Silencing of miR20a Is Crucial for Ngn1-Mediated Neuroprotection in Injured Spinal Cord

Jee, Min Ki; Jung, Jin Sun; Im, Young Jae; Jung, Sung Jun; Kang, Seok Kwon

doi:10.1089/hum.2011.121

Cited by 57 publications

(49 citation statements)

References 41 publications

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“…This suggests that miR-21 expression in the hippocampus may affect multiple components of TBI pathophysiology. miR20a may cause continuing motor neuron degeneration when overexpressed in spinal cord injury (SCI) (71). Blocking miR20a in SCI animals effectively induces definitive motor neuron survival and neurogenesis, and improves the functional deficit.…”

Section: Traumatic Injurymentioning

confidence: 99%

Neuroprotection of microRNA in neurological disorders (Review)

Wang

Cheng

et al. 2014

Biomedical Reports

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Abstract. MicroRNAs (miRNAs) are small, endogenous, non-coding RNA molecules that function as post-transcriptional regulators of gene expression by imperfect base-pairing with the 3'-untranslated regions of their target mRNAs. Altered expression of numerous miRNAs has been shown to be extensively involved in the pathogenesis of various diseases and cancers. Additionally, the specific expression of miRNAs in the nervous system has indicated that miRNAs are critical for the occurrence and development of neurological diseases. Increasing evidence has shown that specific miRNAs target the expression of particular proteins that are significant in the disease pathogenesis. Therefore, miRNA-mediated regulation may be important in the occurrence and development of neurological diseases and may function as a novel biomarker and tool for clinical therapy. In the present study, the significance of miRNAs is reviewed in a number of neurological disorders and the possibility of their use in therapeutic interventions is evaluated.

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Section: Traumatic Injurymentioning

confidence: 99%

Neuroprotection of microRNA in neurological disorders (Review)

Wang

Cheng

et al. 2014

Biomedical Reports

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“…Several therapeutic approaches have been used to improve the microenvironment of the injured spinal cord and/or to stimulate the endogenous repair in an attempt to ameliorate secondary injury 9, 11, 13, 14. Although a majority of studies has focused on compounds with neuroprotection against secondary injury in SCI, their therapeutic efficacy remains controversial 15.…”

Section: Introductionmentioning

confidence: 99%

microRNAs in Spinal Cord Injury: Potential Roles and Therapeutic Implications

Ning¹,

Gao²,

Liu³

et al. 2014

Int. J. Biol. Sci.

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microRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. miRNAs can modulate gene expression and thus play important roles in diverse neurobiological processes, such as cell differentiation, growth, proliferation and neural activity, as well as the pathogenic processes of spinal cord injury (SCI) like inflammation, oxidation, demyelination and apoptosis. Results from animal studies have revealed the temporal alterations in the expression of a large set of miRNAs following SCI in adult rats, and the expressional changes in miRNAs following SCI is bidirectional (increase or decrease). In addition, several miRNAs have distinct roles in prognosis of SCI (protective, detrimental and varied). Taken together, the existing evidence suggests that abnormal miRNA expression following SCI contributes to the pathogenesis of SCI, and miRNAs may become potential targets for the therapy of SCI.

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“…It is well known that miRNAs could regulate Notch signaling. Moreover, recent studies have also shown that Drosha and miR-20 regulates the expression of neurogenin [21,22], suggesting the regulatory effects of miRNAs on pancreas development.…”

Section: Mirna-regulated Signaling Pathways In Pancreas Developmentmentioning

confidence: 97%

The Role of miRNAs in the Development of Normal Pancreas and Pancreatic Cancer, and Their Roles in Tumor Progression

Kong

Ahmad

et al. 2014

MicroRNA in Development and in the Progression of Cancer

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The microRNAs (miRNAs) have been shown to play important roles in the control of many normal biological processes including cell differentiation and organogenesis. During the development of normal pancreas, several miRNAs including miR-375, miR-7, miR-124, etc. have been shown to regulate exocrine and endocrine cell differentiation. These regulations could in part be mediated through the miRNA-mediated deregulation of transforming growth factor-β, Notch, and Hedgehog signaling, which are the signal transduction pathways that are critically involved in organogenesis during normal development. However, deregulated expression of miRNAs could also lead to the development and progression of pancreatic cancer. Moreover, miRNAs are also known to regulate the development and maintenance of pancreatic cancer stem cells and epithelial-to-mesenchymal transition phenotypic cells, which are typically responsible for drug resistance, tumor recurrence, and metastasis. Therefore, targeting specific miRNAs by oligonucleotide/nanoparticle vector delivery or regulation of miRNAs by natural agents could become novel strategies for the treatment of pancreatic cancer with better treatment outcome in combination with conventional therapeutics.

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Silencing of miR20a Is Crucial for Ngn1-Mediated Neuroprotection in Injured Spinal Cord

Cited by 57 publications

References 41 publications

Neuroprotection of microRNA in neurological disorders (Review)

Neuroprotection of microRNA in neurological disorders (Review)

microRNAs in Spinal Cord Injury: Potential Roles and Therapeutic Implications

The Role of miRNAs in the Development of Normal Pancreas and Pancreatic Cancer, and Their Roles in Tumor Progression

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