Silicate bioceramics induce angiogenesis during bone regeneration

In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO2–CaO–P2O5–Na2O system

“…In this regard, and given their great therapeutic potential, there is increasing interest in developing biomaterials that have inherent capacity to modulate the angiogenic activity. [17][18][19][20] Although a growing number of publications have reported the pro-angiogenic potential of bioceramic materials, such as bioactive glasses (BGs) and glass-ceramics and calcium phosphates, [21][22][23][24] the specic mechanisms that accelerate neovascularization in the presence of the ions released by the dissolution of BGs of different chemical compositions have not been elucidated.…”

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

“…Adding silicate ions into hydroxyapatite structure increases in vivo bioactivity and induces osteogenesis and angiogenesis during bone regeneration [20].…”

Cerium, gallium and zinc containing mesoporous bioactive glass coating deposited on titanium alloy

“…However, PCL lacks effective bond formation with bone in vivo [14,15]. On the other hand, mesoporous bioactive glasses possess ordered mesoporous channel structure, high textural properties (surface area, pore volume and pore size), ability to induce quick apatite-like layer formation to form bond with bone and excellent cytocompatibility [16,17]. Incorporating biologically beneficial elements such as cerium, gallium and zinc into glass matrix can further improve MBG.…”