Silica-based nanoparticles for photodynamic therapy applications

Couleaud, Pierre; Morosini, Vincent; Frochot, Céline; Richeter, Sébastien; Raehm, Laurence; Durand, Jean‐Olivier

doi:10.1039/c0nr00096e

Cited by 250 publications

(178 citation statements)

References 39 publications

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“…It was found that both PpIX-Ole-DOPC and PpIX-Ole are much more effective than the non-functionalized PpIX and the results were due to the drug delivery characteristic of the liposome, which showed an effective role in endocytosis. In the same study it was also reported (Couleaud et al 2010, Lucky et al 2015, Piao et al 2008.…”

Section: The Role Of Photosensitizer Nanocarriers For Pdt 1107supporting

confidence: 67%

“…Moreover, ORMOSIL can possess functional groups added to the surface that make these SiNPs promising vectors for PDT applications (Couleaud et al 2010). For instance, Ohulchanskyy et al were able to prepare ORMOSIL NPs with a PS molecule covalently incorporated into the SiNP aiming to minimize the PS release during systemic circulation (Ohulchanskyy et al 2007).…”

Section: The Role Of Photosensitizer Nanocarriers For Pdt 1107mentioning

confidence: 99%

See 1 more Smart Citation

An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Mesquita

Dias

Gamelas

et al. 2018

An. Acad. Bras. Ciênc.

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Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.

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Section: The Role Of Photosensitizer Nanocarriers For Pdt 1107supporting

confidence: 67%

Section: The Role Of Photosensitizer Nanocarriers For Pdt 1107mentioning

confidence: 99%

An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Mesquita

Dias

Gamelas

et al. 2018

An. Acad. Bras. Ciênc.

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“…Such drawbacks of molecular photosensitisers for PDT can be overcome through the use of nanoparticles as drug delivery systems. 5 Silica nanoparticles, 6 polymeric nanoparticles, 7 magnetic nanoparticles, 5,7 quantum dots, 8 upconverting nanoparticles 9 and especially gold nanoparticles 5 are emerging as ideal candidates for use as delivery vehicles of hydrophobic photosensitisers for PDT. In the field of gold nanoparticles (AuNPs), Brust and co-workers reported a method based on the use of tetraoctylammonium bromide as the phase transfer reagent for the synthesis of gold nanoparticles functionalised with hydrophobic ligands that were ultimately soluble in polar solvents.…”

Section: Introductionmentioning

confidence: 99%

Water soluble, multifunctional antibody-porphyrin gold nanoparticles for targeted photodynamic therapy

Penon

Marín

Russell

et al. 2017

Journal of Colloid and Interface Science

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Photodynamic therapy (PDT) is a treatment of cancer by which tumour cells are destroyed using reactive oxygen species produced by photosensitisers following activation with visible or near infrared light. Successful PDT depends on the solubility and the targeting ability of the photosensitisers. In this work, the synthesis of a porphyrin-based water soluble nanoparticle conjugate containing a targeting agent that recognises the erbB2 receptor overexpressed on the surface of particular cancer cells is reported. The nanoparticle conjugates were synthesised following two different protocols, viz. a biphasic and a monophasic method, with the aim to determine which method yielded the optimal nanosystem for potential PDT applications. The nanoparticles were characterised using UV-Vis absorption and fluorescence spectroscopies together with transmission electron microscopy and zeta potential measurements; and their ability to produce singlet oxygen following irradiation was investigated following the decay in absorption of a singlet oxygen probe. The nanoparticles synthesised using the monophasic method were shown to produce the highest amount of singlet oxygen and were further functionalised with anti-erbB2 antibody to target the erbB2 receptors expressed on the surface of SK-BR-3 human breast cancer cells. The water soluble, antibody-porphyrin nanoparticle conjugates were shown to elicit targeted PDT of the breast cancer cells.

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“…Photodynamic therapy (PDT) is another important emerging research field for the development of nanoscale therapeutics (Bechet et al, 2008;Couleaud et al, 2010b;Vanderesse et al, 2011) that can optimize drug delivery of materials or systems. Photodynamic therapy involves the use of light, photosensitizers and oxygen.…”

Section: Photodynamic Therapymentioning

confidence: 99%