Siliceous‐based monolithic materials coated with a hydroxyapatite layer: Preparation and investigation of drug affinity by Raman spectroscopy

Abstract

Monolithic materials based on silica and hydroxyapatite was applied as tool for investigation of interactions between bone and potential antiresorptive drugs. First type of material was created on the basis of tetramethyl orthosilicate and trimethoxymethylsilane. Second type of material contained additionally chitosan in its structure. Ceramic fraction of monoliths was prepared in two ways: by incorporation of hydroxyapatite during crosslinking or by using soaking method (hydroxyapatite mineralization on the surface). Monolithic materials were prepared in two different forms: in the form of a cylinder and as a filling of a needle for monolithic in‐needle extraction (MINE) device. Several techniques were applied to evaluate the properties of 19 prepared materials: energy dispersive X‐ray spectroscopy, scanning electron microscopy, and Raman spectroscopy, which allowed to confirm and characterize occurred hydroxyapatite layer. Sorption–desorption investigation, with the sodium risedronate as test compound, was made with using ultraviolet‐visible spectroscopy, to assess the affinity of the bisphosphonate for the ceramic layer of the material as a bone substitute. One of 15 prepared MINE devices exhibits sorption ability of risedronate equal to 97%.

Carbon Fiber and Nickel Coated Carbon Fiber–Silica Aerogel Nanocomposite as Low-Frequency Microwave Absorbing Materials

“…Via the Raman spectra of pure silica aerogel, and as-prepared silica aerogel composites with carbon fibers, we can see the visible characteristic bands of silica. The Raman band at 973 cm −1 is related to Si-OH groups, the Raman band at around 800 cm −1 is attributed to the SiO2 network, and the broad band in the range from 200 cm −1 to 500 cm −1 is associated with Si-O-Si groups [38]. In the Raman spectra of AG and AG15%CF, besides the Raman bands of silica, visible Raman bands related to TMCS can be seen.…”

Recent advances in linear and nonlinear Raman spectroscopy. Part XIV

“…Their novel sensor that combines with SERRS and a pretreatment strategy, not only amplifies the Raman signal of norepinephrine but also paves the way for pretreating samples in complex systems. Zielinska et al [ 81 ] used siliceous‐based monolithic materials coated with a hydroxyapatite layer for preparation and measurement of drug affinity by Raman spectroscopy. Several techniques were applied to evaluate the properties of prepared materials, including energy dispersive X‐ray spectroscopy, SEM, and Raman spectroscopy, which allowed confirmation and characterization of the hydroxyapatite layer.…”