“…Larger clinic-based case-series, occupational cohort, registry-linkage, and case-control studies have also been conducted, many of them published since 1995 . The diseases that have been examined most often include SSc (24,25,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), RA (26,31-33, 35,37,44-46), SLE (29,33,35,37,[47][48][49][50][51][52], and some of the SVV with renal involvement (53)(54)(55)(56). The population prevalence of these diseases differs by several orders of magnitude; RA is the most common (approximately 1 case per 100) (57,58), compared to SLE (approximately 5 cases per 10,000) (58,59) and to SSc and WG (fewer than 5 cases per 100,000) (58,(60)(61)(62).…”