Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review

Iafisco, Michele; Margiotta, Nicola

doi:10.1016/j.jinorgbio.2012.06.004

Cited by 58 publications

(38 citation statements)

References 107 publications

(115 reference statements)

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“…As a strong correlation exists between nano-scale dimension (< 100 nm) and cell responses [25], the concept of using nHA for biomedical applications to control cell fate in terms of proliferation and apoptosis is straightforward [26]. Moreover, bisphosphonates are renowned for their high affinity to HA [27]. Boanini A c c e p t e d M a n u s c r i p t osteoclast apoptosis [28].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

Bosco

Iafisco

Tampieri

et al. 2015

Applied Surface Science

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

Bosco

Iafisco

Tampieri

et al. 2015

Applied Surface Science

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“…18, 21, 24 Careful selection of organically modified precursors provides a route to control surface area, pore structure, and hydrophobicity. 25 These attributes allow for the release of NO (and other therapeutic agents) 26,27,28 from the xerogel network while simultaneously allowing diffusion of external species into the xerogel. Coupling the beneficial attributes of NO release with glucose sensor membranes has thus been proposed as a means for developing more functional sensors.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide-Releasing Xerogels Synthesized from N-Diazeniumdiolate-Modified Silane Precursors

Storm

2013

ACS Appl. Mater. Interfaces

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Nitric oxide (NO)-releasing xerogel materials were synthesized using N-diazeniumdiolate-modified silane monomers that were subsequently co-condensed with an alkoxysilane. The NO-release characteristics were tuned by varying the aminosilane structure and concentration. The resulting materials exhibited maximum NO release totals and durations ranging from 0.45–3.2 µmol cm−2 and 20–90 h, respectively. The stability of the xerogel networks was optimized by varying the alkoxysilane backbone identity, water to silane ratio, base catalyst concentration, reaction time, and drying conditions. The response of glucose biosensors prepared using the NO-releasing xerogel (15 mol% N-diazeniumdiolate-modified N-2-(aminoethyl)-aminopropyltrimethoxysilane) as an outer sensor membrane was linear (R2 = .979) up to 24 mM glucose. The sensitivity (3.4 nA mM−1) of the device to glucose was maintained for 7 d in phosphate buffered saline. The facile sol-gel synthetic route, along with the NO release and glucose biosensor characteristics, demonstrates the versatility of this method for biosensor membrane applications.

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“…Further fields of application concern local delivery of anti-cancer drugs. The functionalization of HA nanocrystals with platinum-bisphosphonate complexes to treat bone tumors has been successfully tested in vitro [123].…”

Section: Discussionmentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review

Cited by 58 publications

References 107 publications

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity

Nitric Oxide-Releasing Xerogels Synthesized from N-Diazeniumdiolate-Modified Silane Precursors

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

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