Silk fibroin-coated PLGA dimpled microspheres for retarded release of simvastatin

Qiao, Feng; Zhang, Junjiang; Wang, Jianghong; Du, Bo; Huang, Xiangyong; Pang, Liyun; Zhou, Zhimin

doi:10.1016/j.colsurfb.2017.06.038

Cited by 33 publications

(22 citation statements)

References 28 publications

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“…This means that the curcumin release from Curc-SFNs is not a pure diffusional (Fickian) mechanism but involves a relaxational or convection mechanism which is usually associated with a major state or phase change [ 79 ]. The same drug release mechanism was found in the literature for polymeric microspheres loaded with simvastatin with DLC values similar to those presented in this work [ 67 ] and for polymeric nanoparticles containing diazepam [ 81 ].…”

Section: Resultssupporting

confidence: 88%

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Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy

et al. 2018

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Curcumin, extracted from the rhizome of Curcuma longa, has been widely used in medicine for centuries due to its anti-inflammatory, anti-cancer, anti-oxidant and anti-microbial effects. However, its bioavailability during treatments is poor because of its low solubility in water, slow dissolution rate and rapid intestinal metabolism. For these reasons, improving the therapeutic efficiency of curcumin using nanocarriers (e.g., biopolymer nanoparticles) has been a research focus, to foster delivery of the curcumin inside cells due to their small size and large surface area. Silk fibroin from the Bombyx mori silkworm is a biopolymer characterized by its biocompatibility, biodegradability, amphiphilic chemistry, and excellent mechanical properties in various material formats. These features make silk fibroin nanoparticles useful vehicles for delivering therapeutic drugs, such as curcumin. Curcumin-loaded silk fibroin nanoparticles were synthesized using two procedures (physical adsorption and coprecipitation) more scalable than methods previously described using ionic liquids. The results showed that nanoparticle formulations were 155 to 170 nm in diameter with a zeta potential of approximately −45 mV. The curcumin-loaded silk fibroin nanoparticles obtained by both processing methods were cytotoxic to carcinogenic cells, while not decreasing viability of healthy cells. In the case of tumor cells, curcumin-loaded silk fibroin nanoparticles presented higher efficacy in cytotoxicity against neuroblastoma cells than hepatocarcinoma cells. In conclusion, curcumin-loaded silk fibroin nanoparticles constitute a biodegradable and biocompatible delivery system with the potential to treat tumors by local, long-term sustained drug delivery.

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Section: Resultssupporting

confidence: 88%

“…The release experiments were carried out in triplicate for every sample. Experimental data were fitted using four release kinetic models found in the literature (zero order, first order, Higuchi and Ritger–Peppas) [ 67 ] to know the release mechanism of curcumin from the Curc-SFNs in PBS.…”

Section: Methodsmentioning

confidence: 99%

Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy

et al. 2018

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“…One millilitre of fresh PBS 1x (pH = 7.4) was added to the Eppendorf vial, which was placed again in the shaker. These experiments were carried out in triplicate for every sample, and experimental data were fitted using four release kinetic models found in the literature (Zero order, First order, Ritger-Peppas and Higuchi) [30] in order to elucidate the release mechanism of NAR from the NAR-SFNs in PBS.…”

Section: Naringenin Release From Nar-sfnsmentioning

confidence: 99%

“…Based on a pseudo-steady-state approach, this equation establishes a direct proportionality between the amount of drug released and the square root of time. However, transport from swelling systems can often lead to release through a mechanism that does not match Higuchi or Fickian behaviour but follows an anomalous (non-Fickian) transport mechanism [45], and a more generic equation is required [30]. It was found that the NAR release profiles of NAR-SFNs made with different loading solutions best fit a first order equation.…”

