Silicon 3D Microdetectors for Microdosimetry in Hadron Therapy

Guardiola, Consuelo; Fleta, C.; Quirion, D.; Pellegrini, G.; Gómez, F.

doi:10.3390/mi11121053

Cited by 17 publications

(17 citation statements)

References 50 publications

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“…Additionally, no differences in the spectra were found due to potential radiation damage when same measurements were repeated, although further studies are planned to determine the average life of these devices working under common particle accelerator intensities. Furthermore, with our 3D architecture, the capacitance is two orders of magnitude lower than a planar sensor of the same thickness 37 , which improves the overall signal-to-noise ratio.…”

Section: Discussionmentioning

confidence: 96%

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Microdosimetry Performance of The First Multi-Arrays of 3D-Cylindrical Microdetectors

Bachiller‐Perea

Zhang

Fleta

et al. 2021

Preprint

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Purpose: The present work reports on the microdosimetry measurements performed with the two first multi-arrays of microdosimeters with the highest radiation sensitive surface covered so far. The sensors are based on new silicon-based radiation detectors with a novel 3D cylindrical architecture. Methodology: Each system consists of arrays of independent microdetectors covering 2 mm×2 mm and 0.4 mm×12 cm radiation sensitive areas, the sensor distributions are arranged in layouts of 11×11 microdetectors and 3×3 multi-arrays, respectively. We have performed proton irradiations at several energies to compare the microdosimetry performance of the two systems, which have different spatial resolution and detection surface. The unit-cell of both arrays is a new type of 3D cylindrical diode with a 25 µm diameter and a 20 µm depth that results in a well-defined and isolated radiation sensitive micro-volume etched inside a silicon wafer. Measurements were carried out at the Accélérateur Linéaire et Tandem à Orsay (ALTO) facility by irradiating the two detection systems with monoenergetic proton beams from 6 to 18 MeV at clinical-equivalent fluence rates. Results: The microdosimetry quantities were obtained with a spatial resolution of 200 µm and 600 µm for the 11×11 system and for the 3×3 multi-array system, respectively. Experimental results were compared with Monte Carlo simulations and an overall good agreement was found. Conclusion: We have studied the microdosimetry response under clinical equivalent fluence rate of the first multi-arrays of 3D cylindrical microdetectors covering several centimeters of sensitive area. The good performance of both microdetector arrays demonstrates that this architecture and both configurations can be used clinically as microdosimeters for measuring the lineal energy distributions and, thus, for RBE optimization of hadron therapy treatments. Likewise, the results have shown that the devices can be also employed as a multipurpose device for beam monitoring in particle accelerators.

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Section: Discussionmentioning

confidence: 96%

“…Thickness values were carefully quantified during the manufacturing process with an optical method (reflectometry with NanoSpec 6100) and at the end of fabrication processes with the focused ion beam technique. More information about the fabrication process has been already reported in the literature 29,30,33,37 .…”

Section: Methodsmentioning

confidence: 99%

Microdosimetry Performance of The First Multi-Arrays of 3D-Cylindrical Microdetectors

Bachiller‐Perea

Zhang

Fleta

et al. 2021

Preprint

Self Cite

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Section: Methodsmentioning

confidence: 99%

Microdosimetry performance of the first multi-arrays of 3D-cylindrical microdetectors

Bachiller‐Perea

Zhang

Fleta

et al. 2022

Sci Rep

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The present work reports on the microdosimetry measurements performed with the two first multi-arrays of microdosimeters with the highest radiation sensitive surface covered so far. The sensors are based on new silicon-based radiation detectors with a novel 3D cylindrical architecture. Each system consists of arrays of independent microdetectors covering 2 mm$$\times$$ × 2 mm and 0.4 mm$$\times$$ × 12 cm radiation sensitive areas, the sensor distributions are arranged in layouts of 11$$\times$$ × 11 microdetectors and 3$$\times$$ × 3 multi-arrays, respectively. We have performed proton irradiations at several energies to compare the microdosimetry performance of the two systems, which have different spatial resolution and detection surface. The unitcell of both arrays is a 3D cylindrical diode with a 25 $$\mu$$ μ m diameter and a 20 $$\mu$$ μ m depth that results in a welldefined and isolated radiation sensitive micro-volume etched inside a silicon wafer. Measurements were carried out at the Accélérateur Linéaire et Tandem à Orsay (ALTO) facility by irradiating the two detection systems with monoenergetic proton beams from 6 to 20 MeV at clinical-equivalent fluence rates. The microdosimetry quantities were obtained with a spatial resolution of 200 $$\mu$$ μ m and 600 $$\mu$$ μ m for the 11$$\times$$ × 11 system and for the 3$$\times$$ × 3 multi-array system, respectively. Experimental results were compared with Monte Carlo simulations and an overall good agreement was found. The good performance of both microdetector arrays demonstrates that this architecture and both configurations can be used clinically as microdosimeters for measuring the lineal energy distributions and, thus, for RBE optimization of hadron therapy treatments. Likewise, the results have shown that the devices can be also employed as a multipurpose device for beam monitoring in particle accelerators.

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“…In practice, when it is mandatory to provide a dose verification in real time, the films are complemented with active radiation sensors as semiconductor or scintillation detectors, gas chambers, i.a. 19 – 22 .…”

Section: Introductionmentioning

confidence: 99%

Dosimetry with gafchromic films based on a new micro-opto-electro-mechanical system

Guardiola

Márquez

Jiménez-Ramos

et al. 2021

Sci Rep

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This work presents the first tests performed with radiochromic films and a new Micro‒Opto‒Electro-Mechanical system (MOEMS) for in situ dosimetry evaluation in radiotherapy in real time. We present a new device and methodology that overcomes the traditional limitation of time-delay in radiochromic film analysis by turning a passive detector into an active sensor. The proposed system consists mainly of an optical sensor based on light emitting diodes and photodetectors controlled by both customized electronic circuit and graphical user interface, which enables optical measurements directly. We show the first trials performed in a low‒energy proton cyclotron with this MOEMS by using gafchromic EBT3 films. Results show the feasibility of using this system for in situ dose evaluations. Further adaptation is ongoing to develop a full real‒time active detector by integrating MOEM multi‒arrays and films in flexible printed circuits. Hence, we point to improve the clinical application of radiochromic films with the aim to optimize radiotherapy treatment verifications.

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Silicon 3D Microdetectors for Microdosimetry in Hadron Therapy

Cited by 17 publications

References 50 publications

Microdosimetry Performance of The First Multi-Arrays of 3D-Cylindrical Microdetectors

Microdosimetry Performance of The First Multi-Arrays of 3D-Cylindrical Microdetectors

Microdosimetry performance of the first multi-arrays of 3D-cylindrical microdetectors

Dosimetry with gafchromic films based on a new micro-opto-electro-mechanical system

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