43 doxorubicin (Schoener et al, 2013), Rhodamine-B (Kim et al,44 2009), diltiazem hydrochloride (Frutos et al, 2010), and diclofenac 45 sodium (Yang et al, 2012), as well as proteins such as insulin 46 (5.8 kDa) (Wood et al, 2010), calcitonin (3.4 kDa) (Carr et al, 2010; (22 kDa) (Carr et al, 2010), interferon b (23 kDa) (Kamei et al,49 2009), and bovine serum albumin (69 kDa) (Kamei et al, 2009;Lin 50 et al, 2005). While hydrogels have been explored for delivering 51 payloads larger than 70 kDa, these studies have been limited to 52 non-pH responsive hydrogels in non-oral applications (Bertz et al,53 2013; Kidd et al, 2012;Kundu et al, 2012;Tokatlian et al, 2012). In 54 addition, most previously developed hydrogels are specific in the 55 size and type of drug they are able to efficiently load (Kamei et al,56 2009; Morishita et al, 2006Morishita et al, , 2002, requiring various modifications 57 for each different drug type (Hoare and Kohane, 2008;Liechty 58 et al, 2011;Schoener et al, 2013).…”

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confidence: 99%

pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules

Watkins

Chen

2015

International Journal of Pharmaceutics

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“…Scaffolds can be fabricated using either natural or synthetic materials [Babaeijandaghi et al, 2010;Steinstraesser et al, 2010]. In recent years, scaffolds produced from combinations of natural and synthetic materials have received increasing attention [Mandal et al, 2011;Kundu et al, 2012]. We previously combined sericin, poly(vinyl alcohol) (PVA), glycerin (as a plasticizer) and genipin (as a crosslinking agent) to fabricate scaffolds with good physical properties [Aramwit et al, 2010b;Siritientong et al, 2011].…”

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confidence: 99%

Accelerated Healing of Full-Thickness Wounds by Genipin-Crosslinked Silk Sericin/PVA Scaffolds

Aramwit

Siritienthong

Srichana

et al. 2013

Cells Tissues Organs

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Silk sericin has recently been studied for its advantageous biological properties, including its ability to promote wound healing. This study developed a delivery system to accelerate the healing of full-thickness wounds. Three-dimensional scaffolds were fabricated from poly(vinyl alcohol) (PVA), glycerin (as a plasticizer) and genipin (as a crosslinking agent), with or without sericin. The physical and biological properties of the genipin-crosslinked sericin/PVA scaffolds were investigated and compared with those of scaffolds without sericin. The genipin-crosslinked sericin/PVA scaffolds exhibited a higher compressive modulus and greater swelling in water than the scaffolds without sericin. Sericin also exhibited controlled release from the scaffolds. The genipin-crosslinked sericin/PVA scaffolds promoted the attachment and proliferation of L929 mouse fibroblasts. After application to full-thickness rat wounds, the wounds treated with genipin-crosslinked sericin/PVA scaffolds showed a significantly greater reduction in wound size, collagen formation and epithelialization compared with the control scaffolds without sericin but lower numbers of macrophages and multinucleated giant cells. These results indicate that the delivery of sericin from the novel genipin-crosslinked scaffolds efficiently healed the wound. Therefore, these genipin-crosslinked sericin/PVA scaffolds represent a promising candidate for the accelerated healing of full-thickness wounds.

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Silk fibroin/poly(vinyl alcohol) photocrosslinked hydrogels for delivery of macromolecular drugs

Cited by 125 publications

References 46 publications

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules

Accelerated Healing of Full-Thickness Wounds by Genipin-Crosslinked Silk Sericin/PVA Scaffolds

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