Section: Naringenin Releasementioning

confidence: 99%

Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

et al. 2020

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Naringenin (NAR), a flavonoid present in a variety of fruits, vegetables and herbs, exhibits a wide range of pharmacological effects, including anticancer activity. Nevertheless, its application in cancer therapy is limited due to its low bioavailability at the tumour site because of its poor solubility in water and slow dissolution rate. To improve the therapeutic efficacy of NAR, emergent research is looking into using nanocarriers. Silk fibroin (SF), from the Bombyx mori silkworm, is a biocompatible and biodegradable polymer with excellent mechanical properties and an amphiphilic chemistry that make it a promising candidate as a controlled release drug system. The aim of this work is to synthesize naringenin-loaded silk fibroin nanoparticles (NAR-SFNs) by dissolving the SF in the ionic liquid 1-ethyl-3-methylimidazolium acetate, using high-power ultrasounds and rapid desolvation in methanol followed by the adsorption of NAR. The NAR-SFNs were characterized by dynamic light scattering, Fourier transform infrared spectroscopy and thermogravimetric analysis. The drug loading content and encapsulation efficiency were calculated. The drug release profile best fitted a first order equation. The cytotoxicity effects of free NAR, bare silk fibroin nanoparticles (SFNs) and NAR-SFNs were assessed on HeLa and EA.hy926 cells via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results demonstrated the higher in vitro anticancer potential of synthesized NAR-SFNs than that of free NAR in HeLa cancer cells.

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“…To solve the shortcomings of these materials, a series of composite materials were synthesised. Coating silk fibroin on PLGA microspheres by single emulsion-solvent evaporation method could form a dimpled surface structures, with increased roughness and surface area and decreased acid degradation products of PLGA, which finally cause aseptic inflammation 33. Cao et al prepared a composite hydrogel incorporating PLGA microspheres and 2-N,6-O-sulphated chitosan (26SCS), a synergetic factor of growth factors, to load and deliver the osteogenic BMP-2 and angiogenic VEGF165 in the required manner.…”

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confidence: 99%

Review of craniofacial regeneration in China

Zhang

Xie

et al. 2019

J of Oral Rehabilitation

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Craniofacial defect is frequently caused by inflammation, trauma, and tumour etc The damaged tissues cannot be fully reconstituting the integrated matrix and regenerate native surface due to the complexity of craniofacial tissues, although with good intrinsic healing capacity. Till now, many approaches, such as manufacturing prosthesis, have obtained limited results. Tissue engineering has been recognised as one of the most effective means to replace or repair damaged tissues, which aims at forming a new viable tissue for a medical purpose. Such approaches need scaffolds that support the attachment, growth and proliferation of cells. With the development of modern medicine, the research of biomaterials has undergone a process from bio-inert materials to bioactive or degradable materials. The first generation of biomaterials was bio-inert materials with high strength, which included the metallic materials, ceramic materials, and polymeric materials. Whereas second-generation biomaterials were designed to be either resorbable or bioactive, the new biomaterials converged the separate concepts of bioactive materials and resorbable materials. Ideally, the scaffold must be of good biocompatibility and suitable physical and mechanical properties, furthermore, the scaffold must possess three-dimensional and properly porous network to allow cell adhesion, and controlled rate of degradation to match new tissue growth in vitro and in vivo. 1,2 Besides, the mechanism of tissue repair is complex and involves several important bioactive factors, 3,4 which function as inductive signals to provide cells with sufficient stimulus to migrate into tissues or biomaterials. Utilisation of growth factors, peptides or small molecules that associated with a natural matrix or biomaterial carrier has been extensively studied. Tissue engineering also utilises living cells as engineering materials, and cells became available as engineering materials when Bodnar et al 5 discovered how to extend telomeres in 1998, producingimmortalised cell lines. Stem cells are self-renewing and multipotent, with unique capacity to regenerate

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Silk fibroin-coated PLGA dimpled microspheres for retarded release of simvastatin

Cited by 33 publications

References 28 publications

Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy

Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy

Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

Review of craniofacial regeneration in China

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