Silica Nanoparticle Bioconjugates

Kotsuchibashi, Yohei; Ebara, Mitsuhiro; Narain, Ravin

doi:10.1002/9781118775882.ch12

Cited by 3 publications

(3 citation statements)

References 125 publications

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“…Fourth, the silica shell widens the applicability of the CS nanoassemblies. The silica coating not only provides stability to the particles in dispersion but also makes it easy to modify the surface with antibodies, DNAs, and other small molecules that may capture the sensing materials. , …”

Section: Resultsmentioning

confidence: 99%

“…The silica coating not only provides stability to the particles in dispersion but also makes it easy to modify the surface with antibodies, DNAs, and other small molecules that may capture the sensing materials. 22,52 Scalability and Purity. For practical applications of CS@ SiO 2 as a SERS probe, scalability or bulk production should be warranted.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Silica-Encapsulated Core–Satellite Gold Nanoparticle Assemblies as Stable, Sensitive, and Multiplex Surface-Enhanced Raman Scattering Probes

Trinh

Yoon

2022

ACS Appl. Nano Mater.

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Developing highly sensitive and stable surface-enhanced Raman scattering (SERS) probe systems is an actively pursued goal in sensors and diagnostics. In this study, we present silica-coated core–satellite (CS@SiO2) plasmonic nanoparticle assembly structures that potentially realize this goal. We assemble different-sized gold nanoparticles into core–satellite (CS) configurations using dithiol molecular linkers that also serve as SERS labels. Multiple hot spots in the CS structure and narrow nanogaps in each hot spot produce a significantly enhanced Raman scattering signal with an enhancement factor of ∼8 × 107. Various types of molecules can be inserted into the nanogaps using the mixed self-assembled monolayers with alkanedithiol, enabling multiplex detection. Silica encapsulation of the CS nanoassemblies stabilizes the particles and makes it easy to modify the surface to attach antibodies or DNAs. Many properties of the CS@SiO2, including a wide range of optical resonances, scalability using multiple glass slides, long-term stability in ethanol, and single-particle-level sensitivity, make the material an ideal SERS probe for sensitive and multiplexed detection of diseases and viruses.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Silica-Encapsulated Core–Satellite Gold Nanoparticle Assemblies as Stable, Sensitive, and Multiplex Surface-Enhanced Raman Scattering Probes

Trinh

Yoon

2022

ACS Appl. Nano Mater.

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show abstract

“…[57][58][59] Evidently, water is chosen as the major solvent and an alcohol (e.g. ethanol, [56][57][58] tert-butanol, 59 or 2propanol [60][61][62] ) is selected as the minor solvent. For example, Xu et al used a mixture of water/ethanol (75/25, v/v) for the RAFT dispersion polymerisation of NIPAM and functional comonomers (e.g.…”

Section: Introductionmentioning

confidence: 99%