Silica Nanoparticles as a Basis for Efficacy of Antimicrobial Drugs

Лыков, А. П.; Гайдуль, К. В.; Гольдина, И. А.; Vi, Konenkov; Козлов, В. А.; Lyakhov, N. Z.; Душкин, А. В.

doi:10.1016/b978-0-323-46152-8.00025-1

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…Among the nanomaterials, special interest has been directed at silicon nanoparticles because of its excellent drug delivery capability. It is also biodegradable in nature, has reduced toxicity and stimulates macrophages [10]. Silica has been known as an abrasive agent used mostly in dentifrices, other functional versatility includes its use as a dentin blocking agent used for desensitization, teeth whitening, remineralization of teeth [11].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Mouthwash Incorporated with Silica Nanoparticles against S. aureus, S. mutans, E. faecalis: An in-vitro Study

Barma

Kannan

Indiran

et al. 2020

JPRI

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Silica based nanoparticles are used in various fields of medical sciences to diagnose, control disease, for genetic disorders, owing to their size, surface area, biocompatibility and low toxicity. In dentistry, silica nanoparticles have been used as dental filler, teeth whitening agent but limited evidence is there regarding antimicrobial activity against oral pathogens. Therefore, the current study was conducted to assess the anti-bacterial activity of mouthwash incorporated with silica nanoparticles against oral pathogens. Tetraethoxysilane, ammonium hydroxide, absolute ethanol were used and centrifuged to obtain the silica nanoparticle pellet. XRD analysis was done to confirm the characterization of the thus obtained silica nanoparticle. The mouthwash was prepared with the synthesized silica nanoparticle as the main constituent. Agar well diffusion method was used to assess the antimicrobial activity against S. mutans, S. aureus and E. faecalis. The XRD analysis confirmed the amorphous nature of the synthesized silica nanoparticles. The zone of inhibition was found to increase as the concentrations increased mainly for S. aureus and E. faecalis. The synthesized nanoparticles incorporated mouthwash showed good potential as antimicrobial agents against strains of gram positive bacteria. Further animal studies/in vivo research should be conducted to validate the above findings.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Mouthwash Incorporated with Silica Nanoparticles against S. aureus, S. mutans, E. faecalis: An in-vitro Study

Barma

Kannan

Indiran

et al. 2020

JPRI

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“…Silicon dioxide nanoparticles have been studied as drug carriers to enhance the antimicrobial activity of some drugs, because of their biodegradability, low toxicity, capacity to stimulate macrophages, and the ease by which they are synthetized and modified. The foremost advantage of these nanoparticles is that they can be loaded with large amounts of drug [95,175].…”

Section: Other Drug Delivery Systemsmentioning

confidence: 99%

“…Besides that, they present outstanding biocompatibility and chemical stability and can be degraded and metabolized over a relatively short term. These aspects allow high drug loading and reduce the probability of particle-induced toxicity [95,180].…”

Section: Other Drug Delivery Systemsmentioning

confidence: 99%

“…In a study, one group of mice with candidiasis induced by Candida albicans was treated with silica nanoparticles functionalized with amphotericin B and the other group was treated with officinal amphotericin B. It was possible to observe that the first group showed a significant increase in survival rates [ 95 ]. This confirms the fact that silica nanoparticles coated with quaternary ammonium surfactants have higher fungicidal and fungistatic effect against Candida albicans than colloidal silver [ 177 , 178 ].…”

Section: Nanotechnology and Mycologymentioning

confidence: 99%

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Current Insights on Antifungal Therapy: Novel Nanotechnology Approaches for Drug Delivery Systems and New Drugs from Natural Sources

et al. 2020

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The high incidence of fungal infections has become a worrisome public health issue, having been aggravated by an increase in host predisposition factors. Despite all the drugs available on the market to treat these diseases, their efficiency is questionable, and their side effects cannot be neglected. Bearing that in mind, it is of upmost importance to synthetize new and innovative carriers for these medicines not only to fight emerging fungal infections but also to avert the increase in drug-resistant strains. Although it has revealed to be a difficult job, new nano-based drug delivery systems and even new cellular targets and compounds with antifungal potential are now being investigated. This article will provide a summary of the state-of-the-art strategies that have been studied in order to improve antifungal therapy and reduce adverse effects of conventional drugs. The bidirectional relationship between Mycology and Nanotechnology will be also explained. Furthermore, the article will focus on new compounds from the marine environment which have a proven antifungal potential and may act as platforms to discover drug-like characteristics, highlighting the challenges of the translation of these natural compounds into the clinical pipeline.

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“…Over the last years, several studies have revealed that silica nanoparticles are excellent antimicrobial metal-releasing systems due to their high chemical and thermal stability and good biocompatibility [ 20 ]. The Si NPs enhance the bactericidal effects of some compounds, mainly metallic systems, against a broad range of microorganisms due to their easy delivery [ 20 , 140 ]. In addition, their surfaces can be easily modified by relatively inexpensive precursors which can increase their efficiency.…”

Section: Reviewmentioning

confidence: 99%

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Correa

Martínez

Vidal

et al. 2020

Beilstein J. Nanotechnol.

106

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The investigation of novel nanoparticles with antimicrobial activity has grown in recent years due to the increased incidence of nosocomial infections occurring during hospitalization and food poisoning derived from foodborne pathogens. Antimicrobial agents are necessary in various fields in which biological contamination occurs. For example, in food packaging they are used to control food contamination by microbes, in the medical field the microbial agents are important for reducing the risk of contamination in invasive and routine interventions, and in the textile industry, they can limit the growth of microorganisms due to sweat. The combination of nanotechnology with materials that have an intrinsic antimicrobial activity can result in the development of novel antimicrobial substances. Specifically, metal-based nanoparticles have attracted much interest due to their broad effectiveness against pathogenic microorganisms due to their high surface area and high reactivity. The aim of this review was to explore the state-of-the-art in metal-based nanoparticles, focusing on their synthesis methods, types, and their antimicrobial action. Different techniques used to synthesize metal-based nanoparticles were discussed, including chemical and physical methods and “green synthesis” methods that are free of chemical agents. Although the most studied nanoparticles with antimicrobial properties are metallic or metal-oxide nanoparticles, other types of nanoparticles, such as superparamagnetic iron-oxide nanoparticles and silica-releasing systems also exhibit antimicrobial properties. Finally, since the quantification and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review.

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Silica Nanoparticles as a Basis for Efficacy of Antimicrobial Drugs

Cited by 10 publications

References 31 publications

Antibacterial Activity of Mouthwash Incorporated with Silica Nanoparticles against S. aureus, S. mutans, E. faecalis: An in-vitro Study

Antibacterial Activity of Mouthwash Incorporated with Silica Nanoparticles against S. aureus, S. mutans, E. faecalis: An in-vitro Study

Current Insights on Antifungal Therapy: Novel Nanotechnology Approaches for Drug Delivery Systems and New Drugs from Natural Sources

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

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