Silk fibroin/hydroxyapatite composites for bone tissue engineering

Farokhi, Mehdi; Mottaghitalab, Fatemeh; Samani, Saeed; Shokrgozar, Mohammad Ali; Kundu, Subhas C.; Reis, Rui L.; Fatahi, Yousef; Kaplan, David L.

doi:10.1016/j.biotechadv.2017.10.001

Cited by 328 publications

(186 citation statements)

References 232 publications

Supporting

Mentioning

185

Contrasting

Order By: Relevance

“…Many other studies have examined the performance of “biopolymer alloys” by blending silk with another biopolymer, such as tropoelastin, collagen, and fibronectin or have included inorganic ceramics (reviewed in ref. ) to generate new material systems with expanded function. One of the hallmarks of silk is its inherent ability to organize structures at the nanometer scale; these structures then assemble, grow, and ultimately produce macroscale constructs with defined function.…”

Section: Bioengineered Silksmentioning

confidence: 99%

The Biomedical Use of Silk: Past, Present, Future

Holland

Numata

Rnjak‐Kovacina

et al. 2018

Adv Healthcare Materials

548

490

View full text Add to dashboard Cite

Humans have long appreciated silk for its lustrous appeal and remarkable physical properties, yet as the mysteries of silk are unraveled, it becomes clear that this outstanding biopolymer is more than a high‐tech fiber. This progress report provides a critical but detailed insight into the biomedical use of silk. This journey begins with a historical perspective of silk and its uses, including the long‐standing desire to reverse engineer silk. Selected silk structure–function relationships are then examined to appreciate past and current silk challenges. From this, biocompatibility and biodegradation are reviewed with a specific focus of silk performance in humans. The current clinical uses of silk (e.g., sutures, surgical meshes, and fabrics) are discussed, as well as clinical trials (e.g., wound healing, tissue engineering) and emerging biomedical applications of silk across selected formats, such as silk solution, films, scaffolds, electrospun materials, hydrogels, and particles. The journey finishes with a look at the roadmap of next‐generation recombinant silks, especially the development pipeline of this new industry for clinical use.

show abstract

Section: Bioengineered Silksmentioning

confidence: 99%

The Biomedical Use of Silk: Past, Present, Future

Holland

Numata

Rnjak‐Kovacina

et al. 2018

Adv Healthcare Materials

548

490

View full text Add to dashboard Cite

show abstract

“…In a quest to mimic bone tissue, several studies have focused on the synthesis of CaP composites using synthetic polymers [polyglycolic acid (PGA), poly L-lactic acid (PLLA), polylactic-coglycolic acid (PLGA), and polycaprolactone (PCL)] (Rezwan et al, 2006;Lee and Yuk, 2007;Chen et al, 2014), natural polymers (alginate, chitosan, cellulose) (Pighinelli and Kucharska, 2013;Cardoso et al, 2014;Salama, 2019), proteins (collagen, fibrin, keratin, and silk fibroin) (Dias et al, 2010;Bleek and Taubert, 2013;Brown and Barker, 2014;Liu, 2015;Farokhi et al, 2018), or combinations of the foregoing (Chen et al, 2014). Synthetic polymers may induce local and systemic host reactions due to the release of chemicals and monomers from polymer degradation, while natural polymers may lead to products with different characteristics due to the differences in raw materials (Chen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Silk fibroin has been widely used and investigated for applications such as sutures (Saxena et al, 2014), artificial ligaments (Farè et al, 2013), tissue engineering constructs (Kasoju and Bora, 2012), and substrates for cell culture (Liu et al, 2012). Fibroin/CaP composites have been reported and are considered suitable for load bearing applications (Yan et al, 2013;Farokhi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

et al. 2020

View full text Add to dashboard Cite

Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its recovery after being associated with numerous biological properties such as antioxidant, antibacterial, anti-coagulation and regenerative activities. In the past years, sericin has also demonstrated to be suitable as a template for CaP mineralization. The present review focuses on the recent developments for the production of sericin/CaP composites, exploring their potential applications in bioengineering and opening new avenues in other research fields such as in the cosmetic, food and environmental sectors. In addition, this paper can also be useful as a guideline to design future research based on sericin/CaP biomaterials.

show abstract

“…Composites. Silk fibroin (SF) extracted from silkworm has recently received attention due to its unique biological behavior, biocompatibility, biodegradability, high water and oxygen uptake, low immunogenicity, and strong mechanical properties [104,105]. It can be transformed from the α-helix to the β-sheet by the silkworm.…”

Section: Research On the Electrospinning Of Silk Fibroinmentioning

confidence: 99%

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Fa-dong

Jia

et al. 2020

Journal of Nanomaterials

View full text Add to dashboard Cite

Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization, and applications. Information of those polymers together with their processing condition for electrospinning of ultrafine fibers has been summarized in the paper. The application of electrospun natural biopolymer fibers in wound dressings was specifically discussed. Other issues regarding the technology limitations, research challenges, and future trends are also discussed.

show abstract

Silk fibroin/hydroxyapatite composites for bone tissue engineering

Cited by 328 publications

References 232 publications

The Biomedical Use of Silk: Past, Present, Future

The Biomedical Use of Silk: Past, Present, Future

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Contact Info

Product

Resources

About