Silicone granuloma on the entry points of acupuncture, venepuncture and surgical needles

Yanagihara, Makoto; Fujii, Tomoki; Wakamatu, Nobuhiko; Ishizaki, Hiroshi; Takehara, Teruaki; Nawate, Kiyoshi

doi:10.1034/j.1600-0560.2000.027006301.x

Cited by 46 publications

(31 citation statements)

References 8 publications

(10 reference statements)

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“…It has been well established that silicone can lead to a foreign body granulomatous reaction in the skin with the first histopathologic cases reported in 1964 [2]. Herein, we present what is believed to be the third reported case of silicone granulomas secondary to silicone-coated acupuncture needles [3,4].…”

Section: Introductionmentioning

confidence: 81%

“…The first reported case was that of a 55-year-old Japanese female who developed silicone granulomas at entry points of acupuncture, venipuncture and skin biopsy sites. Silicone was confirmed to be the causative agent by analytical electron microscopy with an energydispersive X-ray detector [3]. In 2001 a second case was reported in a 59-year-old Caucasian female.…”

Section: Discussionmentioning

confidence: 98%

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Silicone Granulomas in the Setting of Acupuncture with Silicone-Coated Needles

J¹

2014

J Clin Investig Dermatol

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Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 98%

Silicone Granulomas in the Setting of Acupuncture with Silicone-Coated Needles

J¹

2014

J Clin Investig Dermatol

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“…11 Additionally, there have been reports of formation of silicone granulomata following the use of coated needles for injection and for acupuncture. 12,13 The photographic appearance of the needle in Plate 11 is misleading, as the silicone coating has been damaged by the electron beam during microscopy. This made it impossible for us to investigate the surface of these needles in our survey, but if there were any metallic scuff or lumps on a needle, silicone coating might be presumed to smooth these over and anchor them to the surface, preventing them from catching in the skin or muscle and causing pain, or from becoming dislodged in the patient's body.…”

Section: Resultsmentioning

confidence: 99%

Single-Use Acupuncture Needles: Scanning Electron-Microscopy of Needle-Tips

Hayhoe¹,

McCrossan

Smith

et al. 2002

Acupunct Med

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Unselected, disposable acupuncture needles from various manufacturers and retail suppliers were taken from a pool of donated and bought samples. Three needles of each type were prepared for electron-microscopy. The needle tips were inspected at two magnifications (x39.37 and x612.5): 52 electron-micrographs were taken of 31 individual needles from 11 different types. No needle-tip looked perfect and significant faults were seen in most; some appeared seriously deformed. The faults noted were: scratch marks along or across the needle, metallic scuff, lumps and irregularities in the needle surface, needle-tip stubbed or malformed, and needle point off-centre. An additional test made was to wipe a number of needles firmly on white paper tissue. Some left grey lines, and these were regarded as evidence of metallic or oily residue from the needle surface which could have been deposited in the patient. These unexpected findings, in a variety of popularly used needles from well-respected suppliers, suggest that most manufacturers need to reassess their quality control procedures.

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“…Injection materials for facial corrections include collagen, 35 hyaluronic acid, 36 polymethylmethacrylate, 29 silicone, 37 and PTFE. 38 Adverse reactions reported on these materials in aesthetic treatments 39 are roughly similar to those in urinary treatments, but allergic or hypersensitive problems matter much more in aesthetic treatments.…”

Section: Discussionmentioning

confidence: 99%

Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results

2004

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Injection of bulking substances has been introduced as a new therapy to treat urinary incontinence and vesicoureteral reflux. Currently available bulking substances for the injection therapies include liquid or particulated silicone, collagen gel, and polytetrafluoroethylene paste. However, these materials have shown shortcomings such as inflammation, rapid volume decrease, and particle migration to distant organs. In the present study, we evaluated poly(lactic-co-glycolic acid) (PLGA) microspheres as a potential injectable bulking agent for the injection therapies. PLGA microspheres (52 m in average diameter) were injectable through various gauges of needles, as the injected microspheres showed no tendency to obstruct the needles and microsphere size exclusion was not observed upon injection through the needles. After injection of PLGA microspheres into the subcutaneous dorsum of mice, inflammation, new tissue volume change, and microsphere migration were examined. Host cells from the surrounding tissues migrated to the implanted microspheres and formed new hybrid tissue structures. The volume of the newly generated tissues was maintained approximately constant for 7 weeks. Histological analyses showed no evidence of migration of the implanted microspheres to the distant organs. In summary, PLGA microspheres were injectable and able to induce a new hybrid tissue formation without initial volume decrease or particle migration. These preliminary results suggest that this material may be a potentially useful bulking agent for urological injection therapies.

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Silicone granuloma on the entry points of acupuncture, venepuncture and surgical needles

Cited by 46 publications

References 8 publications

Silicone Granulomas in the Setting of Acupuncture with Silicone-Coated Needles

Silicone Granulomas in the Setting of Acupuncture with Silicone-Coated Needles

Single-Use Acupuncture Needles: Scanning Electron-Microscopy of Needle-Tips

Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results

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