Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing

Pacheco, Murilo Santos; Kano, Gustavo Eiji; Paulo, Letícia de Almeida; Lopes, Patrícia Santos; Moraes, Mariana Agostini de

doi:10.1016/j.ijbiomac.2020.02.140

Cited by 49 publications

(31 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous examples of entrapment for efficiency and release of active agents from chitosan/alginate complex beads are reported for medical and pharmaceutical purposes [31,32] and food applications [33,34]. The rationale for multilayer systems of chitosan and alginate is to reach a synergic effect of each biopolymer, without losing their individual intrinsic properties [35,36].…”

Section: Introductionmentioning

confidence: 99%

Study on the Influence of Bio-Based Packaging System on Sodium Benzoate Release Kinetics

Conte

Lecce

Iannetti

et al. 2020

Foods

View full text Add to dashboard Cite

The influence of film structure on the release kinetics of sodium benzoate (SB) from polymeric films is addressed in this study. In particular, four film structures were investigated, two monolayer and two multilayer systems. In particular, in one case, the active substance was uniformly distributed into a chitosan-based matrix, and in the other one, it was previously incorporated into alginate beads before dispersion in the chitosan film, thus realizing two types of monolayer films; on the other hand, the same chitosan film with SB encapsulated in alginate beads was used as the inner layer of a multilayer system constituted by two side films of alginate. The two alginate-based layers were made with two different thicknesses, thus producing a total of two multilayer systems. The release of SB from the above-mentioned films in water was studied by means of a UV/VIS spectrophotometer at 227 nm. A first-order kinetics-type equation was used to quantitatively describe the release data. Results suggest that the film structure strongly affected the release kinetics. In fact, monolayer films showed single-stage release kinetics, whereas the two investigated multilayer systems showed two-stage release kinetics. Further, the presence of alginate beads strongly affected the SB release, thus suggesting the potential of encapsulation to control the release mechanism of active compounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Study on the Influence of Bio-Based Packaging System on Sodium Benzoate Release Kinetics

Conte

Lecce

Iannetti

et al. 2020

Foods

View full text Add to dashboard Cite

show abstract

“…Membrane dressing is a semipermeable biomaterial similar as thin film, except that membrane has a certain degree of water absorption capacity, and thus can be used on wounds with moderate exudate, such as superficial wounds, frictional wounds, scratching wounds, and skin donor sites [ 144 , 145 ]. Gharibi et al developed an aniline tetramer embedded polyurethane/siloxane membrane as intelligent wound dressing [ 146 ].…”

Section: D Conductive Biomaterials For Wound Healingmentioning

confidence: 99%

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

2021

View full text Add to dashboard Cite

Conductive biomaterials based on conductive polymers, carbon nanomaterials, or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity to human skin, good antioxidant and antibacterial activities, electrically controlled drug delivery, and photothermal effect. However, a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking. In this review, the design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized. The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies (electrotherapy, wound dressing, and wound assessment) were reviewed. The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound (infected wound and diabetic wound) and for wound monitoring is discussed in detail. The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.

show abstract

“…The suitable topographical types fabricated on biomaterials can be used to regulate cell expansion, direction differentiation, and migration [24,25]. Moreover, understanding the mechanism of cell surface topographical interaction is of great significance for scaffold design in nerve tissue engineering [26,27]. Many studies have shown that microtopography can promote the proliferation of adherent cells including most nerve cells.…”

Section: Topography Affects Cell Proliferation and Differentiationmentioning

confidence: 99%

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Liu

et al. 2021

Stem Cells International

View full text Add to dashboard Cite

The surface topographies of artificial implants including surface roughness, surface groove size and orientation, and surface pore size and distribution have a great influence on the adhesion, migration, proliferation, and differentiation of nerve cells in the nerve regeneration process. Optimizing the surface topographies of biomaterials can be a key strategy for achieving excellent cell performance in various applications such as nerve tissue engineering. In this review, we offer a comprehensive summary of the surface topographies of nerve implants and their effects on nerve cell behavior. This review also emphasizes the latest work progress of the layered structure of the natural extracellular matrix that can be imitated by the material surface topology. Finally, the future development of surface topographies on nerve regeneration was prospectively remarked.

show abstract

Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing

Cited by 49 publications

References 45 publications

Study on the Influence of Bio-Based Packaging System on Sodium Benzoate Release Kinetics

Study on the Influence of Bio-Based Packaging System on Sodium Benzoate Release Kinetics

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

Contact Info

Product

Resources

About