Silica-based systems for oral delivery of drugs, macromolecules and cells

Diab, Roudayna; Canilho, Nadia; Pavel, Ileana‐Alexandra; Haffner, Fernanda B.; Girardon, Maxime; Pasc, Andreea

doi:10.1016/j.cis.2017.04.005

Cited by 121 publications

(62 citation statements)

References 118 publications

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“…Mesoporous silica nanoparticles (MSNs), which have high porosity and specific surface area, tunable size, ideal biodegradability, and biosafety, were well accepted as a perfect drug delivery vehicle or system, therefore a promising vehicle for gene transfection. [24][25][26] Following the development of MSM-41-type MSN nano-vehicles for drug delivery in 2001, various types of MSNs have been designed on the basis of customized payloads that aim to deliver, e.g., bioactive molecules, plasmids, siRNA and DNA, and so on. [27][28][29][30] Advances have been made particularly in the application of MSNs as BTE scaffolds or at least a part of scaffolds in the recent years.…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of miR-26a on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by a Mesoporous Silica Nanoparticle - PEI - Peptide System</p>

Yan¹,

Lü²,

Zhu³

et al. 2020

IJN

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Introduction: RNA-based therapy for bone repair and regeneration is a highly safe and effective approach, which has been extensively investigated in recent years. However, the molecular stability of RNA agents still remains insufficient for clinical application. High porosity, tunable size, and ideal biodegradability and biosafety are a few of the characters of mesoporous silicon nanoparticles (MSNs) that render them a promising biomaterial carrier for RNA treatment. Materials and Methods: In this study, a novel miR-26a delivery system was constructed based on MSNs. Next, we assessed the miRNA protection of the delivery vehicles. Then, rat bone marrow mesenchymal stem cells (rBMSCs) were incubated with the vectors, and the transfection efficiency, cellular uptake, and effects on cell viability and osteogenic differentiation were evaluated. Results: The results demonstrated that the vectors protected miR-26a from degradation in vitro and delivered it into the cytoplasm. A relatively low concentration of the delivery systems significantly increased osteogenic differentiation of rBMSCs. Conclusion: The vectors constructed in our study provide new methods and strategies for the delivery of microRNAs in bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

<p>Effects of miR-26a on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by a Mesoporous Silica Nanoparticle - PEI - Peptide System</p>

Yan¹,

Lü²,

Zhu³

et al. 2020

IJN

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“…The encapsulation of rutin [14][15][16] and quercetin [17] was proposed as a way to obtain a product with protective effects against oxidative stress. Silica-based materials are suitable for oral delivery of drugs [18][19][20][21][22]. The advantage of silica is the simplicity of chemical modification due the presence of hydroxyl on the inner and outer surface of the material.…”

Section: Introductionmentioning

confidence: 99%

Hesperidin: synthesis and characterization of bioflavonoid complex

Binkowska

2020

SN Appl. Sci.

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Flavonoids are widely recognized for their beneficial effects in the cosmetic industry, possessing many biological activities, such as antioxidant, anti-inflammatory and antimicrobial properties. The study presented an efficient and simple solution to improve the preparations of antioxidant complexes based on hesperidin. Obtained products are characterized by thermogravimetric, spectrophotometric method, electron scanning microscopy, color analysis and zeta potential. Lightness value (L*) of hesperidin-silica complexes was found to be inversely correlated with the antioxidant activity values.

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“…Quartz is one of the most widely distributed minerals on the earth's surface. It is the main form of silica in the earth's crust (Diab et al, 2017). Because of optical, thermal and chemical durability, it is widely used in optical communication systems, foundry, ceramics, refractories, metallurgy, construction, and chemical industries as a heat-resistant glass and semiconductor materials (Cullinan et al, 2013).…”

Section: Activation Of Mapk and Cyclin D1/cdk4 In Malignant Transformmentioning

confidence: 99%

Activation of MAPK and Cyclin D1/CDK4 in Malignant Transformation of Human Embryonic Lung Fibroblasts Induced by Silica and Benzopyrene

Wang

Xiao²,

Tang

et al. 2020

Asian Pac J Cancer Prev

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Objective: Silica and Benzo(a)pyrene are listed as carcinogens. This study aims to explore Cyclin D1, CDK4 and difference of cell cycle adjusted by MAPK signal transduction pathway in silica and B(a)P-induced malignant transformation of human embryonic lung fibroblasts. Methods: Activity of the subfamily (ERK, p38 and JNK) of mitogen-activated protein kinase (MAPK), cyclin D1 and CDK4 (cyclin dependent kinase) were evaluated using Human embryonic lung fibroblast (HELF) purchased from the cell room, basic research institute, Chinese Academy of Medical Sciences. The expression of cyclin D1 and CDK4 (cyclin dependent kinase) were measured in silica and B(a) P induced malignant using Western blot (WB) assay. Results: PERK and P-JNK expression increased significantly (P<0.01), while CDK4 and P-p38 expression decreased (P<0.01, P<0.05) in silica-induced malignant transformation cells compared with the control group. PERK , P-JNK and Cyclin D1 expression increased (P<0.01, P<0.01, P<0.05) in B(a)P-induced group compared with the control group. PERK and P-JNK expression decreased (P<0.01), while P-p38, Cyclin D1 and CDK4 expression increased (P<0.05, P<0.05, P<0.01) in B(a)P-induced group compared with the silica-induced group. Conclusion: MAPK and cyclin D1/CDK4 activation expressed differently in human embryo lung fibroblasts malignant transformation induced by silica and benzopyrene.

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Silica-based systems for oral delivery of drugs, macromolecules and cells

Cited by 121 publications

References 118 publications

<p>Effects of miR-26a on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by a Mesoporous Silica Nanoparticle - PEI - Peptide System</p>

<p>Effects of miR-26a on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by a Mesoporous Silica Nanoparticle - PEI - Peptide System</p>

Hesperidin: synthesis and characterization of bioflavonoid complex

Activation of MAPK and Cyclin D1/CDK4 in Malignant Transformation of Human Embryonic Lung Fibroblasts Induced by Silica and Benzopyrene

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