Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

Fuster, Marta G.; Carissimi, Guzmán; Montalbán, Mercedes G.; Víllora, Gloria

doi:10.3390/nano10040718

Cited by 59 publications

(68 citation statements)

References 47 publications

(69 reference statements)

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“…Recently, a new set of mitochondrial potassium channels was discovered in skin-derived cells: keratinocytes, dermal fibroblasts, and endothelial cells [25,35,40,53,111]. Naringenin, a plant-derived flavonoid, has been known for many years to have the potential to improve many health problems, such as cardiovascular, metabolic, neurological, and pulmonary disorders; and cancer [112,113]. Recently, the cardioprotective function of naringenin due to activation of the cardiac mitoBK Ca channel was shown [114].…”

Section: Cgs7184mentioning

confidence: 99%

Mitochondrial Potassium Channels as Druggable Targets

et al. 2020

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Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have cytoprotective effects in cardiac or neuronal tissue. It has also been shown that inhibition of the mitochondrial Kv1.3 channel may lead to cancer cell death. Hence, in this paper, we examine the concept of the druggability of mitochondrial potassium channels. To what extent are mitochondrial potassium channels an important, novel, and promising drug target in various organs and tissues? The druggability of mitochondrial potassium channels will be discussed within the context of channel molecular identity, the specificity of potassium channel openers and inhibitors, and the unique regulatory properties of mitochondrial potassium channels. Future prospects of the druggability concept of mitochondrial potassium channels will be evaluated in this paper.

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Section: Cgs7184mentioning

confidence: 99%

Mitochondrial Potassium Channels as Druggable Targets

et al. 2020

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“…SFN were prepared as described elsewhere [ 13 , 16 ]. The freeze-dried SFN were dispersed in Milli-Q water by ultrasonication probe to a final concentration of 20 mg/mL.…”

Section: Methodsmentioning

confidence: 99%

“…The use of nanoparticles as delivery systems may provide numerous benefits [ 2 , 3 , 4 ], including enhanced drug delivery to tumor cells [ 5 , 6 ], controlled release and improved biodistribution [ 7 ], all of which result in a reduction of drug side effects [ 8 , 9 ]. Among polymeric nanoparticles used as delivery systems, silk fibroin-based nanoparticles (SFN) from the silkworm Bombyx mori have shown promising results, partly due to their biodegradability, biocompatibility and nontoxicity [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Their ability to penetrate biological membranes and their high drug loading capacity mean that SFN can greatly improve therapeutic treatments [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…As a model drug, we used SFN loaded with naringenin (NAR), a natural flavonoid [ 38 , 39 ], which has recently demonstrated its good compatibility with silk fibroin [ 16 ]. NAR has received increasing attention in medicine due to its free-radical scavenging [ 40 ], anti-inflammatory [ 41 ] and anticancer properties [ 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Direct Quantification of Drug Loading Content in Polymeric Nanoparticles by Infrared Spectroscopy

et al. 2020

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Nanotechnology has enabled the development of novel therapeutic strategies such as targeted nanodrug delivery systems, control and stimulus-responsive release mechanisms, and the production of theranostic agents. As a prerequisite for the use of nanoparticles as drug delivery systems, the amount of loaded drug must be precisely quantified, a task for which two approaches are currently used. However, both approaches suffer from the inefficiencies of drug extraction and of the solid-liquid separation process, as well as from dilution errors. This work describes a new, reliable, and simple method for direct drug quantification in polymeric nanoparticles using attenuated total reflection Fourier transform infrared spectroscopy, which can be adapted for a wide variety of drug delivery systems. Silk fibroin nanoparticles and naringenin were used as model polymeric nanoparticle carrier and drug, respectively. The specificity, linearity, detection limit, precision, and accuracy of the spectroscopic approach were determined in order to validate the method. A good linear relation was observed within 0.00 to 7.89% of naringenin relative mass with an R2 of 0.973. The accuracy was determined by the spike and recovery method. The results showed an average 104% recovery. The limit of detection and limit of quantification of the drug loading content were determined to be 0.3 and 1.0%, respectively. The method’s robustness is demonstrated by the notable similarities between the calibrations carried out using two different equipment setups at two different institutions.

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“…Cervical cancer [145], glioblastoma, lung cancer [146], pancreatic cancer [147] Silk fibroin NP, naringenin loaded PCL NP, multi-walled carbon nanotubes, naringenin-loaded PLGA NP…”

Section: Naringeninmentioning

confidence: 99%

Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management

et al. 2020

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Nanotechnology is the science of nanoscale, which is the scale of nanometers or one billionth of a meter. Nanotechnology encompasses a broad range of technologies, materials, and manufacturing processes that are used to design and/or enhance many products, including medicinal products. This technology has achieved considerable progress in the oncology field in recent years. Most chemotherapeutic agents are not specific to the cancer cells they are intended to treat, and they can harm healthy cells, leading to numerous adverse effects. Due to this non-specific targeting, it is not feasible to administer high doses that may harm healthy cells. Moreover, low doses can cause cancer cells to acquire resistance, thus making them hard to kill. A solution that could potentially enhance drug targeting and delivery lies in understanding the complexity of nanotechnology. Engineering pharmaceutical and natural products into nano-products can enhance the diagnosis and treatment of cancer. Novel nano-formulations such as liposomes, polymeric micelles, dendrimers, quantum dots, nano-suspensions, and gold nanoparticles have been shown to enhance the delivery of drugs. Improved delivery of chemotherapeutic agents targets cancer cells rather than healthy cells, thereby preventing undesirable side effects and decreasing chemotherapeutic drug resistance. Nanotechnology has also revolutionized cancer diagnosis by using nanotechnology-based imaging contrast agents that can specifically target and therefore enhance tumor detection. In addition to the delivery of drugs, nanotechnology can be used to deliver nutraceuticals like phytochemicals that have multiple properties, such as antioxidant activity, that protect cells from oxidative damage and reduce the risk of cancer. There have been multiple advancements and implications for the use of nanotechnology to enhance the delivery of both pharmaceutical and nutraceutical products in cancer prevention, diagnosis, and treatment.

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Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles

Cited by 59 publications

References 47 publications

Mitochondrial Potassium Channels as Druggable Targets

Mitochondrial Potassium Channels as Druggable Targets

Direct Quantification of Drug Loading Content in Polymeric Nanoparticles by Infrared Spectroscopy

Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management

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