Silica nanoparticles as hepatotoxicants

Nishimori, Hikaru; Kondoh, Masuo; Isoda, Katsuhiro; Tsunoda, Shin-ichi; Tsutsumi, Yasuo; Yagi, Kiyohito

doi:10.1016/j.ejpb.2009.02.005

Cited by 209 publications

(129 citation statements)

References 29 publications

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“…However, a single intravenous injection of SiO 2 NPs resulted in their accumulation in the organs of the reticuloendothelial system, and caused the formation of multiple granulomas in the liver and spleen (Ivanov et al, 2012). Although some studies have demonstrated the complete biodegradation of SiO 2 NPs (Malvindi et al, 2012), most studies, in agreement with our data, reveal a delayed pattern of SiO 2 NP biodegradation (Nishimori et al, 2009;Xie et al, 2010). However, one cannot exclude the possibility that surface modification, including sulfonation, of SiO 2 NPs may affect the rate of their biodegradation.…”

Section: Introductionsupporting

confidence: 81%

Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity

et al. 2015

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Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of siliconcontaining NPs, including silica and organomodified silica NPs (SiO 2 NPs and OrSiO 2 NPs, respectively), with different surface modifications, with the aim of increasing drug-loading efficiency. In addition, we described the original synthesis methods of different sizes of OrSiO 2 NPs, as well as new hybrid OrSiO 2 NPs with a silica core (SiO 2 + OrSiO 2 NPs). Animal experiments revealed that the silicon-containing NPs investigated were non-toxic, as evidenced by a lack of hemodynamic response after intravenous administration. Bioelimination studies showed rapid renal excretion of OrSiO 2 NPs. In drug release kinetics studies, adenosine was immobilized on SiO 2 NPs using three different approaches: physical adsorption, ionic, and covalent bonding. We observed that the rate of adenosine desorption critically depended on the type of immobilization; therefore, adenosine release kinetics can be adjusted by SiO 2 NP surface modification technique. Adsorption of adenosine on SiO 2 + OrSiO 2 NPs resulted in a significant attenuation of adenosine-induced hypotension and bradycardia.

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Section: Introductionsupporting

confidence: 81%

Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity

et al. 2015

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“…As confocal microscope fi ndings showed that MNP@SiO 2 could enter the cell after treatment, irrespective of size, it may be owing to early cellular entry of MNP@SiO 2 . Base on recent reports that toxicity of silica nanoparticles was mediated through oxidant generation (Akhtar et al, 2010), and treatment of silica nanoparticles induced infl ammation (Hamilton et al, 2008) and enhanced infl ammatory cytokines (Nishimori et al, 2009), they could induce cellular toxicity even in larger size as well as small size.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and DNA Damage Induced by Magnetic Nanoparticle Silica in L5178Y Cell

Kang¹,

Yum²,

Park³

2011

Biomolecules and Therapeutics

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“…Nishimori et al (2009) tested nano-and micro-sized silica particles (70, 300, and 1000 nm) as potential toxicants in mice and reported that hepatic injury was only associated with 70 nm silica. Another study (Lankveld et al 2010) indicated organ-specific and size-dependent accumulation of silver nanoparticles after intravenous (iv) administration in rats.…”

Section: Introductionmentioning

confidence: 99%

Persistent Hepatic Structural Alterations Following Nanoceria Vascular Infusion in the Rat

Tseng

Lor

et al. 2013

Toxicol Pathol

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Understanding the long-term effects and possible toxicity of nanoceria, a widely utilized commercial metal oxide, is of particular importance as it is poised for development as a therapeutic agent based on its autocatalytic redox behavior. We show here evidence of acute and subacute adverse hepatic responses, after a single infusion of an aqueous dispersion of 85 mg/kg, 30 nm nanoceria into Sprague Dawley rats. Light and electron microscopic evidence of avid uptake of nanoceria by Kupffer cells was detected as early as 1 hr after infusion. Biopersistent nanoceria stimulated cluster of differentiation 3 þ lymphocyte proliferation that intermingled with nanoceria-containing Kupffer cells to form granulomata that were observed between days 30 and 90. Ultrastructural tracking of ceria nanoparticles revealed aggregated nanoceria in phagolysosomes. An increased formation of small nanoceria over time observed in the latter suggests possible dissolution and precipitation of nanoceria. However, the pathway for nanoceria metabolism/secretion remains unclear. Although frank hepatic necrosis was not observed, the retention of nanoceria increased hepatic apoptosis acutely, this persisted to day 90. These findings, together with our earlier reports of 5-nm ceria-induced liver toxicity, provide additional guidance for nanoceria development as a therapeutic agent and for its risk assessment.

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Silica nanoparticles as hepatotoxicants

Cited by 209 publications

References 29 publications

Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity

Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity

Cytotoxicity and DNA Damage Induced by Magnetic Nanoparticle Silica in L5178Y Cell

Persistent Hepatic Structural Alterations Following Nanoceria Vascular Infusion in the Rat

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