Silica-associated systemic erythematosus lupus or mineral dust lupus?

Masson, Cécile; Audran, M; Pascaretti, C.; Chevailler, Alain; Subra, Jean‐François; Tuchais, E; Kahn, Marcel-Francis

doi:10.1177/096120339700600101

Cited by 20 publications

(20 citation statements)

References 5 publications

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“…Larger clinic-based case-series, occupational cohort, registry-linkage, and case-control studies have also been conducted, many of them published since 1995 . The diseases that have been examined most often include SSc (24,25,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), RA (26,31-33, 35,37,44-46), SLE (29,33,35,37,[47][48][49][50][51][52], and some of the SVV with renal involvement (53)(54)(55)(56). The population prevalence of these diseases differs by several orders of magnitude; RA is the most common (approximately 1 case per 100) (57,58), compared to SLE (approximately 5 cases per 10,000) (58,59) and to SSc and WG (fewer than 5 cases per 100,000) (58,(60)(61)(62).…”

Section: Silica Dust and Autoimmune Diseasementioning

confidence: 99%

“…This includes three cases of SLE and five SLE/SSc overlap cases in the study of 50 scouring powder factory workers (29) and 28 SLE cases identified in a study of 30,000 male uranium miners examined for silicosis (52). Silica exposure levels were very high in these cohorts.…”

Section: Sderodermamentioning

confidence: 99%

“…Other particulates with adjuvant activity include talc, tin, and iron ore dust with relatively low silica content (85,125). Authors of a recent case-series study suggested renaming silica-dust lupus as mineral-dust lupus (50).…”

Section: Exposure Charaterstis and Confoaundingmentioning

confidence: 99%

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Occupational exposure to crystalline silica and autoimmune disease.

Parks

Conrad

Cooper

1999

Environ Health Perspect

243

102

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Occupational exposure to silica dust has been examined as a possible risk factor with respect to several systemic autoimmune diseases, including scleroderma, rheumatoid arthritis, systemic lupus erythematosus, and some of the small vessel vasculitidies with renal involvement (e.g., Wegener granulomatosis). Crystalline silica, or quartz, is an abundant mineral found in sand, rock, and soil. High-level exposure to respirable silica dust can cause chronic inflammation and fibrosis in the lung and other organs. Studies of specific occupational groups with high-level silica exposure (e.g., miners) have shown increased rates of autoimmune diseases compared to the expected rates in the general population. However, some clinic- and population-based studies have not demonstrated an association between silica exposure and risk of autoimmune diseases. This lack of effect may be due to the limited statistical power of these studies to examine this association or because the lower- or moderate-level exposures that may be more common in the general population were not considered. Experimental studies demonstrate that silica can act as an adjuvant to nonspecifically enhance the immune response. This is one mechanism by which silica might be involved in the development of autoimmune diseases. Given that several different autoimmune diseases may be associated with silica dust exposure, silica dust may act to promote or accelerate disease development, requiring some other factor to break immune tolerance or initiate autoimmunity. The specific manifestation of this effect may depend on underlying differences in genetic susceptibility or other environmental exposures.

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Section: Silica Dust and Autoimmune Diseasementioning

confidence: 99%

Section: Sderodermamentioning

confidence: 99%

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Occupational exposure to crystalline silica and autoimmune disease.

Parks

Conrad

Cooper

1999

Environ Health Perspect

243

102

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“…In this century, many published case reports have described various autoimmune disorders in workers or patients who were occupationally exposed to crystalline silica [Bramwell 1914;Erasmus 1957;Jones et al 1976;Mehlhorn 1984;Mehlhorn et al 1990a;de Bandt et al 1991;Yanez Diaz et al 1992;Pelmear et al 1992;Caux et al 1991;Cointrel et al 1997;Yamamoto et al 1994;Guseva 1991;Ebihara 1982;Agarwal et al 1987;Koeger et al 1991Koeger et al , 1992Koeger et al , 1995Anandan et al 1995;Sanchez-Roman et al 1993;Aoki et al 1988;Fukata et al 1983Fukata et al , 1987Muramatsu et al 1989;Masuda 1981;Tokumaru et al 1990;Perez Perez et al 1986;Bernardini and Iannaccone 1982;Siebels et al 1995;Suratt et al 1977;Meyniel et al 1981;Hatron et al 1982;Masson et al 1997;Özoran et al 1997;Haustein 1998;Cledes et al 1982;Mehlhorn and Gerlach 1990]. The most frequently reported autoimmune diseases were scleroderma, systemic lupus erythematosus (lupus), rheumatoid arthritis, autoimmune hemolytic anemia [...…”

Section: Autoimmune and Chronic Renal Diseasesmentioning

confidence: 99%

Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance for Silicosis — Michigan and New Jersey, 2003–2010

Filios

Mazurek²,

Schleiff³

et al. 2015

MMWR Morb. Mortal. Wkly. Rep.

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“…Free silica has been classified as carcinogen 30) . Though many studies [31][32][33][34] have been carried out on the pulmonary effects of silica exposure, the studies on extra-pulmonary effects of free silica exposure such as progressive systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, glomerulonephritis and vasculitis are lacking.…”

Section: Silica Related Diseases Other Than Silicosismentioning

confidence: 99%

Occupational Health Research in India.

Saiyed¹,

Tiwari²

2004

INDUSTRIAL HEALTH

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India being a developing nation is faced with traditional public health problems like communicable diseases, malnutrition, poor environmental sanitation and inadequate medical care. However, globalization and rapid industrial growth in the last few years has resulted in emergence of occupational health related issues. Agriculture (cultivators i.e. land owners+ agriculture labourers) is the main occupation in India giving employment to about 58% of the people. The major occupational diseases/morbidity of concern in India are silicosis, musculo-skeletal injuries, coal workers' pneumoconiosis, chronic obstructive lung diseases, asbestosis, byssinosis, pesticide poisoning and noise induced hearing loss. There are many agencies like National Institute of Occupational Health, Industrial Toxicology Research Centre, Central Labour Institute, etc. are working on researchable issues like Asbestos and asbestos related diseases, Pesticide poisoning, Silica related diseases other than silicosis and Musculoskeletal disorders. Still much more is to be done for improving the occupational health research. The measures such as creation of advanced research facilities, human resources development, creation of environmental and occupational health cells and development of database and information system should be taken.

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Silica-associated systemic erythematosus lupus or mineral dust lupus?

Cited by 20 publications

References 5 publications

Occupational exposure to crystalline silica and autoimmune disease.

Occupational exposure to crystalline silica and autoimmune disease.

Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance for Silicosis — Michigan and New Jersey, 2003–2010

Occupational Health Research in India.

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