Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection

He, Yao; Su, Shao; Xu, Tingting; Zhong, Yiling; Zapien, Juan Antonio; Jiang, Li; Fan, Chunhai; Lee, Shuit‐Tong

doi:10.1016/j.nantod.2011.02.004

Cited by 257 publications

(211 citation statements)

References 39 publications

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“…The Ag deposition on the GaAs surface was done by immersing the wafers in the aqueous solution of 0.4 mM AgNO 3 and 0.14 M HF at 25°C for 5, 20, and 35 s, respectively. According to previously reported of authors [15][16][17][18], we decided to use above concentration reagents and deposition time for AgNP high uniformity. Neither too sparse nor too dense, this condition chose to obtain the AgNP size diameter of range from 50 to 70 nm and *1 9 10 10 cm -2 of particle density, respectively.…”

Section: Methodsmentioning

confidence: 99%

Ag nanoparticle catalyst based on Ga2O3/GaAs semiconductor nanowire growth by VLS method

Nguyen

Kim

Dao

2015

J Mater Sci: Mater Electron

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In this paper, we report the synthesis results of Ga 2 O 3 semiconductor nanowires (NWs) on GaAs (100) semi-insulator substrate by vapor liquid solid (VLS) method. Our study based on Ag nanoparticle (AgNP) catalyst, in which prepared by conventional sol-gel method. As the GaAs wafer, after being deposited an AgNP layer in HF/AgNO 3 aqueous solution, which dried and loaded to vacuum-chamber. GaAs slices heated in vacuum-furnace by VLS method with two temperature modes. The results showed that the Ga 2 O 3 NW morphologies and properties depend strongly on technological conditions, such as AgNP catalyst concentration, growth temperature, and vapor pressure. It is also indicated that the NW random grown over large area with the diameter in the region conform from 18 to 30 nm scale and lengths ranging from several tens of nm to a few hundred micrometers.

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Section: Methodsmentioning

confidence: 99%

Ag nanoparticle catalyst based on Ga2O3/GaAs semiconductor nanowire growth by VLS method

Nguyen

Kim

Dao

2015

J Mater Sci: Mater Electron

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“…Fang and coworkers deposited metal ions on the top of SiNWs to fabricate a SERS sensor, which was suitable for detecting *600 molecules [100]. Very recently, He et al fabricated a sandwiched-structured SiNWsbased DNA SERS sensor, via serial immobilization of capture, target, and reported DNA, enabling ultrasensitive detection of DNA of a notably low concentration (0.1 fM) [93]. They further developed a new kind of silicon-based SERS biosensors by employing AgNPs-decorated silicon wafers (AgNPs@Si) as SERS substrates [110].…”

