Silica composite nanoparticles containing fluorescent solid core and mesoporous shell with different thickness as drug carrier

Ran, Zhipeng; Sun, Yong; Chang, Baisong; Ren, Qijun; Yang, Wuli

doi:10.1016/j.jcis.2013.08.015

Cited by 21 publications

(9 citation statements)

References 42 publications

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“…This approach could enhance the efficacy of the transporters and reduce the toxicity associated with chelation therapy. Compared to nonporous NPs, MSNs having large surface area and high porosity allow considerable loading of drugs . The diffusional release of therapeutics from the well‐ordered mesopores of MSNs is tunable and protects drugs from premature release as well as activates target area with biogenic local concentration, thereby reducing overall dose and preventing any acute or chronic complications …”

Section: Applications Of Msnsmentioning

confidence: 99%

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Mendiratta

Hussein

Nasser

et al. 2019

Part & Part Syst Charact

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that by 2040, neurodegenerative diseases will surpass cancer as the second reason of death after cardiovascular diseases in such aged populations. [1,2] As per a 2017 report, neurological diseases cost the United States of America about $800 billion annually and this number is expected to increase even further over the coming years as the percentage of aged citizens increases. [3] Unlike most other major diseases, the pace of drug development and delivery in case of neurodegenerative diseases has been stationary, partially due to lack of biomarkers that can diagnose such diseases long before the neurological symptoms arise and the challenges associated with identification of targets for drugs that can terminate or minimize neurodegeneration. Most importantly, delivering new cerebral therapeutic agents is impeded by the extensive and robust blood-brain barrier (BBB) which prevents the vast majority of drugs from crossing to the brain after systemic administration. During brain infections, intracerebral hemorrhage, or in neurodegenerative disorders, the BBB is altered in such a way that it allows easy access of inflammatory inducing molecules that may cause adverse neuronal damage. [4] Given the importance of early diagnosis and treatment of neurodegenerative diseases, new drug delivery technologies have appeared in the last decade.As shown in Scheme 1, unique nanomaterials have been reported and several nanosized drug delivery systems including liposomes, dendrimers, carbon nanotubes (CNTs), inorganic and hybrid nanoparticles, and polymeric micelles have gained attention and have been tested for targeted drug delivery not only for neurodegenerative diseases but also for several other ailments. [5][6][7][8][9][10] The discovery of MCM-41 was recognized as a major breakthrough in materials science and since then mesoporous silica nanoparticles (MSNs), thanks to their superior physiochemical properties such as large porosity, high surface areas, low toxicity, controllable sizes, and wide range of morphologies compared to conventional nanoparticles (NPs) have emerged as favorable tools in biomedical applications as nanocarriers for encapsulation and delivery of therapeutic medicines. [11][12][13][14] Designing biocompatible MSNs and their multifunctional derivatives for drug transport as well as theranostics is one of the hottest areas of research in the field of nanobiotechnology and nanomedicine. [15][16][17][18][19] High loading capacity, acceptable biocompatibility, and limitless possibilities of surface functionalization for specific cellular recognition Mesoporous silica nanoparticles (MSNs) have gained wide attention for their role in biomedicine and as drug delivery vehicles. Their structural tunability, high surface area, and easy functionalization impart significant advantages over conventional materials. In this Review, recent advances in the synthesis, drug delivery, and therapeutic roles of MSNs in the treatment of various neurodegenerative and neuroinflammatory diseases are presented. The intention is to...

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Section: Applications Of Msnsmentioning

confidence: 99%

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Mendiratta

Hussein

Nasser

et al. 2019

Part & Part Syst Charact

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“…The previous studies have shown that the shell thickness of HMSNs can be easily controlled by changing the amount of TEOS. 14,18,34 Therefore, we further investigate the effect of copolymer concentration on the size and morphology of HMSNs. Fig.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size using amphiphilic block copolymers as core templates

et al. 2014

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This paper presents a facile method for the fabrication of uniform hollow mesoporous silica nanoparticles (HMSNs) with tunable shell thickness and pore size. In this method, a series of amphiphilic block copolymers of polystyrene-b-poly (acrylic acid) (PS-b-PAA) with different hydrophobic block (PS) lengths were first synthesized via atom transfer radical polymerization (ATRP). The as-synthesized PS-b-PAA and cetyltrimethylammonium bromide (CTAB) were subsequently used as co-templates to fabricate HMSNs. This approach allows the control of shell thickness and pore size distribution of the synthesized HMSNs simply by changing the amounts of PS-b-PAA and CTAB, respectively. In vitro cytotoxicity and hemolysis assays demonstrated that the synthesized HMSNs had a low and shell thickness-dependent cytotoxicity and hemolytic activity. Therefore, these HMSNs have great potential for biomedical applications due to their good biocompatibility and ease of synthesis.

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“…The amorphous iron phase appears at this stage, making precipitation separation difficult. Seed induced crystallization can make crystals precipitate and crystallize from the solution at lower solution saturation, pH value and temperature, and has been widely used in the preparation and production of drugs and nanomaterials [26][27][28][29]. Han [30] choose natural limonite as the seed crystal of goethite and induce crystallization to improve the problem of poor filterability at the low pH goethite precipitate.…”

Section: Induced Crystallization Goethite Processmentioning

confidence: 99%

Magnetic Separation of Impurities from Hydrometallurgy Solutions and Waste Water Using Magnetic Iron Ore Seeding

Han¹,

Sun²,

Sun³

et al. 2021

Iron Ores

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The removal of iron ion from leaching solution is critical for the recovery of value metals, with the method of choice commonly being crystallization (precipitation). This paper summarized the new improvements in iron removal by precipitation methods in recent years and proposed a novel process, magnetic seeding and separation. The new process can promote iron precipitate aggregation and growth on the surface of the magnetic iron ore seeds. A core-shell structure was formed of iron precipitate and magnetic iron ore seeds, which can be magnetized and coalesced in magnetic field, accelerating the solid-liquid separation. The efficient magnetic flocculation and separation offset the poor settleability and filterability of the residues, contributing to the development of the hydrometallurgy process. Moreover, magnetic seeding and separation was also used for the removal of organic and inorganic contaminants from wastewater, significantly improving the purification efficiency. Therefore, iron ore not only played an important role in mining and steel manufacture, but also can be used to solve some problems in crossing fields.

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Silica composite nanoparticles containing fluorescent solid core and mesoporous shell with different thickness as drug carrier

Cited by 21 publications

References 42 publications

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size using amphiphilic block copolymers as core templates

Magnetic Separation of Impurities from Hydrometallurgy Solutions and Waste Water Using Magnetic Iron Ore Seeding

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