Section: Surface-enhanced Raman Scattering-based Biosensorsmentioning

confidence: 99%

Silicon-Based Platform for Biosensing Applications

He¹,

Su²

2014

SpringerBriefs in Molecular Science

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Development of high-performance biosensors vastly facilitates the analysis and detection of various biological species, including nucleic acids, protein, cell, etc. Functional nanomaterials (e.g., silver/gold nanoparticles, carbon nanotubes, graphene, silicon nanowires, etc) serve as new platform for design of nano-biosensors featuring high sensitivity and specificity. Taking advantage of the attractive merits of silicon nanowires (SiNWs) (e.g., unique electronic/optical properties, huge surface-to-volume rations, surface tailorability, fast response and good reproducibility, and compatibility with conventional silicon technology), SiNWs have been widely employed for constructing various kinds of electrochemical and optical biosensors, enabling ultrasensitive, specific, and reproducible detection of DNA and protein. We introduce a number of typical SiNWs-based biosensors (e.g., field-effect transistor (FET), amperometric-, surface-enhanced Raman scattering (SERS), and fluorescence-based biosensors) in this chapter, aiming to summarize the representative progresses of this research field in recent years. These kinds of high-quality silicon-based sensors show potentially great promise for myriad practical applications, such as medical diagnosis, food safety, drug security, environment monitoring, as well as anti-bioterrorism and so forth.Keywords Silicon nanowires Á Biosensor Á Field effect transistor Á Surfaceenhanced Raman scattering (SERS) Á DNA and protein detection Á Sensitivity and specificity Biological/chemical analysis and detection are of essential importance for disease diagnosis, drug discovery, food safety, environmental protection, and anti-bioterrorism, etc. While a large number of bioassay kits have been available on the market, there are ever-growing efforts to develop new detection methods with ultrahigh sensitivity and specificity, to meet the increasing demands of biosensing applications. Parallel to research efforts devoted to such high-end requirements, much recent interest has been directed toward the development of low-cost and portable biosensors, which possess comparable high sensitivity to conventional instruments, but with greatly reduced cost/mass/power requirements. Nanostructures (e.g., nanoparticles [1][2][3][4][5][6][7][8][9], nanotubes [10][11][12][13][14], and nanowires [15][16][17][18], etc) Y.

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“…On the other hand, in recent years, silicon nanostructures (such as NWs, nanopillars, and nanoparticles) have attracted more and more research interest because of their low-loss optical resonances in the visible region, which can give rise to strong light scattering [9,10]. Silicon nanostructures are therefore cultivated as promising SERS substrates [11,12]. Moreover, for practical device applications, the excellent semiconducting properties and compatibility with today's state-of-the-art CMOS techniques make silicon nanostructures superior to their metallic counterparts.…”

Section: Introductionmentioning

confidence: 99%

Superhydrophobic SERS substrates based on silicon hierarchical nanostructures

Chen

Wen

Zhou

et al. 2018

J. Opt.

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Silicon nanostructures have been cultivated as promising surface enhanced Raman scattering (SERS) substrates in terms of their low-loss optical resonance modes, facile functionalization, and compatibility with today's state-of-the-art CMOS techniques. However, unlike their plasmonic counterparts, the electromagnetic field enhancements induced by silicon nanostructures are relatively small, which restrict their SERS sensing limit to around 10 -7 M. To tackle this problem, we propose here a strategy for improving the SERS performance of silicon nanostructures by constructing silicon hierarchical nanostructures with a superhydrophobic surface. The hierarchical nanostructures are binary structures consisted of silicon nanowires (NWs) grown on micropyramids (MPs). After being modified with perfluorooctyltriethoxysilane (PFOT), the nanostructure surface shows a stable superhydrophobicity with a high contact angle of ∼160°. The substrate can allow for concentrating diluted analyte solutions into a specific area during the evaporation of the liquid droplet, whereby the analytes are aggregated into a small volume and can be easily detected by the silicon nanostructure SERS substrate. The analyte molecules (methylene blue: MB) enriched from an aqueous solution lower than 10 -8 M can be readily detected. Such a detection limit is ∼100-fold lower than the conventional SERS substrates made of silicon nanostructures. Additionally, the detection limit can be further improved by functionalizing gold nanoparticles onto silicon hierarchical nanostructures, whereby the superhydrophobic characteristics and plasmonic field enhancements can be combined synergistically to give a detection limit down to ∼10 -11 M. A gold nanoparticle-functionalized superhydrophobic substrate was employed to detect the spiked melamine in liquid milk. The results showed that the detection limit can be as low as 10 -5 M, highlighting the potential of the proposed superhydrophobic SERS substrate in practical food safety inspection applications.

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Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection

Cited by 257 publications

References 39 publications

Ag nanoparticle catalyst based on Ga2O3/GaAs semiconductor nanowire growth by VLS method

Ag nanoparticle catalyst based on Ga2O3/GaAs semiconductor nanowire growth by VLS method

Silicon-Based Platform for Biosensing Applications

Superhydrophobic SERS substrates based on silicon hierarchical nanostructures

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